
Nathan Ng
MD Student with Scholarly Concentration in Clinical Research, expected graduation Spring 2023
All Publications
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DSC perfusion MRI-derived fractional tumor burden and relative CBV differentiate tumor progression and radiation necrosis in brain metastases treated with stereotactic radiosurgery.
American Journal of Neuroradiology
2022; 43 (5): 689-695
View details for DOI 10.3174/ajnr.A7501
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Brain iron assessment after ferumoxytol-enhanced MRI in children and young adults with arteriovenous malformations: a case-control study.
Radiology
2020; 297 (2): 438-446
View details for DOI 10.1148/radiol.2020200378
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Locoregional delivery of stem cell-based therapies.
Science Translational Medicine
2020; 12 (547): 1-17
View details for DOI 10.1126/scitranslmed.aba4564
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A deep learning-based system for survival benefit prediction of tyrosine kinase inhibitors and immune checkpoint inhibitors in stage IV non-small cell lung cancer patients: A multicenter, prognostic study
eClinicalMedicine
2022; 51: 1-14
View details for DOI 10.1016/j.eclinm.2022.101541
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Effects of age on white matter microstructure in children with neurofibromatosis type 1.
Journal of Child Neurology
2021; 36 (10): 894-900
View details for DOI 10.1177/08830738211008736
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Emerging role of stem cell-derived extravesicular microRNAs in age-associated human diseases and in different therapies of longevity.
Ageing Research Reviews
2020; 57: 1-14
View details for DOI 10.1016/j.arr.2019.100979
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Development and validation of a machine learning model to explore tyrosine kinase inhibitor response in patients with stage IV EGFR variant-positive non-small cell lung cancer.
JAMA Network Open
2020; 3 (12): 1-13
View details for DOI 10.1001/jamanetworkopen.2020.30442
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Cerebral volume and diffusion MRI changes in children with sensorineural hearing loss.
NeuroImage: Clinical
2020; 27: 1-9
View details for DOI 10.1016/j.nicl.2020.102328
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Association of pediatric acute-onset neuropsychiatric syndrome with microstructural differences in brain regions detected via diffusion-weighted magnetic resonance imaging.
JAMA Network Open
2020; 3 (5): 1-15
View details for DOI 10.1001/jamanetworkopen.2020.4063
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Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation.
Neurobiology of Disease
2020; 134: 1-16
View details for DOI 10.1016/j.nbd.2019.104627
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Mesenchymal stem cells confer chemoresistance in breast cancer via a CD9 dependent mechanism.
Oncotarget
2019; 10 (37): 3435-3450
Abstract
The development of chemotherapy drug resistance remains a significant barrier for effective therapy in several cancers including breast cancer. Bone marrow-derived mesenchymal stem cells (BMMSCs) have previously been shown to influence tumor progression and the development of chemoresistance. In the present study, we showed that when GFP labelled BMMSCs and RFP labelled HCC1806 cells are injected together in vivo, they create tumors which contain a new hybrid cell that has characteristics of both BMMSCs and HCC1806 cells. By labelling these cells prior to their injection, we were then able to isolate new hybrid cell from harvested tumors using FACS (DP-HCC1806:BMMSCs). Interestingly, when DP-HCC1806:BMMSCs were then injected into the mammary fat pad of NOD/SCID mice, they produced xenograft tumors which were smaller in size, and exhibited resistance to chemotherapy drugs (i.e. doxorubicin and 5-fluorouracil), when compared tumors from HCC1806 cells alone. This chemoresistance was shown to associated with an increased expression of tetraspanins (CD9, CD81) and drug resistance proteins (BCRP, MDR1). Subsequent siRNA-mediated knockdown of BMMSC-CD9 in DP-HCC1806:BMMSCs resulted in an attenuation of doxorubicin and 5-fluorouracil chemoresistance associated with decreased BCRP and serum cytokine expression (CCL5, CCR5, CXCR12). Our findings suggest that within the tumor microenvironment, CD9 is responsible for the crosstalk between BMMSCs and HCC1806 breast cancer cells (via CCL5, CCR5, and CXCR12) which contributes to chemoresistance. Hence, BMMSC-CD9 may serve as an important therapeutic target for the treatment of breast cancer.
View details for DOI 10.18632/oncotarget.26952
View details for PubMedID 31191817
View details for PubMedCentralID PMC6544397
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Reproducible and efficient generation of functionally active neurons from human iPSCs for preclinical disease modeling.
Stem Cell Research
2018; 26: 84-94
View details for DOI 10.1016/j.scr.2017.12.003
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Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons.
Journal of Neuroscience Methods
2018; 294: 91-101
View details for DOI 10.1016/j.jneumeth.2017.07.019
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Research Associates Program: Expanding clinical research productivity with undergraduate students.
SAGE Open Medicine
2017; 5: 1-7
View details for DOI 10.1177/2050312117730245