Jayant Menon

All Publications

• Technological innovation and ethical response in neurosurgery. The virtual mentor : VM Menon, J., Riskin, D. J. 2015; 17 (1): 62-68

  View details for DOI 10.1001/virtualmentor.2015.17.01.mhst1-1501

  View details for PubMedID 25594718

• Design and Experimental Evaluation of a Skin-Stretch Haptic Device for Improved Control of Brain-Computer Interfaces Sketch, S. M., Deo, D. R., Menon, J. P., Okamura, A. M., IEEE IEEE COMPUTER SOC. 2015: 272-277

  View details for Web of Science ID 000370974900038

• Intracranial Ablative Procedures for the Treatment of Chronic Pain NEUROSURGERY CLINICS OF NORTH AMERICA Menon, J. P. 2014; 25 (4): 663-?

  Abstract

  Three main techniques delineate a possible role for intracranial ablative procedures in patients with chronic pain. Recent studies demonstrate a continued need for clinical investigation into central mechanisms of neuroablation to best define its role in the care of patients with otherwise intractable and severe pain syndromes. Cingulotomy can result in long-term pain relief. Although it can be associated with subtle impairments of attention, there is little risk to other cognitive domains.

  View details for DOI 10.1016/j.nec.2014.06.003

  View details for Web of Science ID 000343190900004

• Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell Intermediate STEM CELLS Hovinga, K. E., Shimizu, F., Wang, R., Panagiotakos, G., van der Heijden, M., Moayedpardazi, H., Correia, A. S., Soulet, D., Major, T., Menon, J., Tabar, V. 2010; 28 (6): 1019-1029

  Abstract

  Glioblastoma multiforme (GBM) is a highly heterogeneous malignant tumor. Recent data suggests the presence of a hierarchical organization within the GBM cell population that involves cancer cells with stem-like behavior, capable of repopulating the tumor and contributing to its resistance to therapy. Tumor stem cells are thought to reside within a vascular niche that provides structural and functional support. However, most GBM studies involve isolated tumor cells grown under various culture conditions. Here, we use a novel three-dimensional organotypic "explant" system of surgical GBM specimens that preserves cytoarchitecture and tumor stroma along with tumor cells. Notch inhibition in explants results in decreased proliferation and self-renewal of tumor cells but is also associated with a decrease in endothelial cells. When endothelial cells are selectively eliminated from the explants via a toxin conjugate, we also observed a decrease in self-renewal of tumor stem cells. These findings support a critical role for tumor endothelial cells in GBM stem cell maintenance, mediated at least in part by Notch signaling. The explant system further highlighted differences in the response to radiation between explants and isolated tumor neurospheres. Combination treatment with Notch blockade and radiation resulted in a substantial decrease in proliferation and in self-renewal in tumor explants while radiation alone was less effective. This data suggests that the Notch pathway plays a critical role in linking angiogenesis and cancer stem cell self-renewal and is thus a potential therapeutic target. Three-dimensional explant systems provide a novel approach for the study of tumor and microenvironment interactions.

  View details for DOI 10.1002/stem.429

  View details for Web of Science ID 000279103500003

  View details for PubMedID 20506127