Trends in sex differences in neurodevelopmental outcomes among extremely preterm infants.
Archives of disease in childhood. Fetal and neonatal edition
Boghossian, N. S., Mack, N., Bell, E. F., Tan, S., Stoll, B., Rysavy, M., Ambalavanan, N., Tyson, J. E., Das, A., Hintz, S. R., Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Jobe, A. H., Caplan, M. S., Polin, R. A., Oh, W., Keszler, M., Laptook, A. R., Vohr, B. R., Hensman, A. M., Burke, R. T., Stephens, B. E., Yatchmink, Y., Alksninis, B., Basso, K., Vieira, E., Keszler, L., Knoll, A., Leach, T. M., Leonard, M. R., Noel, L., Pierre, L. S., Vogt, R. A., Watson, V. E., Hibbs, A. M., Fanaroff, A. A., Wilson-Costello, D. E., Newman, N. S., Siner, B. S., Williams, A., Roth, E., Truog, W., Kilbride, H., Parimi, P., Gauldin, C., Scott, A., Johnson, K., Gaetano, L., Merhar, S. L., Poindexter, B. B., Schibler, K., Russell, D., Donovan, E. F., Bridges, K., Steichen, J. J., Yolton, K., Alexander, B., Fischer, E. E., Grisby, C., Mersmann, M. W., Mincey, H. L., Hessling, J., Gratton, T. L., Jackson, L. D., Kirker, K., Muthig, G., Stacey, S., Hayes, D., Thompson, J., Beiersdorfer, T., Goldberg, R. N., Michael Cotten, C., Goldstein, R. F., Auten, K. J., Finkle, J., Fisher, K. A., Foy, K. A., Grimes, S., Gustafson, K. E., Lohmeyer, M. B., Laughon, M. M., Bose, C. L., Bernhardt, J., Bose, G., Clark, C. L., Patel, R. M., Carlton, D. P., Adams-Chapman, I., Hale, E. C., Loggins, Y. C., Bottcher, D. I., LaRossa, M. M., Carter, S. L., Sewell, L., Sanders, A., Smikle, G., Mackie, C., Laursen, J., Bremer, A. A., Higgins, R. D., Wright, L. L., McClure, E. M., Archer, S. W., Sokol, G. M., Poindexter, B. B., Lemons, J. A., Dusick, A. M., Papile, L., Harmon, H., Lytle, C., Bohnke, L. G., Eaken, G., Herron, D. E., Hines, A., Miller, L. C., Minnich, H. M., Richard, L., Wilson, L. D., Watkins, D., Gunn, S., Joyce, J., Khan, A. M., Kennedy, K. A., Jones, P. M., Evans, P. W., Akpa, E. G., Alaniz, N. I., Allain, E., Arldt-McAlister, J., Boricha, F., Brandt, P., Burson, K., Guajardo, M. C., Dempsey, A., Dieterich, S. E., Harris, B. F., Franco, C. I., Garcia, C., Green, C., Hall, D., Jiminez, M., John, J., Lis, A. E., Major-Kincade, T., Martin, K., Martin, S. C., Mason, C. M., McDavid, G. E., McKee, S. L., Morris, B. H., Orekoya, P. A., Boral, D. S., Pierce Tate, P. L., Poundstone Lillie, M. L., Reddoch, S., Reddy, T., Rodgers, S., Siddiki, S. K., Simmons, M. C., Sperry, D., Stephens, E., Whitely, L. L., Wright, S. L., Sanchez, P. J., Nelin, L. D., Jadcherla, S. R., Luzader, P., Fortney, C. A., Besner, G. E., Parikh, N. A., Kenneth Poole, W., Wallace, D., Newman, J. E., Auman, J. O., Crawford, M. M., Hastings, B. K., McClure, E. M., Petrie Huitema, C. M., Zaterka-Baxter, K. M., Meurs, K. P., Chock, V. Y., Stevenson, D. K., Bethany Ball, M., Adams, M. M., Ahlfors, C. E., Baran, J. M., Bentley, B., Bond, L. E., Brudos, G. K., Davis, A. S., DeAnda, M. E., DeBattista, A. M., Fleisher, B. E., Huffman, L. C., Kohn, J. G., Krueger, C., Lee-Ancajas, J. C., Palmquist, A. W., Proud, M. S., Pyle, R. P., Sivakumar, D., Stebbins, R. D., John, N. H., Weiss, H. E., Frantz, I. D., McGowan, E. C., MacKinnon, B. L., Nylen, E., Furey, A., Brussa, A., Sibley, C., Peralta-Carcelen, M., Nelson, K. G., Bailey, K. J., Biasini, F. J., Chopko, S. A., Collins, M. V., Cosby, S. S., Moses, M. B., Phillips, V. A., Preskitt, J., Rector, R. V., Whitley, S., Devaskar, U., Garg, M., Purdy, I. B., Chanlaw, T., Geller, R., Finer, N. N., Rasmussen, M. R., Vaucher, Y. E., Wozniak, P. R., Arnell, K., Bridge, R., Demetrio, C., Fuller, M. G., Rich, W., Colaizy, T. T., Widness, J. A., Harmon, H. M., Brumbaugh, J. E., Acarregui, M. J., Johnson, K. J., Eastman, D. L., Walker, J. R., Goecke, C. A., Schmelzel, M. L., Baack, M. L., Hogden, L. A., Henning, M. M., Elenkiwich, C., Broadbent, M., Muyden, S. V., Ellsbury, D. L., Bass, D. B., Tud, T. L., Duara, S., Bauer, C. R., Everett-Thomas, R., Worth, A. M., Allison, M., Diaz, A. N., Mathews, E. 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A., Butler, C., Jacobs, H., Cervone, P., Close, N., Getter, P., Gilliam, W., Greisman, S., Konstantino, M., Poulsen, J., Romano, E., Taft, J., Williams, J.
