Contact

  • Academic
    saumilp@stanford.edu
    University - Academic staff Department: Ophthalmology Research/Clinical Trials Position: Sr Res Scientist-Basic Life

Additional Info

  • Mail Code: 5353

All Publications

  • Playing three-dimensional video games boosts stereo vision. Current biology : CB Li, R. W., Li, B. Z., Chat, S. W., Patel, S. S., Chung, S. T., Levi, D. M. 2024; 34 (11): R524-R525

    Abstract

    Playing two-dimensional video games has been shown to result in improvements in a range of visual and cognitive tasks, and these improvements appear to generalize widely1,2,3,4,5,6. Here we report that young adults with healthy vision, surprisingly, showed a dramatic improvement in stereo vision after playing three-dimensional, but not two-dimensional, video games for a relatively short period of time. Intriguingly, neither group showed any significant improvement in binocular contrast sensitivity. This dissociation suggests that the visual enhancement was specific to genuine stereoscopic processing, not indirectly resulting from enhanced contrast processing, and required engaging in a disparity cue-rich three-dimensional environment.

    View details for DOI 10.1016/j.cub.2024.04.032

    View details for PubMedID 38834021

  • Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy. Cell Liu, Z., Lu, X., Villette, V., Gou, Y., Colbert, K. L., Lai, S., Guan, S., Land, M. A., Lee, J., Assefa, T., Zollinger, D. R., Korympidou, M. M., Vlasits, A. L., Pang, M. M., Su, S., Cai, C., Froudarakis, E., Zhou, N., Patel, S. S., Smith, C. L., Ayon, A., Bizouard, P., Bradley, J., Franke, K., Clandinin, T. R., Giovannucci, A., Tolias, A. S., Reimer, J., Dieudonne, S., St-Pierre, F. 2022

    Abstract

    Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics with cell-type specificity. However, current indicators enable a narrow range of applications due to poor performance under two-photon microscopy, a method of choice for deep-tissue recording. To improve indicators, we developed a multiparameter high-throughput platform to optimize voltage indicators for two-photon microscopy. Using this system, we identified JEDI-2P, an indicator that is faster, brighter, and more sensitive and photostable than its predecessors. We demonstrate that JEDI-2P can report light-evoked responses in axonal termini of Drosophila interneurons and the dendrites and somata of amacrine cells of isolated mouse retina. JEDI-2P can also optically record the voltage dynamics of individual cortical neurons in awake behaving mice for more than 30min using both resonant-scanning and ULoVE random-access microscopy. Finally, ULoVE recording of JEDI-2P can robustly detect spikes at depths exceeding 400mum and report voltage correlations in pairs of neurons.

    View details for DOI 10.1016/j.cell.2022.07.013

    View details for PubMedID 35985322