Bio

Dr. Tirumalasetty is a board-certified, fellowship-trained allergist and immunologist in the Stanford Health Care Allergy, Asthma, and Immunodeficiency Clinic. She is also a clinical assistant professor in the Department of Medicine, Division of Pulmonary, Allergy & Critical Care Medicine at Stanford University School of Medicine. Dr. Tirumalasetty completed fellowship training in allergy and immunology from the Northwestern University Feinberg School of Medicine in Chicago, IL.

She specializes in diagnosing and treating asthma and food and drug allergies in adults. Her clinical focus areas also include chronic cough, immunotherapy to prevent allergies, and biologics to treat asthma. Biologics are used to prevent airway inflammation and other asthma symptoms. Dr. Tirumalasetty works closely with her patients to provide a comprehensive evaluation and an innovative, patient-centered care plan.

Dr. Tirumalasetty has been co-investigator in multiple clinical trials funded by the National Institutes of Health (NIH). Her research interests include studying health inequity in food allergy, sustainability in medicine, and severe allergic asthma. Dr. Tirumalasetty is the primary investigator on a research project supported by Stanford Medicine’s Spectrum Pilot Grant. She is collaborating with a multidisciplinary team of physicians within Stanford. The Green Inhaler Pilot Project focuses on educating Stanford Health Care providers and encouraging them to prescribe inhalers that emit lower levels of greenhouse gases.

Dr. Tirumalasetty has presented to her colleagues at lectures all over the nation. Her presentations have covered a range of topics, including atopy in asthma, managing food and drug allergies, and anaphylaxis (severe allergic reaction). Dr. Tirumalasetty has been interviewed as an allergy expert for several articles in national publications, including The New York Times. She serves as a medical advisor on the board of directors for Securing Safe Food, a nonprofit organization that works with food pantries to provide allergen-free food to people with food allergies.

Dr. Tirumalasetty’s articles have appeared in numerous peer-reviewed journals, including The Journal of Allergy and Clinical Immunology, Journal of Asthma, Expert Review of Clinical Immunology, and Annual Review of Immunology. She published a book chapter about immunotherapy for food allergies in Reference Module in Food Science. She has served as an ad hoc peer reviewer for Clinical and Translational Allergy, Allergy Journal, and World Allergy Organization Journal.

Dr. Tirumalasetty is a fellow of the American Academy of Allergy, Asthma & Immunology and the American College of Allergy, Asthma & Immunology. She is a member of several professional organizations, including the European Academy of Allergy & Clinical Immunology; World Allergy Organization; Western Society of Allergy, Asthma & Immunology; American Thoracic Society; and California Society of Allergy, Asthma and Immunology.

Clinical Focus

  • Allergy and Immunology

Academic Appointments

Professional Education

  • Board Certification: American Board of Allergy and Immunology, Allergy and Immunology (2006)
  • Fellowship: Northwestern University Allergy and Immunology Fellowship (2006) IL
  • Residency: Northwestern University Internal Medicine Residency (2004) IL
  • Medical Education: Drexel University School of Medicine (2001) PA

Contact

  • Academic
    jtsetty@stanford.edu
    University - Academic staff Department: Medicine - Med/Pulmonary and Critical Care Medicine Position: Clinical Assistant Professor
  • Clinical (Primary)  Atherton Allergy, Asthma, and Immunodeficiency Clinic 3351 El Camino Real Ste 201 Atherton, CA 94027 (650) 503-0169 (fax)

Additional Clinical Info

Additional Info

All Publications

  • The Immunobiology and Treatment of Food Allergy. Annual review of immunology Barshow, S., Tirumalasetty, J., Sampath, V., Zhou, X., Seastedt, H., Schuetz, J., Nadeau, K. 2024

    Abstract

    IgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium leading to the aberrant production of alarmins and activation of TH2-type allergic inflammation. The treatment of IgE-FA has historically been avoidance with acute management of allergic reactions, but advances in allergen-specific immunotherapy and the development of biologics and other novel therapeutics are rapidly changing the landscape of food allergy treatment. Here, we discuss the pathogenesis and immunobiology of IgE-FA in addition to its diagnosis, prognosis, and treatment. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

    View details for DOI 10.1146/annurev-immunol-090122-043501

    View details for PubMedID 38360544

  • Peanut allergy: risk factors, immune mechanisms, and best practices for oral immunotherapy success. Expert review of clinical immunology Tirumalasetty, J., Barshow, S., Kost, L., Morales, L., Sharma, R., Lazarte, C., Nadeau, K. C. 2023: 1-11

    Abstract

    Peanut oral immunotherapy (pOIT) is the only FDA-approved treatment for food allergy and its adoption amongst allergist immunologists and their patients is growing. pOIT is the subject of numerous clinical trials, however, the focus is often on treatment efficacy, safety, and tolerability, rather than identifying patients most likely to benefit from pOIT. Here, we review existing data on the clinical and immunological outcomes of pOIT that inform best practices for pOIT candidate selection.In this review, we describe the natural history of peanut allergy, summarize immunological and clinical outcomes of pOIT at different ages, discuss the optimization of pOIT in key age groups, and finally suggest an ideal age range at which to initiate pOIT for best outcomes.pOIT is currently underutilized by patients and allergist-immunologists. Developing guidelines for selecting appropriate patients and optimizing treatment may help to increase access to pOIT. Many aspects of pOIT need additional study to further our understanding of the optimal timing to start pOIT, with careful consideration to clinical, immunological, and quality of life outcomes.

