Judah Kupferman

All Publications

• Markers of Prognosis for Acute Esophageal Necrosis: A Systematic Review. Digestive diseases (Basel, Switzerland) Kupferman, J., Matin, M., Wend, M., Rubio Castillon, J. J., Mitchell, R., Aron, J., Ye, R. 2025: 1-11

  Abstract

  Acute esophageal necrosis (AEN) is a rare and lethal condition that may progress to sepsis and perforations. Most related literature comes from case reports; however, a few small reviews have been published. We conducted a large systematic review of AEN using PubMed, Medline, and Embase to organize data into one consolidated manuscript, find potential prognosticators of illness, and determine possible treatment guidelines for AEN.Advanced searches were performed of all English case reports from 1990 to 2021 using medical subject heading terms. Data on patient age, sex, comorbidities, initial presentation, management, progression of illness, and hospital survival were collected.Our study included 226 articles, encompassing 319 cases. A total of 32.3% of patients had diabetes, 26.6% had hypertension, and 19.7% had alcohol use disorder. Overall, 66.5% presented with an upper gastrointestinal bleed and 21.9% developed sepsis or esophageal perforation. In total, 60.9% of patients were reported to have survived their illness, but 16.6% of cases did not have their discharge status documented. Interestingly, patients presenting with pain or ketoacidosis demonstrated improved survival.AEN becomes more prevalent as patients age and develop cardiovascular disease, which increases the risk of developing a hypoperfusive state and mucosal injury to the distal esophagus. Early fluid resuscitation, acid-reducing agents, and bowel rest may serve as potential lifesaving interventions, and antibiotics should be considered if there is concern for infection. Patients require close follow-up in anticipation of impending stricture.

  View details for DOI 10.1159/000543815

  View details for PubMedID 39864415

• Light at the end of the tunnel: bridging the gap from the duodenum to the jejunum. VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy Kupferman, J., Mitchell, R., Gurram, K., Kolli, S., Aron, J. 2024; 9 (2): 88-91

  Abstract

  Video 1Video describing the case, procedure, and outcomes.

  View details for DOI 10.1016/j.vgie.2023.09.017

  View details for PubMedID 38357030

• Nailed it: endoscopic retrieval of an abnormally shaped nail from a toddler's esophagus. VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy Gurram, K., Kupferman, J., Lourdusamy, V., Aron, J. 2023; 8 (11): 432-434

  Abstract

  Video 1.

  View details for DOI 10.1016/j.vgie.2023.07.002

  View details for PubMedID 38026710

• Straight from the Big Apple: endoscopic retrieval of a whole apple from the sigmoid colon. VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy Kupferman, J., Walfish, A., Aron, J., Gurram, K. 2023; 8 (10): 426-428

  Abstract

  Video 1Endoscopic retrieval of a whole apple from the sigmoid colon.

  View details for DOI 10.1016/j.vgie.2023.06.012

  View details for PubMedID 37849778

• Get It Out: Hydrogel Capsules Impacting in the Esophagus ACG CASE REPORTS JOURNAL Kupferman, J., Wend, M., Lourdusamy, V., Walfish, A., Aron, J., Gurram, K. 2023; 10 (7): e01094

  View details for DOI 10.14309/crj.0000000000001094

  View details for Web of Science ID 001026174200001

  View details for PubMedID 37441620

  View details for PubMedCentralID PMC10335817

• Efficacy of remote dielectric sensing (ReDS) in the prevention of heart failure rehospitalizations: a meta-analysis JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES Sattar, Y., Zghouzi, M., Suleiman, A. M., Sheikh, A., Kupferman, J., Sarfraz, A., Arshad, J., Mir, T., Ullah, W., Pacha, H., Thakkar, S., Elgendy, I. Y., Alraies, M. 2021; 11 (5): 646-652

  Abstract

  The clinical efficacy of remote dielectric sensing (ReDS) monitoring is not well known. Digital databases were searched to identify relevant articles. Pooled unadjusted odds ratio (OR) for dichotomous outcomes were calculated using a random-effects model. Findings were reported as a point estimate with its 95% confidence interval (CI). A total of 985 patients across seven studies were included in the meta-analysis. Patients with heart failure monitored with ReDS had significantly lower odds of hospital readmission compared with non-ReDS patients (OR = 0.40; 95% CI 0.29-0.56; z = 5.43 p = 0.000, I2 = 0%). Subgroup analysis based on the duration of follow-up showed a lower odd of readmission within 30 days (OR = 0.36; 95% CI 0.18-0.71; z = 2.93; p = 0.003; I2 5.7%), as well as between 1 and 3 months (OR = 0.42; 95% CI 0.29-0.61; z = 4.54; p = 0.000; I2 = 0.0%). ReDS effect of lower readmissions of HF was observed irrespective of the duration of follow-up (<1-month vs 1-3 months). ReDS monitoring significantly lowers the odds of HF readmission within 3 months compared to participants not using ReDS.

  View details for DOI 10.1080/20009666.2021.1955451

  View details for Web of Science ID 000698305500015

  View details for PubMedID 34567456

  View details for PubMedCentralID PMC8462919

• Chilaiditi syndrome: A structural displacement in a heart failure patient ANNALS OF MEDICINE AND SURGERY Song, D., Seen, T., Almas, T., Ireifej, B., Kupferman, J., Khedro, T., Alshamlan, A., Abdulhadi, A., Sattar, Y., Alraies, M. 2021; 68: 102687

  Abstract

  Chilaiditi's sign is often found incidentally on chest or abdominal radiograph and can be accompanied by clinical symptoms such as abdominal pain, gastrointestinal complications, and less commonly associated with dyspnea.In this interesting case, we discover lingering dyspnea in our 79 year old male with a past medical history of asthma and heart failure with preserved ejection fraction admitted for acute heart failure exacerbation with reduced ejection fraction along with a new incidental finding of Chilaiditi's sign on chest radiograph. Patient received optimal diuretics and guideline-directed medical treatment for heart failure exacerbation, but mild dyspnea with pleuritic chest pain persisted. Dyspnea with pleurisy was likely attributed to a structural anatomical defect (Chilaiditi's sign) that can be picked up on imaging.Chilaiditi syndrome can be an incidental cause of ongoing persistent dyspnea, and if symptoms are severe, intervention can be warranted for symptomatic resolution.Chilaiditi syndrome should be considered as a possible diagnosis among patients with a history of heart failure and incidental Chilaiditi's sign on chest radiographic imaging who suffer from persistent dyspnea and pleurisy despite optimal diuretics and guideline-directed medical treatment.

  View details for DOI 10.1016/j.amsu.2021.102687

  View details for Web of Science ID 000685274500010

  View details for PubMedID 34401144

  View details for PubMedCentralID PMC8353377