Prerak Juthani

All Publications

• Hospital leadership training should start in medical school. Medical education Luo, A. D., Juthani, P. V., Rens, N., Ryu, J. 2024

  View details for DOI 10.1111/medu.15350

  View details for PubMedID 38366685

• Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era. The Lancet. Microbe Wang, S. Y., Juthani, P. V., Borges, K. A., Shallow, M. K., Gupta, A., Price, C., Won, C. H., Chun, H. J. 2022; 3 (1): e4-e5

  View details for DOI 10.1016/S2666-5247(21)00306-2

  View details for PubMedID 34901896

  View details for PubMedCentralID PMC8641954

• Documenting The Clinical Course Of Breakthrough Covid-19 Infections Among Fully Vaccinated Patients Yale Medicine Thesis Digital Library Juthani, P. 2022
• Hospitalisation among vaccine breakthrough COVID-19 infections. The Lancet. Infectious diseases Juthani, P. V., Gupta, A., Borges, K. A., Price, C. C., Lee, A. I., Won, C. H., Chun, H. J. 2021; 21 (11): 1485-1486

  View details for DOI 10.1016/S1473-3099(21)00558-2

  View details for PubMedID 34506735

  View details for PubMedCentralID PMC8423430

• Optimizing preclinical learning with retrieval practice: A call to action. Medical teacher Ahmed, O. M., Juthani, P. V., Green, M. L., Moeller, J. J. 2021; 43 (6): 718-720

  Abstract

  This Personal View is about our experience with preclinical education as medical students. We discuss the problem with current medical education in light of an ever-growing body of medical knowledge and increasing student disengagement with preclinical lectures. We briefly review the concept of retrieval practice as an effective, evidence-based learning strategy that helped us retain knowledge for longer periods and propose that medical educators should adopt this strategy to best prepare medical students to navigate the vastly expanding scope of modern medicine.

  View details for DOI 10.1080/0142159X.2020.1788212

  View details for PubMedID 32643504

• The Emotional Impact of Educational Productivity Videos on YouTube: A Global, Cross-Sectional Survey. Cureus Andersen, S., Patel, D., Nguyen, A., Juthani, P., Hussain, K., Chen, J., Rutkowski, M. 2023; 15 (8): e43989

  Abstract

  Introduction YouTube is the most popular video-sharing website, and many students use it as a resource to find educational content. One type of video category is "productivity," in which the creator teaches viewers how to lead a more productive lifestyle by sharing ways to maximize studying, reshape daily habits, or set achievable goals. Little research has been conducted on whether these videos actually promote positive or negative feelings among viewers. Methods A survey was created through Qualtrics and shared through YouTube and Instagram. The survey asked about exposure to productivity videos and also asked individuals to share their experiences with consuming productivity-related educational content on YouTube. Survey items asked students to rate the helpfulness of these videos and share their feelings about the content. Respondents were asked to share whether YouTube videos on productivity made them feel anxious, motivated, inspired, neutral/indifferent, or inadequate. Participants were also asked to rate how helpful they found productivity videos on YouTube (1-10, with 10 being most helpful). The survey included free response sections to assess viewers' perceptions and attitudes toward productivity videos. Results The cross-sectional survey amassed 595 responses across 60 countries, with 364 responses coming from individuals within the United States. Of the respondents, 397 of the respondents were female, 177 were male, and 21 preferred not to say or identified as non-binary. The average age of participants was 22 years; 79 were in high school, 174 were in college, 223 were in medical school, and the remainder identified as "other" (graduate school, gap year, etc.). Of the 595 completed responses, 494 reported watching videos on YouTube related to improving productivity; when asked how these videos made them feel, 127 participants answered "anxious," 357 answered "motivated," 308 answered "inspired," 95 answered "neutral/indifferent," and 97 answered "inadequate." When rating how helpful they found these videos (1-10), an average score of 6.8 was recorded. Conclusion Most viewers feel motivated or inspired by productivity videos on YouTube. Based on the free responses provided by survey participants, productivity videos can be made more effective by showing more relatable routines and demonstrating what viewers should do when goals are not met.

