Dr. Orlando Quintero is a board-certified, fellowship trained internist specializing in the diagnosis and treatment of infectious diseases. He is also clinical assistant professor in the Department of Medicine, Division of Infectious Diseases, at Stanford University School of Medicine.
As a clinician, Dr. Quintero diagnoses and treats infectious diseases in immunocompromised patients. This includes the prevention, diagnosis and treatment of infections in patients who are immunosuppressed because of Solid Organ Transplantation, Bone Marrow (Hematopoeitic Cell) Transplants, Hematologic Malignancies, Chemotherapy for Solid Tumors, HIV who receive Chemotherapy, Solid Organ or Bone Marrow Transplants Immunomodulators for Auto-Immune Diseases and other forms of immunodeficiency.
Dr. Quintero has published on topics including coronavirus in kidney transplant patients, prevention of cytomegalovirus in heart transplant patients, and prevention of urinary tract infections in renal transplant patients. His work has appeared in publications including Transplant Infectious Disease, Emerging Infectious Diseases, and the Journal of Heart and Lung Transplantation.
He has delivered presentations at meetings of organizations including the International Society for Heart and Lung Transplantation, Interscience Conference on Antimicrobial Agents and Chemotherapy, and American Society of Tropical Medicine and Hygiene. Topics of his presentations have included prevention of cytomegalovirus, prevention of recurrent urinary tract infections, Chagas disease in New York City, and more.
Currently, Dr. Quintero is conducting research on treatment of patients with COVID-19, prevention and treatment of invasive fungal infections of the gastrointestinal tract in immunocompromised patients, and the epidemiology of invasive fungal infections in heart transplant recipients.
Among his awards, He has received honors for his teaching and research from Albert Einstein College. He also has earned recognition from the Fred Hutchinson Cancer Research Center and the American Society of Transplantation.
Dr. Quintero’s volunteer community service includes participation in health fairs to promote HIV testing and hypertension control, plus disease management in the Garifuna population in New York – descendants of an Afro-indigenous population from the Caribbean island of St. Vincent.
He is a member of the Infectious Disease Society of American, Infectious Diseases Association of California, American Society of Transplantation, and HIV Medicine Association.
- Internal Medicine
- Infectious Diseases
- Immunocompromised Host Infectious Diseases
Clinical Assistant Professor, Medicine - Infectious Diseases
Clinical Assistant Professor, Department of Medicine, Division of Infectious Diseases (2020 - Present)
Honors & Awards
Teaching Fellow of the Year, Montefiore Medical Center - Albert Einstein College (2017-2019)
Best Overall House Staff PGY3, Internal Medicine Residency Program, Jacobi Medical center - Albert Einstein College (2016-2017)
Best Original Research Award, Milford Fulop Poster Competition, Jacobi Medical Center-Albert Einstein College of Medicine (2016)
Infectious Diseases in the Immunocompromised Host Travel Award, Fred Hutch Symposium (2019)
Travel Award, American Society of Transplantation (2018)
Boards, Advisory Committees, Professional Organizations
Member, HIV Medicine Association (2016 - Present)
Member, Infectious Disease Society of America (IDSA) (2016 - Present)
Member, American Society of Transplantation (2018 - Present)
Member, Infectious Disease Association of California (2019 - Present)
Fellowship: Stanford University Infectious Disease Fellowships (2020) CA
Board Certification: American Board of Internal Medicine, Infectious Disease (2019)
Fellowship: Montefiore Medical Ctr Infectious Disease Program (2019) NY
Board Certification: American Board of Internal Medicine, Internal Medicine (2017)
Residency: Jacobi Medical Center Internal Medicine Residency (2017) NY
Medical Education: Universidad Libre de Cali (2010) Colombia
Community and International Work
Volunteer Physician, Nariño, Colombia
Departamento de Salud de Nariño La Union
Opportunities for Student Involvement
Health fairs to help promote HIV testing, DM and HTN control, Bronx, New York, NY
Garifuna population in the Bronx, New York, NY
Opportunities for Student Involvement
Peginterferon Lambda-1a for treatment of outpatients with uncomplicated COVID-19: a randomized placebo-controlled trial.
2021; 12 (1): 1967
Type III interferons have been touted as promising therapeutics in outpatients with coronavirus disease 2019 (COVID-19). We conducted a randomized, single-blind, placebo-controlled trial (NCT04331899) in 120 outpatients with mild to moderate COVID-19 to determine whether a single, 180 mcg subcutaneous dose of Peginterferon Lambda-1a (Lambda) within 72 hours of diagnosis could shorten the duration of viral shedding (primary endpoint) or symptoms (secondary endpoint). In both the 60 patients receiving Lambda and 60 receiving placebo, the median time to cessation of viral shedding was 7 days (hazard ratio [HR] = 0.81; 95% confidence interval [CI] 0.56 to 1.19). Symptoms resolved in 8 and 9 days in Lambda and placebo, respectively, and symptom duration did not differ significantly between groups (HR 0.94; 95% CI 0.64 to 1.39). Both Lambda and placebo were well-tolerated, though liver transaminase elevations were more common in the Lambda vs. placebo arm (15/60 vs 5/60; p = 0.027). In this study, a single dose of subcutaneous Peginterferon Lambda-1a neither shortened the duration of SARS-CoV-2 viral shedding nor improved symptoms in outpatients with uncomplicated COVID-19.
