Clinical Focus

  • Anatomic and Clinical Pathology

Academic Appointments

  • Clinical Instructor, Pathology

Professional Education

  • Fellowship: Stanford University Pathology Fellowships (2025) CA
  • Fellowship: Stanford University Pathology Fellowships (2024) CA
  • Board Certification: American Osteopathic Board of Pathology, Anatomic and Clinical Pathology (2023)
  • Residency: Rush University Medical Center (2023) IL
  • Medical Education: AT Still University Kirksville College of Osteopathic Medicine (2018) MO

Contact

  • Clinical (Primary)  Pathology 300 Pasteur Dr Rm L235 MC 5324 Palo Alto, CA 94304 (650) 725-6902 (fax)

Additional Clinical Info

Additional Info

  • Mail Code: 5324

All Publications

  • Hormone Receptor and HER2 Testing in Breast Cancer: Latest Questions Answered. Surgical pathology clinics Solarewicz, J., Allison, K. H. 2025; 18 (4): 735-750

    Abstract

    Evolving data continue to require pathologists to adjust breast cancer biomarker interpretation and reporting. ER low positive and HER2 low/ultralow are not distinct subtypes of breast cancer but have important treatment implications. ER low positive (1%-10%) cancers resemble ER-negative tumors but may still benefit from endocrine therapy. HER2 low and ultralow, as defined in DESTINY-Breast 04/06 trials, guide eligibility for trastuzumab-deruxtecan in metastatic cases. Accurate distinction between HER2 IHC 0/no staining versus 0+/some staining, is therefore, now necessary despite concerns about its reproducibility and predictive power.

    View details for DOI 10.1016/j.path.2025.07.004

    View details for PubMedID 41224416

  • Buried Deep. Journal of hospital medicine Ruge, M., Surati, M., Manesh, R., Segreti, J., Solarewicz, J., Mba, B. 2021; 16 (12): 757-762

    View details for DOI 10.12788/jhm.3584

    View details for PubMedID 34338628

  • Subdeltoid Rice Bodies in a Patient with Rheumatoid Arthritis on Disease Modifying Antirheumatic Drug Therapy: A Case Report. JBJS case connector Fice, M., Patel, V., Solarewicz, J., Gusho, C., Miller, I., Blank, A. 2021; 11 (2)

    Abstract

    A 58-year-old man with rheumatoid arthritis (RA) on disease modifying antirheumatic drug therapy presented with chronic right shoulder pain. Magnetic resonance imaging was concerning for rice body disease which was confirmed through histology after intraoperative deltoid bursa resection.Rice bodies can develop regardless of RA symptom severity or the degree of RA medical therapy administered. Therefore, physicians should not disregard rice bodies as a possible cause of symptoms in individuals on appropriate RA medical therapy or who are demonstrating adequate RA symptom and flair control.

    View details for DOI 10.2106/JBJS.CC.20.00879

    View details for PubMedID 34115659

  • Progressive Dyspnea and Pleural Effusion-When the Answer Lies Buried in the History. The American journal of medicine Bell, E., Schwartz, M., Abrams, R. I., Solarewicz, J., Khandelwal, S. 2021; 134 (1): 57-59

    View details for DOI 10.1016/j.amjmed.2020.04.040

    View details for PubMedID 32511956

  • Adiponectin secretion from cardiomyocytes produces canonical multimers and partial co-localization with calsequestrin in junctional SR. Molecular and cellular biochemistry Solarewicz, J., Manly, A., Kokoszka, S., Sleiman, N., Leff, T., Cala, S. 2019; 457 (1-2): 201-214

    Abstract

    Adiponectin (ADN) is an abundant protein in serum, secreted by adipocytes, that acts as a signal for fat metabolism. It is marked by a complex molecular structure that results from processes within the secretory pathway, producing a canonical set of multimers. ADN may also be secreted from cardiomyocytes, where a unique sarcomeric endoplasmic/sarcoplasmic reticulum (ER/SR) substructure has been characterized primarily for its Ca handling. We expressed ADN in cultured primary adult cardiomyocytes and nonmuscle (COS) cells. After 48 h of ADN expression by adenovirus treatment, roughly half of synthesized ADN was secreted from cardiomyocytes, and half was still in-transit within inner membrane compartments, similar to COS cells. Cardiomyocytes and COS cells both produced ADN in the three canonical forms: trimers, hexamers, and 18-mers. Higher rates of secretion occurred for higher-molecular weight multimers, especially 18-mers. The highest levels of ADN protein, whether in transit or secreted, were present as trimers and hexamers. In nonmuscle cell lines, ADN trafficked through ER and Golgi compartments as expected. In contrast, ADN in primary adult cardiomyocytes populated ER/SR tubules along the edges of sarcomeres that emanated from nuclear surfaces. Prominent co-localization of ADN occurred with calsequestrin, a marker of junctional SR, the Ca2+-release compartment of the cell. The early steps in ADN trafficking re-trace those recently described for newly made junctional SR proteins, involving a nuclear envelope (NE) translocation into SR tubules that are oriented along sarcolemmal transverse (T)-tubules (NEST pathway).

    View details for DOI 10.1007/s11010-019-03524-9

    View details for PubMedID 30919218