All Publications

  • Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil. Science advances Giovanetti, M., Pinotti, F., Zanluca, C., Fonseca, V., Nakase, T., Koishi, A. C., Tscha, M., Soares, G., Dorl, G. G., Marques, A. E., Sousa, R., Adelino, T. E., Xavier, J., de Oliveira, C., Patroca, S., Guimaraes, N. R., Fritsch, H., Mares-Guia, M. A., Levy, F., Passos, P. H., da Silva, V. L., Pereira, L. A., Mendonça, A. F., de Macêdo, I. L., Ribeiro de Sousa, D. E., Rodrigues de Toledo Costa, G., Botelho de Castro, M., de Souza Andrade, M., de Abreu, F. V., Campos, F. S., Iani, F. e., Pereira, M. A., Cavalcante, K. R., de Freitas, A. R., Campelo de Albuquerque, C. F., Macário, E. M., Dos Anjos, M. P., Ramos, R. C., Campos, A. A., Pinter, A., Chame, M., Abdalla, L., Riediger, I. N., Ribeiro, S. P., Bento, A. I., de Oliveira, T., Freitas, C., Oliveira de Moura, N. F., Fabri, A., Dos Santos Rodrigues, C. D., Dos Santos, C. C., Barreto de Almeida, M. A., Dos Santos, E., Cardoso, J., Augusto, D. A., Krempser, E., Mucci, L. F., Gatti, R. R., Cardoso, S. F., Fuck, J. A., Lopes, M. G., Belmonte, I. L., Mayoral Pedroso da Silva, G., Soares, M. R., de Castilhos, M. d., de Souza E Silva, J. C., Bisetto Junior, A., Pouzato, E. G., Tanabe, L. S., Arita, D. A., Matsuo, R., Dos Santos Raymundo, J., Silva, P. C., Santana Araújo Ferreira Silva, A., Samila, S., Carvalho, G., Stabeli, R., Navegantes, W., Moreira, L. A., Ferreira, A. G., Pinheiro, G. G., Nunes, B. T., de Almeida Medeiros, D. B., Cruz, A. C., Venâncio da Cunha, R., Van Voorhis, W., Bispo de Filippis, A. M., Almiron, M., Holmes, E. C., Ramos, D. G., Romano, A., Lourenço, J., Alcantara, L. C., Duarte Dos Santos, C. N. 2023; 9 (35): eadg9204


    Despite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centers in the Southeast. Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.

    View details for DOI 10.1126/sciadv.adg9204

    View details for PubMedID 37656782

  • Global transmission suitability maps for dengue virus transmitted by Aedes aegypti from 1981 to 2019. Scientific data Nakase, T., Giovanetti, M., Obolski, U., Lourenco, J. 2023; 10 (1): 275


    Mosquito-borne viruses increasingly threaten human populations due to accelerating changes in climate, human and mosquito migration, and land use practices. Over the last three decades, the global distribution of dengue has rapidly expanded, causing detrimental health and economic problems in many areas of the world. To develop effective disease control measures and plan for future epidemics, there is an urgent need to map the current and future transmission potential of dengue across both endemic and emerging areas. Expanding and applying Index P, a previously developed mosquito-borne viral suitability measure, we map the global climate-driven transmission potential of dengue virus transmitted by Aedes aegypti mosquitoes from 1981 to 2019. This database of dengue transmission suitability maps and an R package for Index P estimations are offered to the public health community as resources towards the identification of past, current and future transmission hotspots. These resources and the studies they facilitate can contribute to the planning of disease control and prevention strategies, especially in areas where surveillance is unreliable or non-existent.

    View details for DOI 10.1038/s41597-023-02170-7

    View details for PubMedID 37173303

  • Letter to the editor: Atypical weather is associated with the 2022 early start of West Nile virus transmission in Italy EUROSURVEILLANCE Lourenco, J., Pinotti, F., Nakase, T., Giovanetti, M., Obolski, U. 2022; 27 (34)