Professional Education

  • Doctor of Philosophy, University of Michigan Ann Arbor (2024)

Stanford Advisors

Contact

  • Academic
    rktan@stanford.edu
    University - Scholar Department: Cardiovascular Institute Operations Position: Postdoctoral Scholar

Additional Info

  • Mail Code: 5454

All Publications

  • Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients harbouring TTN mutations. Stem cell research Tan, R., Chen, Y. I., Zha, Y., Herron, T., Haddad, F., Sallam, K., Wu, J. C. 2025; 88: 103834

    Abstract

    Dilated cardiomyopathy (DCM) is a severe form of heart disease characterized by ventricular enlargement and impaired contractile function, often with a genetic basis. Truncating mutations in TTN, encoding the sarcomere protein titin, are one of the most common causes of DCM. To model titin-related DCM in vitro, we have established two human induced pluripotent stem cell (iPSC) lines from individuals who were diagnosed with DCM, each carrying a heterozygous truncating mutation within the TTN coding region. We have confirmed that both cell lines are normal in cell morphology, robustly express key pluripotency markers, maintain a normal diploid karyotype, and can differentiate into all three primary germ layers. These patient-specific iPSC lines represent an invaluable resource for investigating the complexity of titin-related cardiomyopathy.

    View details for DOI 10.1016/j.scr.2025.103834

    View details for PubMedID 40987017