Clinical Focus

  • General Surgery

Academic Appointments

Professional Education

  • Medical Education: University of California Davis School of Medicine (1985) CA
  • Internship: Alameda County Medical Center UCSF East Bay Surgical Residency (1986) CA
  • Board Certification: American Board of Surgery, General Surgery (1992)
  • Residency: UC Davis East Bay (1990) CA

All Publications

  • Fatal Case of Perforated Cytomegalovirus Colitis: Case Report and Systematic Review. Surgical infections Fisher, A. T., Bessoff, K. E., Nicholas, V., Badger, J., Knowlton, L., Forrester, J. D. 2021


    Objective: We describe a patient with history of heart transplant on maintenance immunosuppression who presented with sigmoid colon perforation from cytomegalovirus (CMV) colitis and performed a systematic review of outcomes after perforated CMV colitis. Background: Cytomegalovirus enterocolitis is uncommon among solid organ transplant patients and can result in small or large bowel perforation. Methods: We systematically reviewed articles describing patients with CMV enterocolitis with small or large bowel perforations from PubMed, Embase, and Web of Science from database inception to February 2021. Results: Seventy-seven articles were identified containing 84 patients with perforated CMV enterocolitis. The most prevalent comorbid diagnosis was human immunodeficiency virus (HIV; 27 patients, 32%), and 37 patients (44%) were taking corticosteroids at time of presentation. The ileum was the most common location for a perforation (26 patients, 31%). Odds of survival were lower for patients with small bowel perforation (odds ratio [OR], 0.38; 95% confidence interval [CI], 0.14-0.98) and HIV/acquired immunodeficiency syndrome (AIDS; OR, 0.32; 95% CI, 0.11-0.88). Odds of survival were higher for patients with large bowel perforation (OR, 2.64; 95% CI, 1.03-7.09), radiographically diagnosed perforation (OR, 3.45; 95% CI, 1.12-11.60) and those who received a CMV antiviral (OR, 9.19; 95% CI, 3.26-28.48). Conclusions: Perforated CMV enterocolitis is uncommon even in immunocompromised hosts. Clinicians should maintain a high level of suspicion for CMV-induced bowel perforation in this population because antiviral treatment is associated with increased odds of survival.

    View details for DOI 10.1089/sur.2021.173

    View details for PubMedID 34860604