Bio


I have obtained a Ph.D. in Mechanical and Aerospace Engineering from Oklahoma State University, complemented by a Master's degree in the same field. My educational background includes a Bachelor's degree in Mechanical Engineering from Osmania University. With a passion for innovation and a drive to improve healthcare, I have focused my research efforts on the cardiovascular, urology, and respiratory fields. Collaborating with cross-functional teams comprising surgeons, clinicians, engineers, and microbiologists, I have been actively involved in the development of cutting-edge medical devices and technologies. Through my work, I aim to contribute to advancements in these fields and make a positive impact on patient care.

Current Role at Stanford


Research Engineer

Education & Certifications


  • Ph.D., Oklahoma State University, Mechanical and Aerospace Engineering (2021)
  • M.S., Oklahoma State University, Mechanical and Aerospace Engineering (2016)
  • B.E., Osmania University, Mechanical Engineering (2014)

All Publications


  • Valvular complex and tissue remodelling in ovine functional tricuspid regurgitation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Iwasieczko, A., Gaddam, M., Gaweda, B., Goodyke, A., Mathur, M., Lin, C., Zagorski, J., Solarewicz, M., Cohle, S., Rausch, M., Timek, T. A. 2023; 63 (5)

    Abstract

    OBJECTIVES: Pathophysiology of function tricuspid regurgitation (FTR) is incompletely understood. We set out to comprehensively evaluate geometric and tissue remodelling of the tricuspid valve complex in ovine FTR.METHODS: Twenty adult sheep underwent left thoracotomy and pulmonary artery banding (PAB) to induce right heart pressure overload and FTR. After 8 weeks, 17 surviving animals and 10 healthy controls (CTL) underwent sternotomy, echocardiography and implantation of sonomicrometry crystals on right ventricle and tricuspid valvular apparatus. Haemodynamic and sonomicrometry data were acquired in all animals after weaning from cardiopulmonary bypass. Leaflet tissue was harvested for pentachrome histologic analysis and biomechanical testing.RESULTS: Animal weight was 62 ± 5 and 63 ± 3 kg for CTL and PAB, respectively (P = 0.6). At terminal procedure, systolic pulmonary artery pressure was 22 ± 3 and 40 ± 7 mmHg for CTL and PAB, respectively (P = 0.0001). The mean TR grade (+0-4) was 0.8 ± 0.4 and 3.2 ± 1.2 (P = 0.0001) for control and banded animals, respectively. Right ventricle volume (126 ± 13 vs 172 ± 34 ml, P = 0.0019), tricuspid annular area (651 ± 109 vs 865 ± 247 mm2, P = 0.037) and area between papillary muscle tips (162 ± 51 vs 302 ± 75 mm2, P = 0.001) increased substantially while systolic excursion of anterior leaflet decreased significantly (23.8 ± 6.1° vs 7.4 ± 4.5°, P = 0.001) with banding. Total leaflet surface area increased from 806 ± 94 to 953 ± 148 mm2 (P = 0.009), and leaflets became thicker and stiffer.CONCLUSIONS: Detailed analysis of the tricuspid valve complex revealed significant ventricular, annular, subvalvular and leaflet remodelling to be associated with ovine functional tricuspid regurgitation. Durable surgical repair of severe FTR may require a multi-level approach to the valvular apparatus.

    View details for DOI 10.1093/ejcts/ezad115

    View details for PubMedID 36951551

  • Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation. Journal of visualized experiments : JoVE Gaweda, B., Iwasieczko, A., Gaddam, M., Bush, J. D., MacDougal, B., Timek, T. A. 2023

    Abstract

    The pathophysiology of severe functional tricuspid regurgitation (FTR) associated with right ventricular dysfunction is poorly understood, leading to suboptimal clinical results. We set out to establish a chronic ovine model of FTR and right heart failure to investigate the mechanisms of FTR. Twenty adult male sheep (6-12 months old, 62 ± 7 kg) underwent a left thoracotomy and baseline echocardiography. A pulmonary artery band (PAB) was placed and cinched around the main pulmonary artery (PA) to at least double the systolic pulmonary artery pressure (SPAP), inducing right ventricular (RV) pressure overload and signs of RV dilatation. PAB acutely increased the SPAP from 21 ± 2 mmHg to 62 ± 2 mmHg. The animals were followed for 8 weeks, symptoms of heart failure were treated with diuretics, and surveillance echocardiography was used to assess for pleural and abdominal fluid collection. Three animals died during the follow-up period due to stroke, hemorrhage, and acute heart failure. After 2 months, a median sternotomy and epicardial echocardiography were performed. Of the surviving 17 animals, 3 developed mild tricuspid regurgitation, 3 developed moderate tricuspid regurgitation, and 11 developed severe tricuspid regurgitation. Eight weeks of pulmonary artery banding resulted in a stable chronic ovine model of right ventricular dysfunction and significant FTR. This large animal platform can be used to further investigate the structural and molecular basis of RV failure and functional tricuspid regurgitation.

    View details for DOI 10.3791/64529

    View details for PubMedID 37010284

  • The Presence of a Substrate Strengthens The Jet Generated by Upside-Down Jellyfish FRONTIERS IN MARINE SCIENCE Battista, N., Gaddam, M. G., Hamlet, C. L., Hoover, A. P., Miller, L. A., Santhanakrishnan, A. 2022; 9