Shaya Alimoghadam

All Publications

• The frequency of AmpC overproduction, OprD downregulation and OprM efflux pump expression in Pseudomonas aeruginosa: A comprehensive meta-analysis. Journal of global antimicrobial resistance Alimoghadam, S., Eslami, A., Alimoghadam, R., Bahrami Mianrood, I., Azizmohammad Looha, M., Khodadadi, S., Shokouhi, S., Alavi Darazam, I. 2024; 39: 159-169

  Abstract

  Pseudomonas aeruginosa is a major opportunistic pathogen responsible for a wide range of infections. The emergence of antibiotic resistance in this pathogen poses a significant public health challenge. This study aims to conduct a comprehensive meta-analysis of studies conducted in Iran to determine the frequency of key antibiotic resistance mechanisms in Pseudomonas aeruginosa and their association with multidrug-resistant and extensively drug-resistant strains or pandrug-resistant strains.Systematic database searches encompassing literature up to June 2023 were undertaken. The selected studies centered on OprD downregulation, efflux pump (mexAB-OprM, mexXY-OprM) expression, and AmpC overproduction. Extracted data were synthesised in a meta-analysis for pooled frequency determination of each resistance mechanism.In total, 24 studies were included. OprD downregulation exhibited a pooled frequency of 61%. Efflux pump component frequency ranged from 48% to 77.5%. AmpC overproduction was identified in 29.1% of isolates. Polymyxin B and colistin demonstrated lower antibiotic resistance rates, with pooled frequency of 1% and 1.6%, respectively. Conversely, resistance to other antibiotics ranged widely, with pooled frequency spanning 38.4% to 98.2%.This study underscores the concerning frequency of diverse antibiotic resistance mechanisms in Pseudomonas aeruginosa strains from Iran. Concurrent OprD downregulation, mexAB, mexXY, OprM expression, and AmpC overproduction highlight the urgent need for stringent infection control and prudent antibiotic usage to curb the dissemination of these resistant strains.CRD42022379311.

  View details for DOI 10.1016/j.jgar.2024.08.014

  View details for PubMedID 39303871

• Comprehensive insights into tuberculosis-associated hemophagocytic lymphohistiocytosis: a systematic review. BMC infectious diseases Eslami, A., Alimoghadam, S., Khodadadi, S., Allahverdi, H., Alimoghadam, R., Kasaeian, A., Mansouri, D., Alimoghaddam, K., Alavi Darazam, I. 2024; 24 (1): 1341

  Abstract

  Tuberculosis-associated hemophagocytic lymphohistiocytosis (TB-HLH) presents significant challenges in diagnosis and treatment due to its complex interplay between TB and HLH. This systematic review aims to provide comprehensive insights into the epidemiology, clinical characteristics, and treatment outcomes of TB-HLH patients.We performed a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Scopus, Web of Science, and Embase up to May 16, 2023, without language restrictions. We included case reports and cases series on patients with both TB and HLH with documented treatment outcomes. Data were analyzed using descriptive statistics, chi-square or Fisher's exact tests, t-tests, and mortality rates. Significant variables (p < 0.05) from univariate analysis and clinically relevant factors were used in binary logistic regression to determine odds ratios, 95% confidence intervals, and p-values.A total of 185 articles involving 213 patients were included. The overall mortality rate was 39%. Age ≥ 44 years and comorbidities were identified as independent risk factors for increased mortality (p = 0.005). Anti-tuberculosis treatment (ATT) combined with HLH-specific therapies, was associated with reduced mortality compared to ATT alone (p < 0.05), especially IVIG (p = 0.04).Integrating ATT with HLH-specific therapies significantly enhances survival in TB-HLH patients. Additionally, IVIG plays a key role in improving outcomes. Age ≥ 44 years and comorbidities are critical risk factors for increased mortality. Early and high suspicion of TB-HLH is essential, especially in high TB burden regions or recent travel contexts. Future research should focus on prospective multicenter studies to validate our findings and develop standardized treatment strategies on TB-HLH.CRD42022364180.

  View details for DOI 10.1186/s12879-024-10220-7

  View details for PubMedID 39581974

  View details for PubMedCentralID PMC11587777

• Mpox vaccination and treatment: a systematic review. Journal of chemotherapy (Florence, Italy) Eslami, A., Alimoghadam, S., Khoshravesh, S., Shirani, M., Alimoghadam, R., Alavi Darazam, I. 2024; 36 (2): 85-109

  Abstract

  The Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, Scopus, Web of Science, Cochrane Library, and Clinicaltrials.gov, reviewing 69 relevant articles from 4,342 screened records. Our analysis highlights Modified Vaccinia Ankara - Bavarian Nordic (MVA-BN)'s potential, though efficacy concerns exist. Tecovirimat emerged as a prominent antiviral in the recent outbreak. However, limited evidence underscores the imperative for further clinical trials in understanding and managing monkeypox.

