Noah Eckman

All Publications

• Label-Free Composition Analysis of Supramolecular Polymer - Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector. bioRxiv : the preprint server for biology Tang, S., Pederson, Z., Meany, E. L., Yen, C., Swansiger, A. K., Prell, J. S., Chen, B., Grosskopf, A. K., Eckman, N., Jiang, G., Baillet, J., Pellett, J. D., Appel, E. A. 2023

  Abstract

  Supramolecular hydrogels formed through polymer-nanoparticle interactions are promising biocompatible materials for translational medicines. This class of hydrogels exhibits shear-thinning behavior and rapid recovery of mechanical properties following applied stresses, providing desirable attributes for formulating sprayable and injectable therapeutics. Characterization of hydrogel composition and loading of encapsulated drugs is critical to achieving desired rheological behavior as well as tunable in vitro and in vivo payload release kinetics. However, quantitation of hydrogel compositions is challenging due to material complexity, heterogeneity, high molecular weight, and the lack of chromophores. Here, we present a label-free approach to simultaneously determine hydrogel polymeric components and encapsulated payloads by coupling a reversed phase liquid chromatographic method with a charged aerosol detector (RPLC-CAD). The hydrogel studied consists of modified hydroxypropylmethylcellulose, self-assembled PEG-b-PLA nanoparticles, and a therapeutic compound, Bimatoprost. The three components were resolved and quantitated using the RPLC-CAD method with a C4 stationary phase. The method demonstrated robust performance, applicability to alternative cargos (i.e. proteins), and was suitable for composition analysis as well as for evaluating in vitro release of cargos from the hydrogel. Moreover, this method can be used to monitor polymer degradation and material stability, which can be further elucidated by coupling the RPLC method with high resolution mass spectrometry and a Fourier-transform based deconvolution algorithm. To our knowledge, this is the first RPLC-CAD method for characterizing the critical quality attributes of supramolecular hydrogels. We envision this analytical strategy could be generalized to characterize other classes of supramolecular hydrogels, establish structure-property relationships, and provide rational design guidance in hydrogel drug product development.

  View details for DOI 10.1101/2023.08.11.553055

  View details for PubMedID 37609276

• A Regimen Compression Strategy for Commercial Vaccines Leveraging an Injectable Hydrogel Depot Technology for Sustained Vaccine Exposure ADVANCED THERAPEUTICS Yan, J., Ou, B. S., Saouaf, O. M., Meany, E. L., Eckman, N., Appel, E. A. 2023

  View details for DOI 10.1002/adtp.202300108

  View details for Web of Science ID 001004577500001

• A freely suspended robotic swimmer propelled by viscoelastic normal stresses JOURNAL OF FLUID MECHANICS Kroo, L. A., Binagia, J. P., Eckman, N., Prakash, M., Shaqfeh, E. G. 2022; 944

  View details for DOI 10.1017/jfm.2022.485

  View details for Web of Science ID 000817205500001

• In Situ Direct Laser Writing of 3D Graphene-Laden Microstructures ADVANCED MATERIALS TECHNOLOGIES Restaino, M., Eckman, N., Alsharhan, A. T., Lamont, A. C., Anderson, J., Weinstein, D., Hall, A., Sochol, R. D. 2021; 6 (8)

  View details for DOI 10.1002/admt.202100222

  View details for Web of Science ID 000663380000001

• Ignition and combustion analysis of direct write fabricated aluminum/metal oxide/PVDF films COMBUSTION AND FLAME Rehwoldt, M. C., Wang, H., Kline, D. J., Wu, T., Eckman, N., Wang, P., Agrawal, N. R., Zachariah, M. R. 2020; 211: 260-269

  View details for DOI 10.1016/j.combustflame.2019.08.023

  View details for Web of Science ID 000503319100022

• Why does adding a poor thermal conductor increase propagation rate in solid propellants? APPLIED PHYSICS LETTERS Kline, D. J., Rehwoldt, M. C., Wang, H., Eckman, N. E., Zachariah, M. R. 2019; 115 (11)

  View details for DOI 10.1063/1.5113612

  View details for Web of Science ID 000486002700007

• Direct Writing of a 90 wt% Particle Loading Nanothermite ADVANCED MATERIALS Wang, H., Shen, J., Kline, D. J., Eckman, N., Agrawal, N. R., Wu, T., Wang, P., Zachariah, M. R. 2019; 31 (23): e1806575

  Abstract

  The additive manufacturing of energetic materials has received worldwide attention. Here, an ink formulation is developed with only 10 wt% of polymers, which can bind a 90 wt% nanothermite using a simple direct-writing approach. The key additive in the ink is a hybrid polymer of poly(vinylidene fluoride) (PVDF) and hydroxy propyl methyl cellulose (HPMC) in which the former serves as an energetic initiator and a binder, and the latter is a thickening agent and the other binder, which can form a gel. The rheological shear-thinning properties of the ink are critical to making the formulation at such high loadings printable. The Young's modulus of the printed stick is found to compare favorably with that of poly(tetrafluoroethylene) (PTFE), with a particle packing density at the theoretical maximum. The linear burn rate, mass burn rate, flame temperature, and heat flux are found to be easily adjusted by varying the fuel/oxidizer ratio. The average flame temperatures are as high as ≈2800 K with near-complete combustion being evident upon examination of the postcombustion products.

  View details for DOI 10.1002/adma.201806575

  View details for Web of Science ID 000474087100019

  View details for PubMedID 30993751