Contact

  • Academic
    jiwenli@stanford.edu
    University - Scholar Department: School of Medicine Position: Medical Fellow

All Publications

  • CARDIODIAGNOSTIC FINDINGS IN PATIENTS WITH CHEST PAIN IN A LONGITUDINAL POST-ACUTE COVID SYNDROME CLINIC Li, J., Quach, T., Tiwari, A., Cui, J., Linda, G., Saigal, K., Yang, P. C. ELSEVIER SCIENCE INC. 2024: 660

    View details for Web of Science ID 001291434300661

  • CARDIODIAGNOSTIC FINDINGS IN PATIENTS WITH CHEST PAIN IN A LONGITUDINAL POST-ACUTE COVID SYNDROME CLINIC Li, J., Quach, T., Tiwari, A., Cui, J., Linda, G., Saigal, K., Yang, P. C. ELSEVIER SCIENCE INC. 2024: 660

    View details for Web of Science ID 001324901500661

  • Guideline-directed medical therapy improves cell viability in an iPSC-derived cardiomyocyte hypoxia injury model Li, J., Ikeda, G., Tzng, E., Inoue, H., Ieki, M., Yang, P. 2024

    View details for DOI 10.1161/circ.150.suppl_1.4147229

  • Surface Protein Profiling of Extracellular Vesicles: A Novel Biomarker Approach to detect heart allograft acute rejection Ikeda, G., Ieki, M., Inoue, H., Tzng, E., Li, J., Sierra, R., Wakatsuki, S., Valentine, H., Yang, P. 2024

    View details for DOI 10.1161/circ.150.suppl_1.4146973

  • Dorsal Root Ganglion Nerve Block Causing Reverse Takotsubo Cardiomyopathy Li, J., Tuzovic, M., Cheng, E. LIPPINCOTT WILLIAMS & WILKINS. 2023

    View details for DOI 10.1161/circ.148.suppl_1.18058

    View details for Web of Science ID 001157891308183

  • EDUCATING PATIENTS AT DISCHARGE: PERCEIVED RESPONSIBILITIES AMONG NURSES AND RESIDENTS AT AN ACADEMIC MEDICAL CENTER Yang, A., Shan, R., Launer, H., Li, J., Zektser, Y. A., Emmanouilidou, E., Krishnan, D., Dermenchyan, A., Simon, W., Czypinski, L. SPRINGER. 2023: S335-S336

    View details for Web of Science ID 001043057201137

  • Optimizing Guideline Directed Medical Therapy in Recently Hospitalized Patients With Heart Failure in a Large Urban Veterans Affairs Medical Center Moolchandani, P., Patel, S., Saito, A., Gregorio, S., Li, J. LIPPINCOTT WILLIAMS & WILKINS. 2022

    View details for Web of Science ID 000890856908186

  • An acetate switch regulates stress erythropoiesis. Nature medicine Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., Moon, Y. A., Gerard, R. D., Huang, C. L., Comerford, S. A., Hammer, R. E., Horton, J. D., Chen, R., Garcia, J. A. 2014; 20 (9): 1018-26

    Abstract

    The hormone erythropoietin (EPO), which is synthesized in the kidney or liver of adult mammals, controls erythrocyte production and is regulated by the stress-responsive transcription factor hypoxia-inducible factor-2 (HIF-2). We previously reported that the lysine acetyltransferase CREB-binding protein (CBP) is required for HIF-2α acetylation and efficient HIF-2-dependent EPO induction during hypoxia. We now show that these processes require acetate-dependent acetyl CoA synthetase 2 (ACSS2). In human Hep3B hepatoma cells and in EPO-generating organs of hypoxic or acutely anemic mice, acetate levels rise and ACSS2 is required for HIF-2α acetylation, CBP-HIF-2α complex formation, CBP-HIF-2α recruitment to the EPO enhancer and efficient induction of EPO gene expression. In acutely anemic mice, acetate supplementation augments stress erythropoiesis in an ACSS2-dependent manner. Moreover, in acquired and inherited chronic anemia mouse models, acetate supplementation increases EPO expression and the resting hematocrit. Thus, a mammalian stress-responsive acetate switch controls HIF-2 signaling and EPO induction during pathophysiological states marked by tissue hypoxia.

    View details for DOI 10.1038/nm.3587

    View details for PubMedID 25108527

    View details for PubMedCentralID PMC4159437

  • The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. The Journal of biological chemistry Chen, R., Xu, M., Hogg, R. T., Li, J., Little, B., Gerard, R. D., Garcia, J. A. 2012; 287 (36): 30800-11

    Abstract

    Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors. HIF-1α plays a prominent role in hypoxic gene induction. HIF-2α target genes are more restricted but include erythropoietin (Epo), one of the most highly hypoxia-inducible genes in mammals. We previously reported that HIF-2α is acetylated during hypoxia but is rapidly deacetylated by the stress-responsive deacetylase Sirtuin 1. We now demonstrate that the lysine acetyltransferases cAMP-response element-binding protein-binding protein (CBP) and p300 are required for efficient Epo induction during hypoxia. However, despite close structural similarity, the roles of CBP and p300 differ in HIF signaling. CBP acetylates HIF-2α, is a major coactivator for HIF-2-mediated Epo induction, and is required for Sirt1 augmentation of HIF-2 signaling during hypoxia in Hep3B cells. In comparison, p300 is a major contributor for HIF-1 signaling as indicated by induction of Pgk1. Whereas CBP can bind with HIF-2α independent of the HIF-2α C-terminal activation domain via enzyme/substrate interactions, p300 only complexes with HIF-2α through the C-terminal activation domain. Maximal CBP/HIF-2 signaling requires intact CBP acetyltransferase activity in both Hep3B cells as well as in mice.

    View details for DOI 10.1074/jbc.M111.244780

    View details for PubMedID 22807441

    View details for PubMedCentralID PMC3436323