    View details for DOI 10.1080/1744666X.2023.2209318

    View details for PubMedID 37129440

  • The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders. The Journal of allergy and clinical immunology Sindher, S. B., Barshow, S., Tirumalasetty, J., Arasi, S., Atkins, D., Bauer, M., Bégin, P., Collins, M. H., Deschildre, A., Doyle, A. D., Fiocchi, A., Furuta, G. T., Garcia-Lloret, M., Mennini, M., Rothenberg, M. E., Spergel, J. M., Wang, J., Wood, R. A., Wright, B. L., Zuberbier, T., Chin, A. R., Long, A., Nadeau, K. C., Chinthrajah, R. S. 2023; 151 (3): 595-606

    Abstract

    Continuing insight into the molecular mechanisms of atopic disorders has enabled the development of biologics to precisely target these diseases. Food allergy (FA) and eosinophilic gastrointestinal disorders (EGIDs) are driven by similar inflammatory molecular mechanisms and exist along the same atopic disease spectrum. Therefore, many of the same biologics are being investigated to target key drivers of mechanisms shared across the disease states. The enormous potential of biologics for the treatment of FA and EGIDs is highlighted by the significant increases in the number of ongoing clinical trials (more than 30) evaluating their use in these disease states, as well as by the recent US Food and Drug Administration approval of dupilumab for the treatment of eosinophilic esophagitis. Here we discuss past and current research into the use of biologics in FA and EGIDs and their potential role in improving treatment options in the future, with the need to have biologics widely clinically available.

    View details for DOI 10.1016/j.jaci.2023.01.007

    View details for PubMedID 36872039

  • The Effects of Long-term Food Oral Immunotherapy on Compliance, Quality of Life, and Perceived Burden of Care Tirumalasetty, J., Sullivan, L., Martinez, K., Collins, W., Albarran, M., Gajare, P., Kost, L., Chinthrajah, S., Sindher, S., Cao, S. MOSBY-ELSEVIER. 2023: AB29

    View details for Web of Science ID 000991651900084

  • Asthma, surgery, and general anesthesia: a review. The Journal of asthma : official journal of the Association for the Care of Asthma Tirumalasetty, J., Grammer, L. C. 2006; 43 (4): 251-4

    Abstract

    Over 20 million Americans are affected with asthma. Many will require some type of surgical procedure during which their asthma management should be optimized. Preoperative assessment of asthma should include a specialized history and physical as well as pulmonary function testing. In many asthmatic patients, treatment with systemic corticosteroids and bronchodilators is indicated to prevent the inflammation and bronchoconstriction associated with endotracheal intubation. The use of corticosteroids has not been shown to adversely affect wound healing or increase the rate of infections postoperatively. Preoperative systemic corticosteroids may be used safely in the majority of patients to decrease asthma-related morbidity.

    View details for DOI 10.1080/02770900600643162

    View details for PubMedID 16809236

  • Monitoring Clinical Response to Immunomodulatory Treatments Reference Module in Food Science J, T., R, M., , R, R., L, K., K, F., J, R., I, B., AR, C., RS, C., S, S. 2023

    View details for DOI 10.3389/fonc.2013.00109

  • Beware Of The Glilded Lung Nodule Belvitch, P., Tirumalasetty, J. AMER THORACIC SOC. 2014

    View details for Web of Science ID 000209838206224

  • The TLR7 ligand loxoribine induces pentraxin 3 expression in peripheral blood mononuclear calls Tirumalasetty, J. I., Shin, S. C., Miranowski, A. C., Truong-Tran, Q. A., Grammer, L. C., Greenberger, P. A., Schleimer, R. P. MOSBY, INC. 2006: S13

    View details for DOI 10.1016/j.jaci.2005.12.056

    View details for Web of Science ID 000235865300053

  • Enhanced expression of innate immune genes in chronic rhinosinusitis Truong-Tran, A. Q., Kern, R., Conley, D., Retsema, S., Grammer, L., Suh, L., Tirumalasetty, J., Tancowny, B., Tripathi, A., Schleimer, R. MOSBY, INC. 2006: S183

    View details for DOI 10.1016/j.jaci.2005.12.728

    View details for Web of Science ID 000235865301208

https://orcid.org/0000-0002-0171-5046