View details for DOI 10.1038/s41467-021-22177-1
View details for PubMedID 33785743
Chagas Disease in the New York City Metropolitan Area
OPEN FORUM INFECTIOUS DISEASES
2020; 7 (5): ofaa156
Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chagas disease among the medical community in the United States is poor.We review our experience managing 60 patients with Chagas disease in hospitals throughout the New York City metropolitan area and describe screening, clinical manifestations, EKG findings, imaging, and treatment.The most common country of origin of our patients was El Salvador (n = 24, 40%), and the most common detection method was by routine blood donor screening (n = 21, 35%). Nearly half of the patients were asymptomatic (n = 29, 48%). Twenty-seven patients were treated with either benznidazole or nifurtimox, of whom 7 did not complete therapy due to side effects or were lost to follow-up. Ten patients had advanced heart failure requiring device implantation or organ transplantation.Based on our experience, we recommend that targeted screening be used to identify at-risk, asymptomatic patients before progression to clinical disease. Evaluation should include an electrocardiogram, echocardiogram, and chest x-ray, as well as gastrointestinal imaging if relevant symptoms are present. Patients should be treated if appropriate, but providers should be aware of adverse effects that may prevent patients from completing treatment.
View details for DOI 10.1093/ofid/ofaa156
View details for Web of Science ID 000553470400042
View details for PubMedID 32500090
View details for PubMedCentralID PMC7255644
Moving towards an Induction-Free Era: Short-Term Renal and Infectious Outcomes
ELSEVIER SCIENCE INC. 2020: S274–S275
View details for Web of Science ID 000522637202019
6-month vs 12-month CMV Prophylaxis for CMV-Mismatched Heart Transplant Recipients
ELSEVIER SCIENCE INC. 2020: S204–S205
View details for Web of Science ID 000522637201177
- Methenamine hippurate may have particular benefit in preventing recurrent urinary tract infections in diabetic renal transplant recipients TRANSPLANT INFECTIOUS DISEASE 2020: e13247
Influence of Immunosuppression on Seroconversion Against SARS-Cov-2 in Two Kidney Transplant Recipients.
Transplant infectious disease : an official journal of the Transplantation Society
Solid organ transplant recipients are at risk for infectious complications due to chronic immunosuppression. The outbreak of Coronavirus Disease 2019 (COVID-19) in United States has raised growing concerns for the transplant patient population. We seek to add to the current limited literature on COVID-19 in transplant recipients by describing the clinical course of two kidney transplant recipients with SARS-Cov-2 infection monitored by both RT-PCR and serology. Through careful adjustment of their immunosuppression regimen, both patients had excellent recovery with intact graft function and development of anti-SARS-Cov-2 antibodies.
View details for DOI 10.1111/tid.13423
View details for PubMedID 32701196
Characteristics and outcomes of coronavirus disease patients under nonsurge conditions, northern California, USA, March–April 2020
Emerging Infectious Diseases
Limited data are available on the clinical presentation and outcomes of coronavirus disease (COVID-19) patients in the United States hospitalized under normal-caseload or nonsurge conditions. We retrospectively studied 72 consecutive adult patients hospitalized with COVID-19 in 2 hospitals in the San Francisco Bay area, California, USA, during March 13-April 11, 2020. The death rate for all hospitalized COVID-19 patients was 8.3%, and median length of hospitalization was 7.5 days. Of the 21 (29% of total) intensive care unit patients, 3 (14.3% died); median length of intensive care unit stay was 12 days. Of the 72 patients, 43 (59.7%) had underlying cardiovascular disease and 19 (26.4%) had underlying pulmonary disease. In this study, death rates were lower than those reported from regions of the United States experiencing a high volume of COVID-19 patients.
View details for DOI 10.3201/eid2608.201776
Risk factors of laryngeal cryptococcosis: A case report
MEDICAL MYCOLOGY CASE REPORTS
2019; 24: 82–85
Cryptococcal infections are acquired by inhalation of encapsulated yeast cells or basidiospores. While Cryptococcus has a propensity to invade the lungs and central nervous system, other sites can be affected. Laryngeal cryptococcosis is rare with less than 30 previously reported cases, which commonly occurred in apparently immunocompetent hosts on inhaled corticosteroids. We present a case of laryngeal cryptococcosis with a long-term inhaled corticosteroid use, co-infection of pulmonary Mycobacterium avium-intracellulare, and mannose-binding lectin deficiency.
View details for DOI 10.1016/j.mmcr.2019.04.009
View details for Web of Science ID 000468128500023
View details for PubMedID 31080714
View details for PubMedCentralID PMC6506557