Honors & Awards

  • Provost's Honors, University of California at San Diego (2019-2022)
  • Highest Departmental Distinction and Honors, University of California at San Diego (2021)
  • Harold C. Urey Award, University of California at San Diego (2021)

Education & Certifications

  • M.Sc., University of California, San Diego, Chemistry: Chemical Biology (2022)
  • B.Sc., University of California, San Diego, Biochemistry (Summa cum laude, Highest Distinction, and Departmental Honors) (2021)

All Publications

  • Cerebellar Granule Cells Develop Non-neuronal 3D Genome Architecture over the Lifespan. bioRxiv : the preprint server for biology Tan, L., Shi, J., Moghadami, S., Wright, C. P., Parasar, B., Seo, Y., Vallejo, K., Cobos, I., Duncan, L., Chen, R., Deisseroth, K. 2023


    The cerebellum contains most of the neurons in the human brain, and exhibits unique modes of development, malformation, and aging. For example, granule cells-the most abundant neuron type-develop unusually late and exhibit unique nuclear morphology. Here, by developing our high-resolution single-cell 3D genome assay Dip-C into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we were able to resolve the first 3D genome structures of single cerebellar cells, create life-spanning 3D genome atlases for both human and mouse, and jointly measure transcriptome and chromatin accessibility during development. We found that while the transcriptome and chromatin accessibility of human granule cells exhibit a characteristic maturation pattern within the first year of postnatal life, 3D genome architecture gradually remodels throughout life into a non-neuronal state with ultra-long-range intra-chromosomal contacts and specific inter-chromosomal contacts. This 3D genome remodeling is conserved in mice, and robust to heterozygous deletion of chromatin remodeling disease-associated genes ( Chd8 or Arid1b ). Together these results reveal unexpected and evolutionarily-conserved molecular processes underlying the unique development and aging of the mammalian cerebellum.

    View details for DOI 10.1101/2023.02.25.530020

    View details for PubMedID 36865235

  • Mannose-Binding Lectin is Dysregulated in Cardiac Endothelial Cells of Women With Peripartum Cardiomyopathy Aryan, Z., Moghadami, S., Wang, W., Sadoshima, J. LIPPINCOTT WILLIAMS & WILKINS. 2022