Larissa Kiwakyou

All Publications

• Heartfelt Healing: Charting New Trajectories in Postsurgical Pain. Anesthesia and analgesia Vanneman, M. W., Kiwakyou, L. M., Harrison, T. K., Mariano, E. R. 2024; 138 (6): 1187-1191

  View details for DOI 10.1213/ANE.0000000000006871

  View details for PubMedID 38771601

• The Year in Graduate Medical Education: Selected Highlights from 2023. Journal of cardiothoracic and vascular anesthesia Patel, S. J., Notarianni, A. P., Martin, A. K., Tsai, A., Pulton, D. A., Linganna, R. E., Bhatte, S., Montealegre-Gallegos, M., Patel, B., Waldron, N. H., Nimma, S. R., Kothari, P., Kiwakyou, L., Baskin, S. M., Feinman, J. W. 2024

  Abstract

  This special article is the third in an annual series of the Journal of Cardiothoracic and Vascular Anesthesia that highlights significant literature from the world of graduate medical education published over the past year. Major themes addressed in this review include the potential uses and pitfalls of artificial intelligence in graduate medical education, trainee well-being and the rise of unionized house staff, the effect of gender and race/ethnicity on residency application and attrition rates, and the adoption of novel technologies in medical simulation and education. The authors thank the editorial board for again allowing us to draw attention to some of the more interesting work published in the field of graduate medical education during 2023. We hope that the readers find these highlights thought-provoking and informative as we all strive to successfully educate the next generation of anesthesiologists.

  View details for DOI 10.1053/j.jvca.2024.05.003

  View details for PubMedID 39261208

• Beating Heart Transplants-Overview and Implications for Anesthesiologists. Journal of cardiothoracic and vascular anesthesia Kothari, P., Kiwakyou, L. M., Guenthart, B. A., Vanneman, M. 2023

  Abstract

  As the demand for heart allografts for transplantation continues to rise, ex vivo organ perfusion strategies are playing an increasingly important role in the preservation of organs from donation after circulatory death and extended-criteria donors. One such method uses the Organ Care System (TransMedics, Andover, MA). Traditionally, this technique of preservation requires 2 periods of warm ischemia and subsequent cardioplegic arrest. In a novel surgical technique pioneered at the authors' institution, heart allograft implantation no longer requires a second cardioplegic arrest. This article discusses the surgical approach for this procedure, the advantages and disadvantages of this approach, and analogs to current clinical practice to theorize what impact this may have on cardiac transplantation volumes in the future.

  View details for DOI 10.1053/j.jvca.2023.12.031

  View details for PubMedID 38228423

• Highlights and Perioperative Implications from the 2022 American College of Cardiology and American Heart Association Guidelines for Diagnosis and Management of Aortic Disease. Journal of cardiothoracic and vascular anesthesia Kothari, P., Bodmer, N. J., Ellis, S., Kiwakyou, L. M., Choi, C. 2023

  Abstract

  As the understanding of aortic diseases and their complications grow, increasing importance of uniformity in diagnosis and management is crucial for optimal care of this patient population. The 2022 American College of Cardiology and American Heart Association Guidelines for Diagnosis and Management of Aortic Disease discusses these considerations in detail. The purpose of this review is to highlight essential recommendations that are of relevance to the perioperative physician who manages these patients. A few notable points include, shared decision-making with patients, creation of multidisciplinary aortic teams, lower diameter thresholds for surgery in certain situations, and increased testing for patients with heritable aortic diseases. In addition to briefly reviewing basics of aortic diseases, the authors discuss changes to guidelines that are especially relevant to perioperative care.

  View details for DOI 10.1053/j.jvca.2023.05.037

  View details for PubMedID 37353422

• Buprenorphine and Cardiac Surgery: Navigating the Challenges of Pain Management. Journal of cardiothoracic and vascular anesthesia Fernando, R. J., Graulein, D., Hamzi, R. I., Augoustides, J. G., Khalil, S., Sanders, J., Sibai, N., Hong, T. S., Kiwakyou, L. M., Brodt, J. L. 2022

  View details for DOI 10.1053/j.jvca.2022.04.050

  View details for PubMedID 35667956

• What's in a Word? Qualitative and Quantitative Analysis of Leadership Language in Anesthesiology Resident Feedback Journal of Graduate Medical Education Arking, N., Lai, C., Kiwakyou, L. M., Lochbaum, G. M., Shafer, A., Howard, S. K., Mariano, E. R., Fassiotto, M. 2019; 11 (1): 44-52

  View details for DOI 10.4300/JGME-D-18-00377.1

• X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy. Chemical communications (Cambridge, England) Starkewolf, Z. B., Miyachi, L., Wong, J., Guo, T. 2013; 49 (25): 2545-7

  Abstract

  Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.

  View details for DOI 10.1039/c3cc38100e

  View details for PubMedID 23423224