Sina Sadeghzadeh

All Publications

• Implications of Frailty on Post-Operative Healthcare Resource Utilization in Ankylosing Spondylitis Patients Undergoing Spine Surgery for Spinal Fractures. World neurosurgery Elsamadicy, A. A., Sayeed, S., Sadeghzadeh, S., Reeves, B. C., Sherman, J. J., Craft, S., Serrato, P., Larry Lo, S., Sciubba, D. M. 2023

  Abstract

  OBJECTIVE: The rise of spinal surgery for Ankylosing Spondylitis (AS) necessitates balancing healthcare costs with quality patient care. Frailty has been independently associated with adverse outcomes and increased costs. This study investigates whether frailty is an independent predictor of poor outcomes after elective surgery for AS.METHODS: Using the National Inpatient Sample (NIS) database, a retrospective study was conducted on adult patients with AS who underwent posterior spinal fusion for fracture between 2016-2019. Each patient was assigned a modified frailty index (mFI) score and categorized as pre-frail (mFI=0 or 1), moderately frail (mFI=2), highly frail (mFI≥3). Multivariate logistic regression analyses were used to identify independent predictors of extended length of stay (LOS), non-routine discharge (NRD), and exorbitant admission costs.RESULTS: Of the 1,910 patients, 35.3% were pre-frail, 31.2% moderately frail, and 33.5% highly frail. Age was significantly different across groups (p<0.001), and frailty was associated with increased comorbidities (p<0.001). Mean LOS (p=0.007), non-routine discharge rate (p<0.001), and mean cost of admission (p=0.002) all significantly increased with increasing frailty. However, frailty was not an independent predictor of extended hospital stay, non-routine discharge, or higher costs on multivariate analysis. Instead, predictors included multiple adverse events, number of comorbidities, and race.CONCLUSION: S: While frailty in patients with AS is associated with older age, greater comorbidities, and increased adverse events, it was not an independent predictor of extended hospital stay, non-routine discharge, or higher hospital costs. Further research is required to understand the full impact of frailty on surgical outcomes and develop effective interventions.

  View details for DOI 10.1016/j.wneu.2023.10.136

  View details for PubMedID 37925147

• Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms NEURON Chung, H., Wangler, M. F., Marcogliese, P. C., Jo, J., Ravenscroft, T. A., Zuo, Z., Duraine, L., Sadeghzadeh, S., Li-Kroeger, D., Schmidt, R. E., Pestronk, A., Rosenfeld, J. A., Burrage, L., Herndon, M. J., Chen, S., Shillington, A., Vawter-Lee, M., Hopkin, R., Rodriguez-Smith, J., Henrickson, M., Lee, B., Moser, A. B., Jones, R. O., Watkins, P., Yoo, T., Mar, S., Choi, M., Bucelli, R. C., Yamamoto, S., Lee, H., Prada, C. E., Chae, J., Vogel, T. P., Bellen, H. J., Undiagnosed Dis Network 2020; 106 (4): 589-+

  Abstract

  ACOX1 (acyl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the very-long-chain fatty acid (VLCFA) β-oxidation pathway in peroxisomes and leads to H2O2 production. Unexpectedly, Drosophila (d) ACOX1 is mostly expressed and required in glia, and loss of ACOX1 leads to developmental delay, pupal death, reduced lifespan, impaired synaptic transmission, and glial and axonal loss. Patients who carry a previously unidentified, de novo, dominant variant in ACOX1 (p.N237S) also exhibit glial loss. However, this mutation causes increased levels of ACOX1 protein and function resulting in elevated levels of reactive oxygen species in glia in flies and murine Schwann cells. ACOX1 (p.N237S) patients exhibit a severe loss of Schwann cells and neurons. However, treatment of flies and primary Schwann cells with an antioxidant suppressed the p.N237S-induced neurodegeneration. In summary, both loss and gain of ACOX1 lead to glial and neuronal loss, but different mechanisms are at play and require different treatments.

  View details for DOI 10.1016/j.neuron.2020.02.021

  View details for Web of Science ID 000535696300009

  View details for PubMedID 32169171

  View details for PubMedCentralID PMC7289150

• The relation between pica and iron deficiency in children in Zanjan, Islamic Republic of Iran: a case-control study EASTERN MEDITERRANEAN HEALTH JOURNAL Sadeghzadeh, M., Khoshnevisasl, P., Sadeghzadeh, S. 2017; 23 (6): 404-407

  Abstract

  The aim of this case-control study was to determine the frequency of pica and its relationship with iron deficiency in children in Zanjan. We selected 872 children and determined the frequency of pica. We selected students who did not have pica of the same age and sex, and in the same class as our cases as a control group. Both groups were evaluated for iron deficiency anaemia. Among the 57 students (6.7%) who had pica, there was no significant relationship with sex (P > 0.05). The most common types of pica were soil (62.3%) and paper (31.2%). The frequency of anaemia among cases was greater than in controls, although the difference was not statistically significant. The serum iron/total iron binding capacity ratio ≤ 0.15 did not differ significantly between the 2 groups. We did not find any association between pica and anaemia and/or iron deficiency (P > 0.05).

  View details for Web of Science ID 000410076000003

  View details for PubMedID 28836652