2024
Abstract
OBJECTIVE: To examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18-26 months' corrected age from 1999 to 2018 differed between male and female infants.DESIGN: This retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females. Interactions between sex and time were assessed to evaluate temporal differences in the outcome by sex. Variables adjusted for included centre, maternal age, ethnicity/race, gestational age and small for gestational age.PATIENTS: Inborn infants with gestational age of 22-26 weeks at NICHD Neonatal Research Network hospitals from 1999 to 2018.MAIN OUTCOME MEASURE: Change over time in survival without moderate or severe NDI at 18-26 months' corrected age between male and female infants.RESULTS: Of 26 307 infants, 13 045 (49.6%) were male. Survival without moderate or severe NDI declined for both sexes over time, from 32.9% to 30.6% for males and from 47.4% to 40.0% for females, between 1999-2003 and 2014-2018. Males were less likely than females to survive without moderate or severe NDI (aRR=0.80; 95% CI 0.78 to 0.83). Changes in survival without moderate or severe NDI did not differ between males and females.CONCLUSION: There were no differential changes in survival without moderate or severe NDI between male and female infants.
View details for DOI 10.1136/archdischild-2024-327239
View details for PubMedID 39288987
Length of prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants: effects on neonatal adaptation and psychomotor development
PSYCHOPHARMACOLOGY
Casper, R. C., Gilles, A. A., Fleisher, B. E., Baran, J., Enns, G., Lazzeroni, L. C.
2011; 217 (2): 211-219
Abstract
This study evaluated the question whether length of in utero exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants might affect neonatal outcome and psychomotor development in infancy.Birth outcome was determined in the offspring of 55 women with major depressive disorder who used SSRI medication for different durations during their pregnancies. At an average age of 14 months, children underwent a pediatric examination and an evaluation with the Bayley Scales of Infant Development (BSID-II).Duration of in utero exposure to SSRIs was negatively associated with total Apgar scores, specifically the activity subscale. Odds ratios for a low score (<2) on this scale were 3.8 and 6.0 at 1 and 5 min, respectively. Newborns with longer exposure were more often admitted to the Neonatal Intensive Care Unit (p < .03). Mental Development Index scores of the infants were not associated with the length of gestational exposure to SSRIs. A longer duration of exposure increased the risk for lower Psychomotor Developmental Index and Behavioral Rating Scale scores in infancy (p = 0.012 and p = 0.007, respectively) on the BSID-II.The findings provide evidence that the length of prenatal SSRI antidepressant use can affect neonatal adjustment and can have an effect on psychomotor test scores in infancy. Importantly, the children's mental development and motor function by neurological examination were within the normal range. Timing of exposure to SSRIs during susceptible periods of fetal development and variations in the severity of maternal depression may have contributed to the associations.
View details for DOI 10.1007/s00213-011-2270-z
View details for PubMedID 21499702