  View details for DOI 10.7759/cureus.43989

  View details for PubMedID 37746481

  View details for PubMedCentralID PMC10516449

• Lange Flashcards: Pharmacology Baron, S. J., Lee, C., Juthani, P., Tyagi, S. McGraw-Hill. In Press. 2023 (5th Edition):
• Psychological Attachment Orientation and Long-Term Posttraumatic Stress Symptoms Among Family Members of ICU Patients. Critical care explorations Zhang, Q., Knies, A. K., Pach, J., Kimbrough, T., Martinez, A., Juthani, P., Tu, S., Monin, J. K., Vranceanu, A. M., Hwang, D. Y. 2022; 4 (9): e0753

  Abstract

  To determine the degree to which an ICU patient's family member having an "anxious" psychologic attachment orientation is a risk factor for developing long-term posttraumatic stress disorder (PTSD) symptoms following patient ICU discharge or death.Prospective cohort study.Single academic neuroscience ICU from November 2017 to September 2020.Consecutively enrolled sample of family members, one for each ICU patient with a minimum length of stay of 24 hours.None.Near time of ICU discharge or patient death, we determined each participant's psychologic attachment orientation as anxious versus nonanxious via a brief standard survey tool, the Relationship Questionnaire, and measured other participant and patient characteristics as potential covariates. Six months after discharge or death, each participant completed the Impact of Events Scale-Revised (IES-R) to measure PTSD symptoms, with a score of greater than 24 indicative of clinically significant symptoms. Among 162 total participants, 10 of 27 participants (37.0%) with an anxious attachment orientation reported 6-month PTSD symptoms, compared with 24 of 135 nonanxious participants (17.8%) (relative risk, 2.08; 95% CI, 1.13-3.84; p = 0.02; risk difference 19.2%). In a subsequent univariate analysis of participant and patient covariates, anxious attachment orientation, participant Hispanic ethnicity, prior experience as a care partner of a patient with a disability, and participation in 3 or more formal ICU family meetings were all associated with 6-month PTSD symptoms. In a multiple logistic regression, anxious attachment remained an independent predictor of 6-month PTSD symptoms (odds ratio [OR], 3.64; 95% CI, 1.35-9.77; p = 0.01), as did Hispanic ethnicity (OR, 4.72; 95% CI, 1.34-16.6; p = 0.01) and participation in three or more ICU family meetings (odds ratio, 2.97; 95% CI, 1.14-7.68; p = 0.02).An anxious psychologic attachment orientation is associated with double the risk of long-term PTSD symptoms among family members of ICU patients. Future interventions designed to decrease risk of adverse psychologic outcomes among ICU families could be initially tested for efficacy amongst those who fall into this high-risk category.

  View details for DOI 10.1097/CCE.0000000000000753

  View details for PubMedID 36050994

  View details for PubMedCentralID PMC9426807

• A Needs Assessment and Patient and Physician Guided Development of Video-Based Diabetic Retinopathy Patient Education Ahmed, O., Applebaum, S., Ahmad, M., Ahmed, D., Juthani, P., Nwanyanwu, K. Social Science Research Network. 2022
• Proteomic Profiles in Patients with Thrombosis Due to COVID-19 Are Distinct from Non-COVID-19 Thrombosis Madeeva, D. V., Borges, K., Shallow, M., Juthani, P. V., Wang, S. Y., Gupta, A., Chun, H. J., Lee, A., Pine, A. B. AMER SOC HEMATOLOGY. 2021

  View details for DOI 10.1182/blood-2021-153959

  View details for Web of Science ID 000736398803076

• PCSK9 Inhibiting Monoclonal Antibodies Stroke Revisited: Dyslipidemia in Stroke Ahmed, Z., Juthani, P., Lee, M., Desai, N. Springer Singapore. 2021; 1: 125-133

  View details for DOI 10.1007/978-981-16-3923-4_11

• Factors associated with health-related quality of life in patients with cirrhosis: a systematic review. Liver international : official journal of the International Association for the Study of the Liver Rabiee, A., Ximenes, R. O., Nikayin, S., Hickner, A., Juthani, P., Rosen, R. H., Garcia-Tsao, G. 2021; 41 (1): 6-15

  Abstract

  Patients with cirrhosis have a poor health-related quality of life (HRQoL). Recognizing factors that affect HRQoL is key in delivering patient-centred care.To identify factors most commonly associated with a poor HRQoL in adults with cirrhosis in a systematic review of the literature.Four databases (MEDLINE, EMBASE, CENTRAL and PsycINFO) were searched from inception to March 2020, using terms related to patient-reported outcomes plus cirrhosis. Studies that analysed an association between at least one factor and HRQoL in adult patients with cirrhosis were included. Abstract and full-text screening was performed by two reviewers. Data were collected on factors evaluated in each study and the significance of their association with HRQoL.A total of 10647 citations were reviewed, of which 109 met eligibility criteria. 76% of the studies used a generic instrument while only 45% used liver-specific instruments. Among identified factors, demographic factors and cirrhosis aetiology were not generally associated with poor HRQoL except for poor social support. Depression, poor sleep and muscle cramps affected HRQoL in all the studies that evaluated them. Among comorbidities, frailty, falls, malnutrition and cognitive impairment were also associated with poor HRQoL in the majority of studies. Among cirrhosis-specific decompensating events, only hepatic encephalopathy (HE) was consistently associated with impairment in HRQoL (75% of studies).Many factors impact poor HRQoL in patients with cirrhosis such as depression, muscle cramps, poor sleep, falls, frailty and malnutrition. Among cirrhosis decompensating events, HE was the complication most commonly associated with a poor HRQoL.

