Contact

  • Academic
    gaomz@stanford.edu
    University - Student Department: Rad/Radiological Sciences Laboratory Position: Graduate
    University - Student Department: Computer Science Position: Graduate

Additional Info

  • Mail Code: 5488

All Publications

  • Spherical echo-planar time-resolved imaging (sEPTI) for rapid 3D quantitative T 2 * and susceptibility imaging. Magnetic resonance in medicine Wang, N., Liao, C., Cao, X., Nishimura, M., Brackenier, Y. W., Yurt, M., Gao, M., Abraham, D., Alkan, C., Iyer, S. S., Zhou, Z., Jeong, H., Kerr, A., Haldar, J. P., Setsompop, K. 2024

    Abstract

    To develop a 3D spherical EPTI (sEPTI) acquisition and a comprehensive reconstruction pipeline for rapid high-quality whole-brain submillimeter T 2 * $$ {\mathrm{T}}_2^{\ast } $$ and QSM quantification.For the sEPTI acquisition, spherical k-space coverage is utilized with variable echo-spacing and maximum kx ramp-sampling to improve efficiency and signal incoherency compared to existing EPTI approaches. For reconstruction, an iterative rank-shrinking B0 estimation and odd-even high-order phase correction algorithms were incorporated into the reconstruction to better mitigate artifacts from field imperfections. A physics-informed unrolled network was utilized to boost the SNR, where 1-mm and 0.75-mm isotropic whole-brain imaging were performed in 45 and 90 s at 3 T, respectively. These protocols were validated through simulations, phantom, and in vivo experiments. Ten healthy subjects were recruited to provide sufficient data for the unrolled network. The entire pipeline was validated on additional five healthy subjects where different EPTI sampling approaches were compared. Two additional pediatric patients with epilepsy were recruited to demonstrate the generalizability of the unrolled reconstruction.sEPTI achieved 1.4 × $$ \times $$ faster imaging with improved image quality and quantitative map precision compared to existing EPTI approaches. The B0 update and the phase correction provide improved reconstruction performance with lower artifacts. The unrolled network boosted the SNR, achieving high-quality T 2 * $$ {\mathrm{T}}_2^{\ast } $$ and QSM quantification with single average data. High-quality reconstruction was also obtained in the pediatric patients using this network.sEPTI achieved whole-brain distortion-free multi-echo imaging and T 2 * $$ {\mathrm{T}}_2^{\ast } $$ and QSM quantification at 0.75 mm in 90 s which has the potential to be useful for wide clinical applications.

    View details for DOI 10.1002/mrm.30255

    View details for PubMedID 39250435