Dr. Schmiedmayer is the Assistant Director Digital Health and postdoctoral researcher at the Byers Center for Biodesign at Stanford University, focusing on the applications of computer science innovations in medicine. He focuses on digital health solutions, including AI-driven systems and healthcare interoperability. He is leading the development of the Stanford Spezi framework and ecosystem.

He earned his doctoral degree at the Technical University of Munich, where he studied software engineering, mobile-based systems including smart devices, the applications and integration of machine learning techniques, and the evolution of web service-based distributed systems. He holds a master's and bachelor's degree in computer science from the Technical University of Munich.

Current Research and Scholarly Interests

Paul Schmiedmayer's research applies computer science research to medicine, enabling digital health innovations. These include machine learning applications and deployments, heterogeneous connected devices, health data standards such as FHIR, and software engineering best practices.
He leads the development of the Stanford Spezi framework and ecosystem, enabling the rapid development of digital health innovations. He is a co-instructor of the Building for Digital Health (CS342) course.

Lab Affiliations

All Publications

  • Quantitative DigitoGraphy: a Comprehensive Real-Time Remote Monitoring System for Parkinson's Disease. Research square Hoffman, S. L., Schmiedmayer, P., Gala, A. S., Wilkins, K. B., Parisi, L., Karjagi, S., Negi, A. S., Revlock, S., Coriz, C., Revlock, J., Ravi, V., Bronte-Stewart, H. 2024


    People with Parkinson's disease (PWP) face critical challenges, including lack of access to neurological care, inadequate measurement and communication of motor symptoms, and suboptimal medication management and compliance. We have developed QDG-Care: a comprehensive connected care platform for Parkinson's disease (PD) that delivers validated, quantitative metrics of all motor signs in PD in real time, monitors the effects of adjusting therapy and medication adherence and is accessible in the electronic health record. In this article, we describe the design and engineering of all components of QDG-Care, including the development and utility of the QDG Mobility and Tremor Severity Scores. We present the preliminary results and insights from the first at-home trial using QDG-Care. QDG technology has enormous potential to improve access to, equity of, and quality of care for PWP, and improve compliance with complex time-critical medication regimens. It will enable rapid "Go-NoGo" decisions for new therapeutics by providing high-resolution data that require fewer participants at lower cost and allow more diverse recruitment.

    View details for DOI 10.21203/

    View details for PubMedID 38343821

    View details for PubMedCentralID PMC10854288

  • Utility of smart watches for identifying arrhythmias in children. Communications medicine Zahedivash, A., Chubb, H., Giacone, H., Boramanand, N. K., Dubin, A. M., Trela, A., Lencioni, E., Motonaga, K. S., Goodyer, W., Navarre, B., Ravi, V., Schmiedmayer, P., Bikia, V., Aalami, O., Ling, X. B., Perez, M., Ceresnak, S. R. 2023; 3 (1): 167


    Arrhythmia symptoms are frequent complaints in children and often require a pediatric cardiology evaluation. Data regarding the clinical utility of wearable technologies are limited in children. We hypothesize that an Apple Watch can capture arrhythmias in children.We present an analysis of patients ≤18 years-of-age who had signs of an arrhythmia documented by an Apple Watch. We include patients evaluated at our center over a 4-year-period and highlight those receiving a formal arrhythmia diagnosis. We evaluate the role of the Apple Watch in arrhythmia diagnosis, the results of other ambulatory cardiac monitoring studies, and findings of any EP studies.We identify 145 electronic-medical-record identifications of Apple Watch, and find arrhythmias confirmed in 41 patients (28%) [mean age 13.8 ± 3.2 years]. The arrythmias include: 36 SVT (88%), 3 VT (7%), 1 heart block (2.5%) and wide 1 complex tachycardia (2.5%). We show that invasive EP study confirmed diagnosis in 34 of the 36 patients (94%) with SVT (2 non-inducible). We find that the Apple Watch helped prompt a workup resulting in a new arrhythmia diagnosis for 29 patients (71%). We note traditional ambulatory cardiac monitors were worn by 35 patients (85%), which did not detect arrhythmias in 10 patients (29%). In 73 patients who used an Apple Watch for recreational or self-directed heart rate monitoring, 18 (25%) sought care due to device findings without any arrhythmias identified.We demonstrate that the Apple Watch can record arrhythmia events in children, including events not identified on traditionally used ambulatory monitors.

    View details for DOI 10.1038/s43856-023-00392-9

    View details for PubMedID 38092993

    View details for PubMedCentralID 4937287

  • CardinalKit: open-source standards-based, interoperable mobile development platform to help translate the promise of digital health. JAMIA open Aalami, O., Hittle, M., Ravi, V., Griffin, A., Schmiedmayer, P., Shenoy, V., Gutierrez, S., Venook, R. 2023; 6 (3): ooad044


    Smartphone devices capable of monitoring users' health, physiology, activity, and environment revolutionize care delivery, medical research, and remote patient monitoring. Such devices, laden with clinical-grade sensors and cloud connectivity, allow clinicians, researchers, and patients to monitor health longitudinally, passively, and persistently, shifting the paradigm of care and research from low-resolution, intermittent, and discrete to one of persistent, continuous, and high resolution. The collection, transmission, and storage of sensitive health data using mobile devices presents unique challenges that serve as significant barriers to entry for care providers and researchers alike. Compliance with standards like HIPAA and GDPR requires unique skills and practices. These requirements make off-the-shelf technologies insufficient for use in the digital health space. As a result, budget, timeline, talent, and resource constraints are the largest barriers to new digital technologies. The CardinalKit platform is an open-source project addressing these challenges by focusing on reducing these barriers and accelerating the innovation, adoption, and use of digital health technologies. CardinalKit provides a mobile template application and web dashboard to enable an interoperable foundation for developing digital health applications. We demonstrate the applicability of CardinalKit to a wide variety of digital health applications across 18 innovative digital health prototypes.

    View details for DOI 10.1093/jamiaopen/ooad044

    View details for PubMedID 37485467

    View details for PubMedCentralID PMC10356573

  • Reducing the Impact of Breaking Changes to Web Service Clients During Web API Evolution Schmiedmayer, P., Bauer, A., Bruegge, B., IEEE IEEE COMPUTER SOC. 2023: 1-11
  • Global Software Engineering in a Global Classroom Schmiedmayer, P., Chatley, R., Bernius, J., Krusche, S., Chaika, K., Krinkin, K., Bruegge, B., IEEE Comp Soc IEEE COMPUTER SOC. 2022: 113-121