Honors & Awards
Fellow, Summer Opportunities in Engineering Research and Leadership, Stanford University (2023)
Tau Beta Pi Fellowship, The Engineering Honor Society (2023-2024)
Graduate Research Fellowship Program, National Science Foundation (2023-2027)
Graduate Fellowship in Science & Engineering, Stanford University (2023-2028)
Education & Certifications
BS, Cornell University, Mechanical Engineering, Biological Engineering (2023)
Novel requirements for HAP2-mediated gamete fusion in Tetrahymena.
The ancestral gamete fusion protein, HAP2/GCS1 catalyzes sperm-egg fusion in a broad range of taxa dating to the last eukaryotic common ancestor. Remarkably, HAP2/GCS1 orthologs are structurally related to the class II fusogens of modern-day viruses, and recent studies make clear that these proteins utilize similar mechanisms to achieve membrane merger. To identify factors that may regulate HAP2/GCS1 activity, we screened mutants of the ciliate Tetrahymena thermophila for behaviors that mimic Δhap2/gcs1 knockout phenotypes in this species. Using this approach, we identified two new genes, GFU1 and GFU2, whose products are necessary for the formation of membrane pores during fertilization and show that the product of a third gene, namely ZFR1, may be involved in pore maintenance and/or expansion. Finally, we propose a model that explains cooperativity between the fusion machinery on apposed membranes of mating cells and accounts for successful fertilization in T. thermophila's multiple mating type system.
View details for DOI 10.21203/rs.3.rs-2928984/v1
View details for PubMedID 37292678
View details for PubMedCentralID PMC10246275
- MRTF may be the missing link in a multiscale mechanobiology approach toward macrophage dysfunction in space FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2022; 10
- CAMDLES: CFD-DEM Simulation of Microbial Communities in Spaceflight and Artificial Microgravity LIFE-BASEL 2022; 12 (5)