  View details for DOI 10.1111/liv.14680

  View details for PubMedID 32998172

• Coronavirus Disease 2019 (COVID-19) Manifestation as Acute Myocardial Infarction in a Young, Healthy Male. Case reports in infectious diseases Juthani, P., Bhojwani, R., Gupta, N. 2020; 2020: 8864985

  Abstract

  Although a large part of the symptomology of coronavirus disease 2019 (COVID-19) has been attributed to its effects in the lungs, the virus has also been shown to cause extensive cardiovascular complications in a small subset of patients. In this case report, we describe a 29-year-old nonobese hospital food service associate who presented with diffuse abdominal and chest pain; he was found to be positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significantly elevated levels of troponin T and multiple acute phase reactants; his EKG demonstrated ST-elevations consistent with anterolateral infarction. Despite having no significant past medical history or atherosclerotic risk factors, he was found to have a complete occlusion of his left anterior descending artery that required cardiac catheterization. This case demonstrates that cardiovascular complications must be considered in the COVID-19 population, even without the clear presence of other risk factors for heart disease.

  View details for DOI 10.1155/2020/8864985

  View details for PubMedID 32724685

  View details for PubMedCentralID PMC7364231

• Psychological Attachment Orientations of Surrogate Decision-Makers and Goals-of-Care Decisions for Brain Injury Patients in ICUs. Critical care explorations Knies, A. K., Zhang, Q., Juthani, P., Tu, S., Pach, J., Martinez, A., Monin, J. K., Hwang, D. Y. 2020; 2 (7): e0151

  Abstract

  To determine whether ICU surrogates with "insecure" psychologic attachment orientations are more prone to requesting tracheostomy and gastrostomy (i.e., life-sustaining therapy) for severe acute brain injury patients with poor prognosis compared to surrogates with "secure" orientations.Cross-sectional survey from November 2017 to August 2018.Single neuroscience ICU at an academic medical center.Consecutive sample of surrogates of patients admitted to the ICU with a minimum length of stay of 24 hours.None.We identified surrogates' psychologic attachment orientation via a standard tool, the Relationship Questionnaire, and collected other surrogate and patient demographics. We also presented surrogates with a hypothetical scenario of an intubated severe acute brain injury patient with poor prognosis and asked each surrogate whether he or she would request life-sustaining therapy or comfort measures only. Fisher exact test was used to compare frequency of life-sustaining therapy selection between secure and insecure surrogates. Additionally, we conducted univariate and multivariate analyses to determine other independent predictors of life-sustaining therapy selection. Two-hundred seventy-five of 713 (38.6%) eligible respondents participated; 153 (55.6%) surrogates were secure, and 122 (44.4%) insecure. There was no significant difference in the proportion of secure respondents selecting life-sustaining therapy compared to insecure (18.3% vs 20.5%; p = 0.38). Although still nonsignificant, the observed difference was slightly greater for those with a specific "anxious" insecure subtype versus "nonanxious" (18.2% vs 23.0%; p = 0.41). Overall, a higher proportion of respondents selecting life-sustaining therapy (vs comfort measures only) reported feeling uncertain or very uncertain about the hypothetical decision (45.3% vs 9.5%; p < 0.001). In a multivariate model, nonwhite race and high religiosity were significant predictors of life-sustaining therapy selection.Although surrogate attachment orientation is not predictive of life-sustaining therapy selection, nonwhite race and high religiosity are. Future interventions designed to support severe acute brain injury surrogates could focus on surrogates prone to selecting life-sustaining therapy with high degrees of uncertainty.

