May Chien
Clinical Assistant Professor, Pediatrics - Hematology & Oncology
Clinical Assistant Professor, Medicine - Hematology
Clinical Focus
- Hematology
- Pediatric Hematology-Oncology
Academic Appointments
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Clinical Assistant Professor, Pediatrics - Hematology & Oncology
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Clinical Assistant Professor, Medicine - Hematology
Professional Education
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Board Certification: American Board of Pediatrics, Pediatric Hematology-Oncology (2021)
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Medical Education: University of Southern California Keck School of Medicine (2010) CA
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Fellowship: Stanford University Pediatric Hematology Oncology Fellowship (2020) CA
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Fellowship: Stanford University Hematology and Oncology Fellowship (2020) CA
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Board Certification: American Board of Internal Medicine, Hematology (2019)
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Board Certification: American Board of Pediatrics, Pediatrics (2014)
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Board Certification: American Board of Internal Medicine, Internal Medicine (2014)
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Residency: LACplusUSC Internal Medicine and Pediatric Residency (2014) CA
2022-23 Courses
- Science of Medicine III-B
INDE 223B (Win) -
Prior Year Courses
2021-22 Courses
- Science of Medicine III-B
INDE 223B (Win)
- Science of Medicine III-B
All Publications
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Lentiviral-mediated Gene Therapy for Adults and Children with Severe Pyruvate Kinase Deficiency: Results from an Ongoing Global Phase 1 Study
AMER SOC HEMATOLOGY. 2022: 4902-4903
View details for DOI 10.1182/blood-2022-170948
View details for Web of Science ID 000893223204404
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The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry.
Blood advances
2022
Abstract
Alpha thalassemia major (ATM) is a hemoglobinopathy that usually results in perinatal demise if in utero transfusions (IUTs) are not performed. We established an international registry (NCT04872179) to evaluate the impact of IUTs on survival to discharge (primary outcome) as well as perinatal and neurodevelopmental secondary outcomes. Forty-nine patients were diagnosed prenatally and 11 were diagnosed postnatally: all 11 spontaneous survivors' genotypes had preserved embryonic zeta globin. We compared three groups of patients; Group 1 were prenatally diagnosed and alive at hospital discharge (n=14), Group 2 were prenatally diagnosed and deceased perinatally (n=5), Group 3 were postnatally diagnosed and alive at hospital discharge (n=11). Group 1 had better outcomes than Groups 2 and 3 in resolution of hydrops, delivery closer to term, shorter hospitalizations, and more frequent average or greater neurodevelopmental outcomes. Earlier IUT initiation correlated with higher neurodevelopmental (Vineland-3) scores (r= -0.72, P=0.02). Preterm delivery after IUT was seen in 3/16 (19%) of patients who continued their pregnancy. When we combined our data with those from two published series, patients who received ≥2 IUTs had better outcomes than those with 0-1 IUT, including resolution of hydrops, delivery ≥34 weeks' gestation, and 5-minute Apgar scores ≥7. Neurodevelopmental assessments were normal in 17/18 of the ≥2 IUT versus 5/13 of the 0-1 IUT group (OR 2.74; P=0.01). Thus, fetal transfusions enable survival of patients with ATM with normal neurodevelopment even in patients presenting with hydrops. Non-directive prenatal counseling of expectant parents should include the option of IUTs.
View details for DOI 10.1182/bloodadvances.2022007823
View details for PubMedID 36306387
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Longitudinal study of 2 patients with cyclic thrombocytopenia, STAT3, and MPL mutations.
Blood advances
2022
Abstract
Cyclic thrombocytopenia (CTP) is a rare disease of periodic platelet count oscillations. The pathogenesis of CTP remains elusive. To study the underlying pathophysiology and genetic and cellular associations with CTP, we applied systems biology approaches to two patients with stable platelet cycling and reciprocal thrombopoietin (TPO) cycling at multiple time points through 2 cycles. Blood transcriptome analysis revealed cycling of platelet-specific genes, which are in parallel with and precede platelet count oscillation, indicating that cyclical platelet production leads platelet count cycling in both patients. Additionally, neutrophil and erythrocyte-specific genes also showed fluctuations correlating with platelet count changes, consistent with TPO effects on hematopoietic progenitors. Moreover, we found novel genetic associations with CTP. One patient had a novel germline heterozygous loss-of-function (LOF) thrombopoietin receptor (MPL) c.1210G>A mutation, and both had pathogenic somatic gain-of-function (GOF) variants in signal transducer and activator of transcription 3 (STAT3). In addition, both patients had clonal T-cell populations that remained stable throughout platelet count cycles. These mutations and clonal T cells may potentially involve in the pathogenic baseline in these patients rendering exaggerated persistent thrombopoiesis oscillations of their intrinsic rhythm upon homeostatic perturbations. This work provides new insights into the pathophysiology of CTP and possible therapies.
