Regulating Stem Cell Function with Electrical Stimulation
WILEY. 2019: S277–S278
View details for Web of Science ID 000488891800447
Identification of New Therapeutic Pathways by Transcriptome Analysis of Electrically Stimulated-Neural Progenitor Cells After Stroke.
LIPPINCOTT WILLIAMS & WILKINS. 2019
View details for Web of Science ID 000478733400250
In vivo Electrical Stimulation of Neural Stem Cells via Conductive Polymer Scaffold Improves Endogenous Repair Mechanisms of Stroke Recovery
LIPPINCOTT WILLIAMS & WILKINS. 2018
View details for Web of Science ID 000453090802415
Electrically Conductive Scaffold to Modulate and Deliver Stem Cells
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
View details for DOI 10.3791/57367
View details for Web of Science ID 000444051300076
Electrically Conductive Scaffold to Modulate and Deliver Stem Cells.
Journal of visualized experiments : JoVE
Stem cell therapy has emerged as an exciting stroke therapeutic, but the optimal delivery method remains unclear. While the technique of microinjection has been used for decades to deliver stem cells in stroke models, this technique is limited by the lack of ability to manipulate the stem cells prior to injection. This paper details a method of using an electrically conductive polymer scaffold for stem cell delivery. Electrical stimulation of stem cells using a conductive polymer scaffold alters the stem cell's genes involved in cell survival, inflammatory response, and synaptic remodeling. After electrical preconditioning, the stem cells on the scaffold are transplanted intracranially in a distal middle cerebral artery occlusion rat model. This protocol describes a powerful technique to manipulate stem cells via a conductive polymer scaffold and creates a new tool to further develop stem cell-based therapy.
View details for PubMedID 29708538