Max K. Clary

All Publications

• An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk. Cell reports. Medicine Lancaster, S., Mataraso, S., Reiss, J. D., Contrepois, K., Trowbridge, C. A., Michael, B., Simms, I., Ellenberger, M., Gibson, M., Clary, M., McGuire, L., Wong, F., Canfield, E., Cotter, D., Wang, T., Yang, Y., Nair, R., Krishnan, P., Rangan, P. V., Bianco, Y. K., Bernstein, J. A., Stevenson, D. K., Cowan, T., Rangan, E., Aghaeepour, N., Kasowski, M., Sylvester, K. G., Snyder, M. P. 2026: 102548

  Abstract

  Metabolites present in the mother traverse the placenta to supply energy, essential nutrients, and communication signals to the fetus. To gain a deeper understanding of fetal metabolism and the impacts of maternal metabolic health and medications on the fetus, we have created CordDB. Using mass spectrometry, we systematically document the metabolites and medications that enter and leave the fetus during birth, as well as the associated health records of the mother and newborn. These data reveal the metabolites consumed by the fetus, microbial metabolites (e.g., 3-indolepropionic acid), metabolites obtained from diet, and medications, as well as create a healthy newborn signature. Our study demonstrates that the mother's microbial interactions and nutrition, premature birth, and the mother's use of drugs such as bupivacaine and betamethasone are linked to variations in the metabolic profiles and health of newborns.

  View details for DOI 10.1016/j.xcrm.2025.102548

  View details for PubMedID 41592564

• Remote Versus In-Person Pre-Service Neonatal Resuscitation Training: A Noninferiority Randomized Controlled Trial in Ethiopia. Resuscitation Mediratta, R. P., Clary, M. K., Liang, J. W., Daniels, K., Muhe, L. M., Lee, H. C., Eshetu, B., Berhane, M. 2025: 110556

  Abstract

  In-person neonatal resuscitation training in resource-limited settings faces barriers of geographic access, facilitator and participant availability, and high costs. Remote training could overcome these challenges while maintaining effectiveness. We hypothesized that remote neonatal resuscitation training was noninferior to in-person training for acquiring and retaining knowledge and skills for pre-service education in Ethiopia.We conducted a randomized, controlled, noninferiority trial comparing remote versus in-person neonatal resuscitation training in Jimma, Ethiopia. Medical students without prior resuscitation training were randomized (1:1) to Zoom or in-person delivery of the Helping Babies Breathe curriculum supplemented with videos. Outcome assessors were unmasked, but investigators not involved in participant recruitment remained masked. The primary outcome was neonatal resuscitation skills assessed by the Objective Structured Clinical Examination B (OSCE B) two months after training. The noninferiority margin was 13%. Group differences were assessed by intention-to-treat analysis using one-sided t-tests. A p-value < 0.05 suggests noninferiority. The trial was registered at Clinicaltrials.gov, NCT05854745, and is complete.Between May 1-June 4, 2023, 354 medical students were randomized to remote or in-person training (177 per group). 262 attended the training and completed assessments (remote n=123, in-person n=139; 51% male overall). Two months after training, 199 participants completed assessments (remote n=94, in-person n=105). Mean OSCE B scores were 19.8 (SD 3.24) in the remote group and 20.5 (SD 2.24) in the in-person group (difference -0.76 [95% CI -1.53 to 0.01]; p<0.001 for noninferiority), with similar passing rates (remote 62.8%, in-person 60.0%). No adverse events occurred.Remote training achieved noninferiority to in-person training in resuscitation skill retention at two months among medical students with minimal resuscitation experience, suggesting an effective and promising approach to expanding essential clinical training access globally in resource-limited settings.

  View details for DOI 10.1016/j.resuscitation.2025.110556

  View details for PubMedID 39986344