  View details for DOI 10.1080/1120009X.2023.2289270

  View details for PubMedID 38069596

• Systematic review of radiocarpal dislocations: epidemiology, treatment modalities, and outcomes. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Eslami, A., Torkaman, A., Alimoghadam, S., Pisoudeh, K., Ebrahimzadeh Babaki, A., Ghaeini, M., Torkaman, P., Elahifar, O., Dehghani Nazhvani, H. 2025; 35 (1): 132

  Abstract

  Radiocarpal dislocation (RCD) is a rare but severe injury, often resulting from high-energy trauma such as motor vehicle accidents and falls. This study aims to synthesize existing case reports and series to provide insights into the epidemiology, associated injuries, and management strategies for RCD.A systematic search of PubMed, Scopus, and Web of Science was conducted, including English-language case reports and series up to August 5, 2023. Data extraction followed PRISMA guidelines, with bias assessment using Joanna Briggs Institute criteria. Descriptive statistics and t tests were applied to analyze demographics, treatments, and outcomes.Among 343 articles, 57 met inclusion criteria, covering 303 patients. The mean age was 36.52 years, with males comprising 78.9%. Dorsal dislocations were the most common type. Fractures, particularly of the radial styloid, were present in most cases. Common soft tissue injuries included median nerve compression, TFCC/DRUJ injuries, and scapholunate ligament tears. Ligament repair, performed in 24.7% of cases, improved flexion-extension outcomes (p = 0.048) but showed no significant effects on ulnar or radial deviation. Spanning plates demonstrated acceptable outcomes in one study.RCDs are complex injuries requiring comprehensive diagnostic assessment and tailored treatment strategies, particularly addressing associated fractures and soft tissue damage. While ligament repair may enhance flexion-extension, its role in overall joint stability remains uncertain. Further prospective, multicenter studies are needed to better evaluate treatment approaches, including the effectiveness of ligament repair, and to refine management protocols for improved long-term patient outcomes.

  View details for DOI 10.1007/s00590-025-04252-1

  View details for PubMedID 40137999

  View details for PubMedCentralID 8982567

• Traumatic pelvic ring fracture during pregnancy: a systematic review. EFORT open reviews Eslami, A., Chehrassan, M., Alimoghadam, S., Pisoudeh, K., Kasaeian, A., Elahifar, O. 2024; 9 (7): 700-711

  Abstract

  This systematic review aims to investigate the management and outcomes of pelvic ring fractures (PRFs) during pregnancy, emphasizing maternal and fetal mortality rates, mechanisms of injury, and treatment modalities.Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive search of databases from 2000 to 2023, identifying 33 relevant studies. Data extraction included demographics, fracture types, treatment methods, and outcomes. Risk of bias was assessed using the JBI criteria.Maternal mortality stood at 9.1%, with fetal mortality at 42.4%. Maternal factors impacting mortality included head trauma and hemodynamic instability. Fetal mortality correlated with mechanisms like motor vehicle accidents and maternal vital signs. Surgical and conservative treatments were applied, with a majority of pelvic surgeries performed before delivery. External fixators proved effective in fracture stabilization.Pelvic ring fractures during pregnancy present significant risks to maternal and fetal health. Early stabilization and vigilant monitoring of maternal vital signs are crucial. Vaginal bleeding/discharge serves as a critical fetal risk indicator. The choice between surgical and conservative treatment minimally influenced outcomes. Multidisciplinary collaboration and tailored interventions are essential in managing these complex cases.