  View details for DOI 10.1097/CCE.0000000000000151

  View details for PubMedID 32696015

  View details for PubMedCentralID PMC7340333

• An online curriculum in movement disorders for neurology housestaff. Clinical parkinsonism & related disorders Schaefer, S. M., Vadlamani, L., Juthani, P., Louis, E. D., Patel, A., Tinaz, S., Rodriguez, A. V., Moeller, J. J. 2020; 3: 100035

  Abstract

  In many neurology residency programs, outpatient neurology subspecialties are underrepresented. Trainee exposure to these subspecialties, including movement disorders, is limited by paucity and variability of clinical experiences. We designed a structured educational tool to address this variability and allow for standardization of elements of movement disorders teaching.We designed and implemented a web-based curriculum in movement disorders for neurology housestaff, in order to improve participant knowledge. The curriculum includes an introduction with a structured framework for the description of abnormal movements and 10 interactive modules focusing on common movement disorders. The curriculum was piloted with nine neurology housestaff at Yale-New Haven Hospital. Evaluation of the curriculum was performed using pre- and post-tests, a survey, and semi-structured interviews.The mean pre-test score was 0.7 (±0.19), and the mean post-test score was 0.95 (±0.05) (t = 3.27). Surveys demonstrated mean Likert values >4/5 for all questions in all categories (knowledge acquisition, quantity, enthusiasm and technical). Semi-structured interviews revealed the following themes: 1) the modules increased participant comfort with the topic, 2) the format was engaging, and 3) the curriculum accommodated different learning styles. All participants remarked that the structured framework was a particular strength.We have created, implemented, and evaluated a foundational curriculum in movement disorders for neurology trainees, using readily-available technology. Housestaff responded positively to the curriculum, both in terms of content and format. This curriculum can be implemented in a variety of educational settings, as a central component of a standardized approach to movement disorders teaching.

  View details for DOI 10.1016/j.prdoa.2020.100035

  View details for PubMedID 34316621

  View details for PubMedCentralID PMC8298796

• A Needs Assessment and Development of Video-based Diabetic Retinopathy Patient Education The Association for Research in Vision and Ophthalmology Annual Conference Ahmed, O., Ahmed, M., Juthani, P., Nwanyanwu, K. 2020
• PSYCHOLOGICAL ATTACHMENT STYLES OF SURROGATE DECISION-MAKERS AND ICU GOALS-OF-CARE DECISIONS Martinez, A., Knies, A., Juthani, P., Kimbrough, T., Pach, J., Hwang, D. LIPPINCOTT WILLIAMS & WILKINS. 2019

  View details for Web of Science ID 000498593401089

• Venous Thromboembolism (VTE) Education Preferences Amongst Physicians and Patients: A Qualitative Needs Assessment The American Society of Hematology Conference Juthani, P., Ahmed, D., Ahmed, O., Bona, R., Neparidze, N., Lee, A. 2018

  View details for DOI 10.1182/blood-2018-99-119418

• PqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway. The Journal of biological chemistry Latham, J. A., Iavarone, A. T., Barr, I., Juthani, P. V., Klinman, J. P. 2015; 290 (20): 12908-18

  Abstract

  Pyrroloquinoline quinone (PQQ) is a product of a ribosomally synthesized and post-translationally modified pathway consisting of five conserved genes, pqqA-E. PqqE is a radical S-adenosylmethionine (RS) protein with a C-terminal SPASM domain, and is proposed to catalyze the formation of a carbon-carbon bond between the glutamate and tyrosine side chains of the peptide substrate PqqA. PqqD is a 10-kDa protein with an unknown function, but is essential for PQQ production. Recently, in Klebsiella pneumoniae (Kp), PqqD and PqqE were shown to interact; however, the stoichiometry and KD were not obtained. Here, we show that the PqqE and PqqD interaction transcends species, also occurring in Methylobacterium extorquens AM1 (Me). The stoichiometry of the MePqqD and MePqqE interaction is 1:1 and the KD, determined by surface plasmon resonance spectroscopy (SPR), was found to be ∼12 μm. Moreover, using SPR and isothermal calorimetry techniques, we establish for the first time that MePqqD binds MePqqA tightly (KD ∼200 nm). The formation of a ternary MePqqA-D-E complex was captured by native mass spectrometry and the KD for the MePqqAD-MePqqE interaction was found to be ∼5 μm. Finally, using a bioinformatic analysis, we found that PqqD orthologues are associated with the RS-SPASM family of proteins (subtilosin, pyrroloquinoline quinone, anaerobic sulfatase maturating enzyme, and mycofactocin), all of which modify either peptides or proteins. In conclusion, we propose that PqqD is a novel peptide chaperone and that PqqD orthologues may play a similar role in peptide modification pathways that use an RS-SPASM protein.

  View details for DOI 10.1074/jbc.M115.646521

  View details for PubMedID 25817994

  View details for PubMedCentralID PMC4432305