All Publications

  • A Unique Case of Pediatric Orbital Nodular Fasciitis with a Confirmed USP6 Fusion Mutation. Ophthalmic plastic and reconstructive surgery Frauches, R. L., Roozdar, P., Lin, J. H., Homer, N. A. 2025

    Abstract

    Nodular fasciitis is a benign, pseudoneoplastic condition often misdiagnosed as sarcoma due to its rapid growth, high cellularity, and mitotic activity. Herein is reported a case of a 7-year-old patient with a painless, enlarging nodule in the left superolateral orbit. Ultrasound revealed a 7.5 mm cystic mass, which was excised via an upper eyelid crease anterior orbitotomy. Histopathologic studies showed benign spindle cells, and molecular testing identified a UBC::USP6 fusion, confirming the diagnosis of nodular fasciitis. Nodular fasciitis is most common in the limbs, trunk, and head or neck region, with fewer than 1% of cases occurring in the orbit. Molecular testing is critical in differentiating this condition from malignancies. Complete surgical excision is the preferred treatment, with a low recurrence rate of 1% to 2%. This is the first reported pediatric case of orbital nodular fasciitis with a UBC::USP6 fusion mutation.

    View details for DOI 10.1097/IOP.0000000000002981

    View details for PubMedID 40607589

  • Pathophysiology of intraoperative floppy iris syndrome: An unsettled debate. Survey of ophthalmology Shen, Y., Frauches, R., Zhao, J., Lo, C. H., Ning, K., Chen, S., Liu, Z., Zhang, F., Sun, Y. 2025

    Abstract

    Intraoperative floppy iris syndrome (IFIS)--characterized by iris blowing, prolapse, and progressive miosis during phacoemulsification surgery--poses significant challenges for eye surgeons. Despite being described almost 2 decades ago, its pathophysiology remains unclear. Initially, IFIS was thought to be a result of sympathetic signal blockage in the iris dilator muscle, since α-blockers such as tamsulosin were found to be a strong predisposing factor; however, many IFIS cases occur even in patients who discontinued α-blockers prior to cataract surgery. Several potential mechanisms through which α-blockers induces chronic changes in the iris - iris dilator atrophy, drug-melanin interaction, and loss of vascular tone - have been proposed as possible mechanisms. We address the prevailing theories on α-receptor-dependent mechanisms for IFIS and the current prophylactic measures undertaken to prevent IFIS-associated intraocular complications.

    View details for DOI 10.1016/j.survophthal.2025.06.002

    View details for PubMedID 40472999

  • Machine Learning Detection, Classification, and Quantification of Rosettes for Retinoblastoma Tumor Grading and Clinical Prognosis Mitsios, A., Nirschl, J., Frauches, R., Zuraski, C., Lin, J. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2025

    View details for Web of Science ID 001560059200045

  • Conjunctival blue nevus in a child - Case report and review of literature. American journal of ophthalmology case reports Yahya, Y., Nangia, P., Ahmad, H., Frauches, R. L., Lin, J. H., Mruthyunjaya, P. 2024; 36: 102151

    Abstract

    To report a rare case of a conjunctival blue nevus in a child.A 10-year-old girl underwent an excisional biopsy for an atypical growing melanocytic conjunctival lesion. The diagnosis of a conjunctival blue nevus was confirmed on histopathology. We describe the histopathology and the anterior segment optical coherence tomography features of a blue nevus in a 10-year-old child along with a review of literature.Conjunctival blue nevus is rare and has rarely been reported in a child. Multimodal imaging may help document lesion progression. This condition should remain in the differential for a growing, pigmented conjunctival lesion.

    View details for DOI 10.1016/j.ajoc.2024.102151

    View details for PubMedID 39282597

    View details for PubMedCentralID PMC11396036

  • Ocular Surface Fibroma of the Bulbar Conjunctiva. Ophthalmology Frauches, R., Lin, J. 2024

    View details for DOI 10.1016/j.ophtha.2024.05.008

    View details for PubMedID 38958614

  • Comparison of clinical slit lamp exam and specular microscopy vs histology on diagnosis of guttae Frauches, R., Lin, C., Egbert, P. R., Minckler, D., Lin, J. ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2024

    View details for Web of Science ID 001312227705321

  • Clinicopathologic Characterization of Guttae Containing and Non-Guttae Fuchs' Endothelial Dystrophy Frauches, R., Bharani, K., Egbert, P., Minckler, D., Lin, J. ELSEVIER SCIENCE INC. 2024: S1745

    View details for Web of Science ID 001302363406090