  View details for DOI 10.1530/EOR-23-0164

  View details for PubMedID 38949162

  View details for PubMedCentralID PMC11297399

• Aspirin is as effective as low molecular weight heparins in preventing symptomatic venous thromboembolism following arthroscopic anterior cruciate ligament reconstruction. BMC musculoskeletal disorders Yazdi, H., Eslami, A., Torkaman, A., Elahifar, O., Kasaeian, A., Alimoghadam, S., Alimoghadam, R., Abolghasemian, M. 2024; 25 (1): 154

  Abstract

  The optimal agent for thromboprophylaxis following arthroscopic anterior cruciate ligament reconstruction (ACLR) remains unclear, particularly in patients with a low baseline risk for venous thromboembolism (VTE). This retrospective cohort study aims to compare the effectiveness and safety of aspirin versus low molecular weight heparins (LMWHs) in this specific patient population.We analyzed data from patients who underwent ACLR between March 2016 and March 2021, focusing on those with a low risk for VTE. High-risk individuals, identified by factors such as cardiac disease, pulmonary disease, diabetes mellitus, previous VTE, inflammatory bowel disease, active cancer, and a BMI > 40, were excluded (n = 33). Our approach included a thorough review of medical charts, surgical reports, and pre-operative assessments, complemented by telephone follow-up conducted over a 3-month period by a single investigator. We assessed the incidence of symptomatic VTE, including deep vein thrombosis and pulmonary thromboembolism, as the primary outcome. The secondary outcomes included to complications related to the surgery and thromboprophylaxis. Statistical analysis included descriptive statistics, univariate logistic regression models, and calculations of incidence rates.In our study, 761 patients (761 knees) were included, with 458 (60.18%) receiving aspirin and 303 (39.82%) receiving LMWH. The two groups showed no significant differences in demographic factors except for age. The incidence of VTE was reported at 1.31% (10 individuals). Specifically, five patients in the aspirin group (1.09%) and five patients in the LMWH group (1.65%) developed a symptomatic VTE event (p = 0.53). Additionally, the two groups did not significantly differ in terms of other complications, such as hemarthrosis or surgical site infection (p > 0.05). Logistic regression analysis revealed no statistically significant difference in VTE risk between the two groups.This study, focusing on isolated ACLR in patients with a low baseline risk for venous thromboembolism, demonstrated that aspirin is equally effective as low molecular weight heparins for VTE prophylaxis following this surgery.III.

  View details for DOI 10.1186/s12891-024-07282-8

  View details for PubMedID 38373950

  View details for PubMedCentralID PMC10875785

• Reply - Letter to the Editor: Trans-Table Intraoperative Fluoroscopic Technique for Obtaining a True Lateral View of the Proximal Femur in the Lateral Decubitus Position Response ARCHIVES OF BONE AND JOINT SURGERY-ABJS Eslami, A. 2023; 11 (12): 794-795

  View details for DOI 10.22038/ABJS.2023.73085.3386

  View details for Web of Science ID 001129906200002

• Congenital lumbosacral junction kyphosis in an adult patient: A case report. Clinical case reports Eslami, A., Chehrassan, M., Alimoghadam, S., Shakeri, M. 2023; 11 (10): e8094

  Abstract

  Rare lumbosacral junction kyphosis due to S1-S2 hemivertebra in a 40-year-old woman was managed surgically, improving neurological disturbances, and low back pain. Early intervention is vital for congenital anomalies.

  View details for DOI 10.1002/ccr3.8094

  View details for PubMedID 37881197

  View details for PubMedCentralID PMC10593970

• External Fixator as a Viable Treatment Option for Combined Pelvic Ring and Sacrum Fracture in a Pregnant Patient: A Case Report. The archives of bone and joint surgery Pisoudeh, K., Alimoghadam, S., Elahifar, O., Eslami, A. 2023; 11 (7): 476-480

  Abstract

  We report a case of a 32-year-old pregnant woman who suffered a combined type pelvic fracture and medial malleolus fracture due to a car accident at 24 weeks and 2 days of gestation. She underwent external fixation of the pelvic ring and percutaneous screw fixation of the ankle fracture. She recovered well and delivered a healthy baby by cesarean section at 37 weeks and 1-day gestation. External fixation can be a definitive treatment option for some pelvic fractures with anterior instability in pregnant patients, as it reduces the risk of fetal harm.

  View details for DOI 10.22038/ABJS.2023.71908.3355

  View details for PubMedID 37538134

  View details for PubMedCentralID PMC10394743

• Transabdominal Ultrasound Measurement of the Diameter of Rectal Ampulla as a Less Invasive Modality for Digital Rectal Examination in Children with Functional Constipation IRANIAN JOURNAL OF PEDIATRICS Imanzadeh, F., Hosseini, A., Khalili, M., Naghdi, E., Hajipour, M., Yazdanifard, P., Alimoghadam, S., Fateh, S., Aminzade, Z., Mohseni, P., Fasihi, M., Safari, T. 2022; 32 (5)

  View details for DOI 10.5812/ijp-114354

  View details for Web of Science ID 000854385200002