All Publications

  • Current clinical opinion on CFTR dysfunction and patient risk of pancreatitis: diagnostic and therapeutic considerations. Expert review of gastroenterology & hepatology Phadke, M. Y., Sellers, Z. M. 2022

    Abstract

    Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride and bicarbonate secretion is integral to the pancreas' ability to produce the alkaline pancreatic juice required for proper activation of enzymes for digestion. Disruption in this process increases the risk for pancreatitis.Using original basic and clinical research, as well as clinical case reports and recent reviews indexed in PubMed, we discuss why patients with CFTR dysfunction are at risk for pancreatitis. We also discuss diagnostic modalities for assessing CFTR function, as well as new therapeutic advancements and the impact these are having on pancreatic function, pancreatitis in particular.CFTR-related pancreatitis occurs in the presence of monallelic or biallelic mutations and/or from toxin-mediated channel disruption. Research-based CFTR diagnostics have been expanded, yet all current methods rely on measuring CFTR chloride transport in non-pancreatic cells/tissue. Newer CFTR-directed therapies ("CFTR modulators") are both improving pancreatitis (pancreatic-sufficient CF patients) and increasing the risk for pancreatitis (previously pancreatic-insufficient CF patients). Our experiences with these drugs are enlightening us on how CFTR modulation can affect pancreatitis risk across a wide spectrum of pancreatic disease, and represents an opportunity for therapeutic relief from pancreatitis in those without CF, but who suffer from CFTR-related pancreatitis.

    View details for DOI 10.1080/17474124.2022.2084072

    View details for PubMedID 35623009

  • Neuromyelitis optica spectrum disorder manifested by persistent hiccups and severe esophagitis in an adolescent patient 10.1097/PG9.0000000000000117 Singh , P., Garcia , R., Phadke , M. Y. 2021; 4 (2)

    View details for DOI 10.1097/PG9.0000000000000117

  • Zinc: Roles in pancreatic physiology and disease. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Wang, M., Phadke, M., Packard, D., Yadav, D., Gorelick, F. 2020; 20 (7): 1413-1420

    Abstract

    Zinc is an essential trace element. Deficiencies are frequently seen with gastrointestinal diseases, including chronic pancreatitis, nutritional deficiency, and reduced intestinal absorption. Additionally, reduced zinc levels have been linked to cellular changes associated with acute pancreatitis such as enhanced inflammation with increased macrophage activation and production of inflammatory cytokines such as IL-1β, impaired autophagy, and modulation of calcium homeostasis. Preliminary data suggest that zinc deficiency may lead to pancreatic injury in animal models. The purpose of this review is to explore the biologic effects of zinc deficiency that could impact pancreatic disease. MESH KEYWORDS: Malnutrition, inflammation, trace element.

    View details for DOI 10.1016/j.pan.2020.08.016

    View details for PubMedID 32917512

    View details for PubMedCentralID PMC7572834

  • Faailure to thrive in infants and children. Scientific American Gastroenterology, Hepatolgogy and Endoscopy. Phadke , M. Y., Porto, A. F. Decker Intellcetual Properties . 2017

    View details for DOI 10.2310/7900.5609

  • Obesity and gastrointestinal disorders in children Obesity: A Practical Guide Phatak, U. P., Phadke , M. Y., Pashankar, D. S. Springer International Publishing. 2015 : 149–157