All Publications

  • Recent Mechanistic Studies in Allergic Diseases. International journal of molecular sciences Sindher, S. B., Sharma, R., Yarlagadda, M., Chin, A. R., Chinthrajah, R. S. 2023; 24 (18)


    Allergic diseases, such as food allergies, asthma, and allergic rhinitis, continue to present a significant challenge for a broad cross-section of the population, despite recent advancements in their treatment and prevention [...].

    View details for DOI 10.3390/ijms241814312

    View details for PubMedID 37762615

    View details for PubMedCentralID PMC10531635

  • Peanut allergy: risk factors, immune mechanisms, and best practices for oral immunotherapy success. Expert review of clinical immunology Tirumalasetty, J., Barshow, S., Kost, L., Morales, L., Sharma, R., Lazarte, C., Nadeau, K. C. 2023: 1-11


    Peanut oral immunotherapy (pOIT) is the only FDA-approved treatment for food allergy and its adoption amongst allergist immunologists and their patients is growing. pOIT is the subject of numerous clinical trials, however, the focus is often on treatment efficacy, safety, and tolerability, rather than identifying patients most likely to benefit from pOIT. Here, we review existing data on the clinical and immunological outcomes of pOIT that inform best practices for pOIT candidate selection.In this review, we describe the natural history of peanut allergy, summarize immunological and clinical outcomes of pOIT at different ages, discuss the optimization of pOIT in key age groups, and finally suggest an ideal age range at which to initiate pOIT for best outcomes.pOIT is currently underutilized by patients and allergist-immunologists. Developing guidelines for selecting appropriate patients and optimizing treatment may help to increase access to pOIT. Many aspects of pOIT need additional study to further our understanding of the optimal timing to start pOIT, with careful consideration to clinical, immunological, and quality of life outcomes.

    View details for DOI 10.1080/1744666X.2023.2209318

    View details for PubMedID 37129440