Bio
I am a Postdoctoral Researcher at Stanford University, California, United States of America (CA, USA). I am passionate about using my skills and research knowledge to impact the world positively. I believe that my research has the potential to help us address some of the world's most pressing challenges at a worldwide level. I am excited to continue my research and contribute to developing novel technologies and novel drug delivery carrier systems to help us create a more sustainable future.
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Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells.
Nature communications
2025; 16 (1): 7055
Abstract
RNA medicine is an emerging groundbreaking technology for the prevention and treatment of disease. However, tools to deliver messenger RNA (mRNA) and other polyanions (circRNA, saRNA, pDNA, CRISPR-Cas, reprogramming factors) are required to advance current RNA therapies and address next generation challenges. Existing delivery systems often suffer from laborious syntheses, limited organ selectivity, formulation complexity, and undesired inflammatory responses. Here, we report novel mRNA delivery systems termed Discrete Immolative Guanidinium Transporters (DIGITs), which are synthesized convergently in as few as 4 steps. Unlike most cationic (ammonium) delivery systems, DIGITs are based on cationic guanidinium moieties, which complex mRNA at acidic pH and undergo irreversible neutralization at physiological pH to enable efficient RNA release. Systematic evaluation of structural variations and formulations have led to DIGIT/mRNA complexes that selectively target lung, spleen, and immature red blood cells in peripheral blood in female mice model. DIGIT/mRNA delivery systems show minimal toxicity based on cell viability and biochemical assays, supporting their future utility in biomedical applications.
View details for DOI 10.1038/s41467-025-62200-3
View details for PubMedID 40750796