Personalized Repetitive Transcranial Magnetic Stimulation for Depression.
Biological psychiatry. Cognitive neuroscience and neuroimaging
Personalized treatments are gaining momentum across all fields of medicine. Precision medicine can be applied to neuromodulatory techniques, in which focused brain stimulation treatments such as repetitive transcranial magnetic stimulation (rTMS) modulate brain circuits and alleviate clinical symptoms. rTMS is well tolerated and clinically effective for treatment-resistant depression and other neuropsychiatric disorders. Despite its wide stimulation parameter space (location, angle, pattern, frequency, and intensity can be adjusted), rTMS is currently applied in a one-size-fits-all manner, potentially contributing to its suboptimal clinical response (∼50%). In this review, we examine components of rTMS that can be optimized to account for interindividual variability in neural function and anatomy. We discuss current treatment options for treatment-resistant depression, the neural mechanisms thought to underlie treatment, targeting strategies, stimulation parameter selection, and adaptive closed-loop treatment. We conclude that a better understanding of the wide and modifiable parameter space of rTMS will greatly improve the clinical outcome.
View details for DOI 10.1016/j.bpsc.2022.10.006
View details for PubMedID 36792455
Spectral-Temporal Electrophysiological Features Predict Short-Term Plasticity in Humans Following Repetitive Stimulation
ELSEVIER SCIENCE INC. 2022: S202
View details for Web of Science ID 000789022200494
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