View details for DOI 10.1182/bloodadvances.2021006701
View details for PubMedID 35381066
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Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature.
Pediatric blood & cancer
1800: e29499
Abstract
Therapy-related myeloid neoplasms (t-MN) are a distinct subgroup of myeloid malignancies with a poor prognosis that include cases of therapy-related myelodysplastic syndrome (t-MDS), therapy-related myeloproliferative neoplasms (t-MPN) and therapy-related acute myeloid leukemia (t-AML). Here, we report a series of patients with clinical features consistent with juvenile myelomonocytic leukemia (JMML), an overlap syndrome of MDS and myeloproliferative neoplasms that developed after treatment for another malignancy.
View details for DOI 10.1002/pbc.29499
View details for PubMedID 34939322
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Pediatric acquired factor VIII deficiency presenting as hemarthrosis.
Pediatric blood & cancer
1800: e29530
View details for DOI 10.1002/pbc.29530
View details for PubMedID 34913591
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Lentiviral Mediated Gene Therapy for Pyruvate Kinase Deficiency: Interim Results of a Global Phase 1 Study for Adult and Pediatric Patients
AMER SOC HEMATOLOGY. 2021
View details for DOI 10.1182/blood-2021-148161
View details for Web of Science ID 000736398802104
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Lentiviral Mediated Gene Therapy for Pyruvate Kinase Deficiency: Updated Results of a Global Phase 1 Study for Adult and Pediatric Patients
CELL PRESS. 2021: 42-43
View details for Web of Science ID 000645188700083
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A challenging case of recurrent idiopathic hemophagocytic lymphohistiocytosis (HLH) initially presenting in an infant with Pneumocystis jirovecii pneumonia
SPRINGER/PLENUM PUBLISHERS. 2021: S55
View details for Web of Science ID 000639851600094
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A Blueprint for Identifying Phenotypes and Drug Targets in Complex Disorders with Empirical Dynamics.
Patterns (New York, N.Y.)
2020; 1 (9): 100138
Abstract
A central challenge in medicine is translating from observational understanding to mechanistic understanding, where some observations are recognized as causes for the others. This can lead not only to new treatments and understanding, but also to recognition of novel phenotypes. Here, we apply a collection of mathematical techniques (empirical dynamics), which infer mechanistic networks in a model-free manner from longitudinal data, to hematopoiesis. Our study consists of three subjects with markers for cyclic thrombocytopenia, in which multiple cells and proteins undergo abnormal oscillations. One subject has atypical markers and may represent a rare phenotype. Our analyses support this contention, and also lend new evidence to a theory for the cause of this disorder. Simulations of an intervention yield encouraging results, even when applied to patient data outside our three subjects. These successes suggest that this blueprint has broader applicability in understanding and treating complex disorders.
View details for DOI 10.1016/j.patter.2020.100138
View details for PubMedID 33336196
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Lentiviral Mediated Gene Therapy for Pyruvate Kinase Deficiency: A Global Phase 1 Study for Adult and Pediatric Patients
AMER SOC HEMATOLOGY. 2020
View details for DOI 10.1182/blood-2020-137246
View details for Web of Science ID 000607547204296
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Impact of in utero transfusions in fetuses with hydrops fetalis due to alpha thalassemia
MOSBY-ELSEVIER. 2020: S300–S301
View details for DOI 10.1016/j.ajog.2019.11.474
View details for Web of Science ID 000504997300457
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CLINICAL OUTCOME OF HB KHARTOUM/beta THALASSEMIA COMPOUND HETEROZYGOSITY: A GLIMPSE INTO HOMOZYGOUS HB KHARTOUM
WILEY. 2018
View details for Web of Science ID 000428851200076
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ANTICOAGULATION FOR TREATMENT OF PAIN IN VENOUS MALFORMATIONS
WILEY. 2018
View details for Web of Science ID 000428851200243