Bio

Irogue Igbinosa, MD is a Maternal-Fetal Medicine fellow at Stanford University. She graduated from the University of Houston and earned her medical degree at Baylor College of Medicine. She subsequently completed her residency in Obstetrics and Gynecology Residency at Louisiana State University School of Medicine Baton Rouge. After residency, she was an AAMC-CDC Public Health Policy Fellow able to serve in the CDC Emergency Operations Center and contribute to research for health care providers regarding the management of the Zika virus in pregnant persons. Dr. Igbinosa's current research interests include severe maternal morbidity and mortality, health disparities and equity, anemia in pregnancy, infectious diseases, and clinical trials.

Academic Appointments

All Publications

  • Editorial: How COVID-19 has affected maternal-fetal medicine and obstetrics? Current opinion in obstetrics & gynecology Igbinosa, I., Lyell, D. J. 2021; 33 (5): 416-418

    View details for DOI 10.1097/GCO.0000000000000741

    View details for PubMedID 34459793

  • Inflammatory bowel disease and the impact on rates of chorioamnionitis, sepsis, and severe maternal morbidity Igbinosa, I., Trepman, P., Sie, L., Leonard, S. A., Herrero, T. MOSBY-ELSEVIER. 2021: S441–S442

    View details for Web of Science ID 000621547401249

  • Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease. American journal of obstetrics and gynecology Igbinosa, I., Miller, S., Bianco, K., Nelson, J., Kappagoda, S., Blackburn, B. G., Grant, P., Subramanian, A., Lyell, D., El-Sayed, Y., Aziz, N. 2020

    View details for DOI 10.1016/j.ajog.2020.08.001

    View details for PubMedID 32771381

  • The obstetric research landscape: a cross-sectional analysis of clinical trials from 2007-2020. American journal of obstetrics & gynecology MFM Steinberg, J. R., Weeks, B. T., Reyes, G. A., Conway Fitzgerald, A. n., Zhang, W. Y., Lindsay, S. E., Anderson, J. N., Chan, K. n., Richardson, M. T., Magnani, C. J., Igbinosa, I. n., Girsen, A. n., El-Sayed, Y. Y., Turner, B. E., Lyell, D. J. 2020: 100253

    Abstract

    Obstetric complications impact over a third of women globally, but are underrepresented in clinical research. Little is known about the comprehensive obstetric clinical trial landscape, how it compares to other fields, or factors associated with the successful completion of obstetric trials.To characterize obstetric clinical trials registered on ClinicalTrials.gov with the primary objective of identifying features associated with early discontinuation and results reporting.This is a cross-sectional study with descriptive, logistic regression and cox regression analyses of clinical trials registered on ClinicalTrials.gov. Our primary exposure variables were trial focus (obstetric or non-obstetric) and trial funding (industry, United States government or academic). We conducted additional exploratory analyses of other trial features including design, enrollment, and therapeutic focus. We examined the associations of exposure variables and other trial features with two primary outcomes: early discontinuation and results reporting.We downloaded data for all studies (n=332,417) registered on ClinicalTrials.gov from October 1, 2007 to March 9, 2020 from the Aggregate Analysis of the ClinicalTrials.gov database. We excluded studies with a non-interventional design (n=63,697) and those registered before October 1, 2007 (n=45,209). 4,276 (1.9%) obstetric trials (i.e. interventional studies), and 219,235 (98.1%) non-obstetric trials were compared. Among all trials, 2.8% of academic-funded trials, 1.9% of United States government-funded trials, and 0.4% of industry-funded trials focused on obstetrics. The quantity of obstetric trials increased over time (10.8% annual growth rate). Compared to non-obstetric trials, obstetric trials had a greater risk of early discontinuation (adjusted hazard ratio 1.40, 95% confidence interval: 1.21 to 1.62, p<0.0001) and similar odds of results reporting (adjusted odds ratio 0.89, 95% confidence interval: 0.72 to 1.10, p=0.19). Among obstetric trials funders after controlling for confounding variables, United States government-funded trials were at lowest risk of early discontinuation (US government adjusted hazard ratio 0.23, 95% confidence interval 0.07 to 0.69, p=0.009, industry reference; academic adjusted hazard ratio 1.04, 95% confidence interval 0.62 to 1.74, p=0.88). Academic-funded trials had the lowest odds of results reporting after controlling for confounding variables (academic institutions adjusted odds ratio 0.39, 95% confidence interval 0.22 to 0.68, p=0.0009; industry reference; US government adjusted odds ratio 1.06 95% confidence interval 0.53 to 2.09, p=0.87).Obstetric trials represent only 1.9% of all clinical trials in ClinicalTrials.gov and have comparatively poor completion. All stakeholders should commit to increasing the number of obstetric trials and improving their completion and dissemination to ensure clinical research reflects the obstetric burden of disease and advances maternal health.

    View details for DOI 10.1016/j.ajogmf.2020.100253

    View details for PubMedID 33043288

    View details for PubMedCentralID PMC7537600

  • Relationships of uterine fibroids to racial/ethnic disparities in severe maternal morbidity Igbinosa, I., Leonard, S. A., El-Sayed, Y. Y., Lyell, D. J. MOSBY-ELSEVIER. 2020: S170–S171

    View details for DOI 10.1016/j.ajog.2019.11.263

    View details for Web of Science ID 000504997300247

  • Early discontinuation and results reporting in obstetric clinical trials: An analysis of 3317 clinicaltrials.gov investigations Weeks, B., Steinberg, J. R., Turner, B., Reyes, G., Conway, A. A., Zhang, W. Y., Lindsay, S., Anderson, J. N., Chan, K., Igbinosa, I., Girsen, A., El-Sayed, Y. Y., Lyell, D. J. MOSBY-ELSEVIER. 2020: S55–S56

    View details for DOI 10.1016/j.ajog.2019.11.082

    View details for Web of Science ID 000504997300067

  • The obstetric clinical trial landscape: a characterization of clinicaltrials.gov investigations from 2007-2018 Steinberg, J. R., Weeks, B., Turner, B., Reyes, G., Conway, A. A., Zhang, W. Y., Lindsay, S., Anderson, J. N., Chan, K., Igbinosa, I., Girsen, A., El-Sayed, Y. Y., Lyell, D. J. MOSBY-ELSEVIER. 2020: S459–S460

    View details for DOI 10.1016/j.ajog.2019.11.739

    View details for Web of Science ID 000504997301052

  • Antepartum anemia and racial/ethnic disparities in blood transfusion in california Igbinosa, I., Leonard, S. A., Butwick, A. J., Lyell, D. J. MOSBY-ELSEVIER. 2020: S304

    View details for DOI 10.1016/j.ajog.2019.11.480

    View details for Web of Science ID 000504997300463