Bio

Mariya Mardamshina, MD, PhD, is a postdoctoral fellow in the Department of Bioengineering, working in Prof. Emma Lundberg's lab. She earned her medical degree from Semey State Medical University and completed her PhD at Tel Aviv University, where her research focused on spatial inter- and intratumoral heterogeneity in breast cancer using mass spectrometry-based proteomics. Currently, her work in the Lundberg lab centers on deciphering cell-to-cell proteomic variability within a spatial framework. Her research involves developing integrated pipelines that combine automated multiplexed staining, high-resolution microscopy, artificial intelligence, and ultra-high sensitivity mass spectrometry to achieve comprehensive proteomic analyses.

Stanford Advisors

Contact

  • Academic
    mmariya@stanford.edu
    University - Scholar Department: Bioengineering Position: Postdoctoral Scholar

Additional Info

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All Publications

  • High-parametric protein maps reveal the spatial organization in early-developing human lung. Nature communications Sariyar, S., Sountoulidis, A., Hansen, J. N., Marco Salas, S., Mardamshina, M., Martinez Casals, A., Ballllosera Navarro, F., Andrusivova, Z., Li, X., Czarnewski, P., Lundeberg, J., Linnarsson, S., Nilsson, M., Sundström, E., Samakovlis, C., Lundberg, E., Ayoglu, B. 2024; 15 (1): 9381

    Abstract

    The respiratory system, including the lungs, is essential for terrestrial life. While recent research has advanced our understanding of lung development, much still relies on animal models and transcriptome analyses. In this study conducted within the Human Developmental Cell Atlas (HDCA) initiative, we describe the protein-level spatiotemporal organization of the lung during the first trimester of human gestation. Using high-parametric tissue imaging with a 30-plex antibody panel, we analyzed human lung samples from 6 to 13 post-conception weeks, generating data from over 2 million cells across five developmental timepoints. We present a resource detailing spatially resolved cell type composition of the developing human lung, including proliferative states, immune cell patterns, spatial arrangement traits, and their temporal evolution. This represents an extensive single-cell resolved protein-level examination of the developing human lung and provides a valuable resource for further research into the developmental roots of human respiratory health and disease.

    View details for DOI 10.1038/s41467-024-53752-x

    View details for PubMedID 39477961

    View details for PubMedCentralID PMC11525936

https://orcid.org/0000-0003-0066-0861