Bio


Talal Seddik is a Clinical Assistant Professor of Pediatric Infectious Diseases. His main research interest is in determining risk factors for bloodstream infection in children who have intestinal insufficiency.

Clinical Focus


  • Pediatric Infectious Diseases

Academic Appointments


Professional Education


  • Board Certification: American Board of Pediatrics, Pediatric Infectious Diseases (2019)
  • Fellowship: Stanford University Pediatric Infectious Disease Fellowship (2018) CA
  • Board Certification: American Board of Pediatrics, Pediatrics (2015)
  • Residency: University of Florida at Sacred Heart Pediatric Residency (2015) FL
  • Medical Education: Cairo University Faculty of Medicine Office of the Registrar (2009) Egypt
  • Board Certification, American Board of Pediatrics (2015)
  • Residency, Florida State University (2015)
  • Internship, Florida State University (2013)
  • Medical Education, Cairo University School of Medicine (2009)

Current Research and Scholarly Interests


- Epidemiology, microbiology and outcomes of bloodstream infection in children with intestinal insufficiency requiring parenteral nutrition

- The utility of cell-free next generation DNA sequencing for the diagnosis of infectious diseases

All Publications


  • Reducing Piperacillin and Tazobactam Use for Pediatric Perforated Appendicitis. The Journal of surgical research Seddik, T. B., Rabsatt, L. A., Mueller, C. n., Bassett, H. K., Contopoulos-Ioannidis, D. n., Bio, L. L., Anderson, V. D., Schwenk, H. T. 2020; 260: 141–48

    Abstract

    Although perforated appendicitis is associated with infectious complications, the choice of antibiotic therapy is controversial. We assess the effectiveness and safety of an intervention to reduce piperacillin and tazobactam (PT) use for pediatric acute perforated appendicitis.This is a single-center, retrospective cohort study of children 18 y of age who underwent primary appendectomy for perforated appendicitis between January 01, 2016 and June 30, 2019. An intervention to decrease PT use was implemented: the first phase was provider education (April 19, 2017) and the second phase was modification of electronic antibiotic orders to default to ceftriaxone and metronidazole (July 06, 2017). Preintervention and postintervention PT exposure, use of PT ≥ half of intravenous antibiotic days, and clinical outcomes were compared.Forty children before and 109 after intervention were included and had similar baseline characteristics. PT exposure was 31 of 40 (78%) and 20 of 109 (18%) (P < 0.001), and use ≥ half of intravenous antibiotic days was 31 of 40 (78%) and 14 of 109 (13%) (P < 0.001), in the preintervention and postintervention groups, respectively. There was no significant difference in mean duration of antibiotic therapy (10.8 versus 9.8 d), mean length of stay (6.2 versus 6.5 d), rate of surgical site infection (10% versus 11%), or rate of 30-d readmission and emergency department visit (20% versus 20%) between the preintervention and postintervention periods, respectively.Provider education and modification of electronic antibiotic orders safely reduced the use of PT for pediatric perforated appendicitis.

    View details for DOI 10.1016/j.jss.2020.11.067

    View details for PubMedID 33340867

  • Risk Factors of Ambulatory Central Line-Associated Bloodstream Infection in Pediatric Short Bowel Syndrome. JPEN. Journal of parenteral and enteral nutrition Seddik, T. B., Tian, L., Nespor, C., Kerner, J., Maldonado, Y., Gans, H. 2019

    Abstract

    BACKGROUND: Children with short bowel syndrome (SBS) receiving home parenteral nutrition (HPN) are predisposed to ambulatory central line-associated bloodstream infection (A-CLABSI). Data describing risk factors of this infection in children are limited.METHODS: Retrospective cohort, single-center, case-crossover study of children ≤18 years old with SBS receiving HPN from January 2012 to December 2016. Univariate and multivariate mixed effect Poisson regression identified the relative risk (RR) of A-CLABSI with proposed risk factors.RESULTS: Thirty-five children were identified; median follow-up was 30 months. A-CLABSI rate was 4.2 per 1000 central line (CL) days. Univariate analysis identified younger age (RR: 0.92 per 12-month increase [95% confidence interval {CI}: 0.85-0.99; P = 0.036]), shorter small intestine length (RR: 0.96 per 10-cm increase [95% CI: 0.92-0.99; P = 0.008]), lower citrulline level (RR: 0.86 per 5-nmol/mL increase [95% CI: 0.75-0.99; P = 0.036]), and recent CL break (RR: 1.55 [95% CI: 1.06-2.28; P = 0.024]) as risk factors for A-CLABSI. Multivariate analysis showed increased A-CLABSI with clinical diagnosis of small intestine bacterial overgrowth (SIBO) (RR: 1.87 [95% CI: 1.1-3.17; P = 0.021]) and CL breaks (RR: 1.49 [95% CI: 1-2.22; P = 0.024]).CONCLUSIONS: Factors influencing gut integrity increase A-CLABSI rate, supporting translocation as an important mechanism and target for prevention. Clinical diagnosis of SIBO increases A-CLABSI rate, but whether dysbiosis or diarrhea is responsible is an area for future research. CL maintenance is crucial, and prevention of breaks would likely decrease A-CLABSI rate.

    View details for DOI 10.1002/jpen.1667

    View details for PubMedID 31179578