All Publications


  • Association of inflammatory skin diseases with venous thromboembolism in US adults ARCHIVES OF DERMATOLOGICAL RESEARCH Shaheen, M. S., Silverberg, J. I. 2020

    Abstract

    Patients with certain inflammatory skin diseases have multiple risk factors for venous thromboembolism (VTE). The objective of the study was to determine whether atopic dermatitis (AD), psoriasis, pemphigus, pemphigoid and/or hidradenitis is associated with VTE in US adults. Data were analyzed from the 2002-2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (Nā€‰=ā€‰72,512,581 adults, including 1,389,292 with VTE). In multivariable logistic regression models including age, sex, insurance, household income and race/ethnicity, hospitalization for AD (adjusted odds ratio [95% confidence intervals] 1.22 [1.17-1.27]), pemphigus (1.96 [1.68-2.28]) and pemphigoid (1.64 [1.47-1.83]) was associated with VTE. These associations remained significant in virtually all patient subsets, including males and females, different age groups and those with and without long-term corticosteroid use. In particular, AD, pemphigus and pemphigoid were each associated with DVT and PE. VTE was associated with increased inpatient length of stay, cost of care and mortality across all the inflammatory skin diseases. HS and psoriasis were not consistently associated with VTE. AD, pemphigus and pemphigoid and some subsets of patients with HS were associated with higher odds of hospitalization for VTE. Patients with these inflammatory skin diseases may benefit from increased screening and prevention of VTE.

    View details for DOI 10.1007/s00403-020-02099-6

    View details for Web of Science ID 000546500700001

    View details for PubMedID 32642810

  • Association of asthma with osteopenia, osteoporosis, osteomalacia, and fractures ALLERGY AND ASTHMA PROCEEDINGS Shaheen, M. S., Silverberg, J. 2020; 41 (2): 112ā€“19

    Abstract

    Background: Previous studies that examined the relationship between asthma, osteoporosis, and pathologic fractures found conflicting results. Objective: To determine whether asthma is associated with osteopenia, osteoporosis, osteomalacia, and fractures in U.S. adults. Methods: A cross-sectional study of 198,102,435 children and adults, including 10,129,307 with asthma, from the 2006-2012 National Emergency Department Sample, which includes a representative 20% sample of emergency department (ED) visits throughout the United States. Results: ED visits of patients with versus without asthma were associated with higher odds of osteopenia (7 of 7 years: multivariable logistic regression of all years pooled; adjusted odds ratio [aOR] 1.45 [95% confidence interval {CI}, 1.41-1.50]), osteoporosis (7 of 7 years: aOR 1.85 [95% CI, 1.82-1.88]), osteomalacia (7 of 7 years: aOR 2.00 [95% CI, 1.61-2.49]), and pathologic fractures (7 of 7 years: OR 1.24 [95% CI, 1.20-1.27]). Patients with asthma and with long-term glucocorticoid use had higher odds of osteoporosis, osteopenia, osteomalacia, and fractures compared with patients with asthma and without long-term glucocorticoid use. Patients with asthma and with fractures incurred significantly more inpatient admissions, and higher costs of ED and inpatient care. Conclusion: ED visits with asthma were associated with osteopenia, osteoporosis, osteomalacia, and pathologic fractures.

    View details for DOI 10.2500/aap.2020.41.190035

    View details for Web of Science ID 000518467400009

    View details for PubMedID 32122447

  • Atopic dermatitis is associated with osteoporosis and osteopenia in older adults JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY Shaheen, M. S., Silverberg, J. I. 2019; 80 (2): 550ā€“51

    View details for DOI 10.1016/j.jaad.2018.05.026

    View details for Web of Science ID 000455473200036

    View details for PubMedID 29800580