Megan Gilbert
Clinical Assistant Professor, Pediatrics - Hematology & Oncology
Clinical Focus
- Pediatric Hematology-Oncology
Professional Education
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Board Certification: American Board of Pediatrics, Pediatric Hematology-Oncology (2023)
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Fellowship: Baylor College of Medicine (2021) TX
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Board Certification: American Board of Pediatrics, Pediatrics (2017)
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Residency: Stanford School of Medicine (2017) CA
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Medical Education: University of Texas Southwestern Medical Center (2014) TX
All Publications
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Prophylactic penicillin after 5 years of age in patients with sickle cell disease: A survey of sickle cell disease experts
PEDIATRIC BLOOD & CANCER
2013; 60 (6): 935-939
Abstract
Since the publication of the Prophlyactic Penicillin Study II in 1995, the management of penicillin prophylaxis for children with sickle cell disease (SCD) after 5 years of age has been controversial. In this study, we sought to describe current practice patterns of pediatric hematologists related to cessation of penicillin prophylaxis for children with SCD after 5 years of age.We performed a cross-sectional, electronic survey of pediatric hematologists with expertise in SCD to examine practices regarding penicillin prophylaxis in children with SCD after 5 years of age. We also investigated factors potentially associated with continuation of penicillin prophylaxis using the Jonckheere-Terpstra test and Fisher's exact test.Of the 106 physicians surveyed from 76 centers, 84% completed the survey. Among respondents, 76% routinely recommended cessation of penicillin prophylaxis after 5 years of age. The practice of routinely continuing penicillin after 5 years of age was associated with decreased concern about antibiotic resistance in Streptococcus pneumoniae (P = 0.01), with the usage of prophylactic penicillin in mild SCD genotypes (sickle hemoglobin-C disease and sickle β(+) thalassemia, P = <0.001), and with increasing use of other preventive evaluations (e.g., MRI for silent stroke) in childhood (P = 0.05).Most pediatric hematologists with an SCD expertise recommend cessation of prophylactic penicillin after 5 years of age.
View details for DOI 10.1002/pbc.24395
View details for Web of Science ID 000317934800017
View details for PubMedID 23193095
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PROPHYLACTIC PENICILLIN FOR CHILDREN WITH SICKLE CELL ANEMIA OVER 5 YEARS OF AGE: A NATIONAL SURVEY
WILEY-BLACKWELL. 2012: 1073–73
View details for Web of Science ID 000302864200204
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DOES CONTINUATION OF PROPHYLACTIC PENICILLIN BEYOND AGE 5 PREVENT INVASIVE PNEUOMOCOCCAL DISEASE IN CHILDREN WITH SICKLE CELL ANEMIA?
WILEY-BLACKWELL. 2012: 1015–15
View details for Web of Science ID 000302864200007