Wenzhan Jing

All Publications

• Global incidence patterns of early-onset gastrointestinal cancers and their ecological associations with behavioural risk factors. Journal of global health Kang, L., Yan, W., He, J., Sun, H., Jing, W., Liu, J., Liu, M., Liang, W., Dong, J. 2026; 16: 04163

  Abstract

  Early-onset gastrointestinal cancers (EOGIC) are increasingly recognised as an urgent global health concern. We aimed to describe the global incidence patterns of EOGIC in 2022 and evaluate country-level ecological associations with behavioural risk factors.The incident cases and age-standardised incidence rates (ASIRs) of overall EOGIC, early-onset colorectal cancer (EOCRC), early-onset oesophageal cancer, early-onset gallbladder and biliary tract cancer, early-onset liver cancer (EOLC), early-onset pancreatic cancer (EOPC), and early-onset stomach cancer (EOSC) were extracted from the GLOBOCAN 2022 database. We used machine learning and generalised linear regression to screen and quantify the associations of behavioural risk factors and computed the model-based attributable fraction estimates.In 2022, an estimated 465 584 new EOGIC cases occurred globally (9.49% of all-age gastrointestinal cancers), with an ASIR = 11.50 per 100 000 persons. Early-onset colorectal cancer was the highest in both incident cases (n = 186 840), and ASIR = 4.60 per 100 000, followed by EOLC and EOSC. High Human Development Index countries (n = 205 168 incident cases, ASIR = 13.20 per 100 000) showed highest incidence of EOGIC. The highest number of EOGIC incident cases was in Eastern Asia (n = 147 677) and the highest ASIR occurred in Australia-New Zealand (ASIR = 18.70 per 100 000). In the ecological analyses, diet high in red meat and smoking showed the largest attributable fraction estimates for overall EOGIC incidence, at 12.78% and 8.17%, respectively. Smoking also showed comparatively larger estimates for EOCRC (11.29%) and EOPC (23.97%). High alcohol use was associated with nonzero attributable estimates for EOCRC (3.14%), early-onset oesophageal cancer (1.57%), EOLC (7.39%), EOPC (3.75%), and EOSC (6.88%), whereas diet high in sodium showed the largest estimate for EOSC (15.41%).Early-onset gastrointestinal cancer was a significant global health challenge, particularly for EOCRC and in high Human Development Index countries. These findings may help inform surveillance priorities and hypothesis generation for future etiologic research.

  View details for DOI 10.7189/jogh.16.04163

  View details for PubMedID 42170690

• Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study. BMC medicine Wang, Y., Tao, L., Lu, G., Chen, H., Jing, W., Jin, C., Liu, J. 2026

  Abstract

  Social participation and digital use are associated with reduced depression risk among older adults, but most supporting evidence does not consider both time-invariant and time-varying confounders and is inconsistent. We aimed to evaluate the impact of social participation and digital use on the incidence of depressive symptoms among older adults by a multi-country cohort considering both time-invariant and time-varying counfounders.We used data from four nationally representative observational studies across 18 countries (2008-2021): the Health and Retirement Study (HRS), the Survey of Health, Aging and Retirement in Europe (SHARE), the China Health and Retirement Longitudinal Study (CHARLS), and the Mexican Health and Aging Study (MHAS). Participants aged 50 years or older without depressive symptoms at baseline and without related behaviors pre-baseline were included. Interested exposure social participation and digital use were measured by specific questions. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) and the European Depression Scale (EURO-D). Targeted maximum likelihood estimation method was applied to estimate adjusted relative risks (RRs) and 95% confidence intervals (CIs) for the long-term impact of exposure on depressive symptoms onset.A total of 69,186 eligible participants were included. At baseline, 77.0%, 44.0%, 34.2%, and 49.8% of participants were exposed to social participation in HRS, SHARE, CHARLS, and MHAS, respectively, and these proportions were 55.7%, 55.9%, 4.5%, and 69.9% for digital use exposure. During follow-up, a total of 18,245 (26.4%) individuals developed depressive symptoms. The RRs (95% CI) of depression risk under social participation versus no social participation were 0.80 (0.68-0.93) in HRS, 0.80 (0.74-0.87) in SHARE, 0.86 (0.77-0.96) in CHARLS, and 0.93 (0.85-1.02) in MHAS. Compared with no digital use, the RRs (95% CI) of depression risk under digital use were 0.88 (0.72-1.08) in HRS, 0.85 (0.77-0.93) in SHARE, 0.75 (0.60-0.92) in CHARLS, and 0.88 (0.79-0.98) in MHAS.Engagement in social participation and digital use are associated with a reduced incidence of depressive symptoms in older adults. In the digital world, besides social participation, promoting digital use for social connection may be an effective strategy for depression prevention in ageing populations.

  View details for DOI 10.1186/s12916-026-04846-4

  View details for PubMedID 41947158

• Temporal trends and racial/ethnic disparities in hepatocellular carcinoma incidence in the US between 2000-2022. JHEP reports : innovation in hepatology Jing, W., Pham, H., So, S. 2026; 8 (4): 101754

  Abstract

  Hepatocellular carcinoma (HCC) in the US is largely driven by chronic hepatitis B in non-Hispanic Asians/Pacific Islanders (NH API) and chronic hepatitis C and metabolic dysfunction-associated steatotic liver disease in other racial/ethnic groups. We examined temporal trends and racial/ethnic disparities in HCC incidence in the US.The SEER-21 database (1 January 2000-31 December 2022) was used to identify adults aged ≥30 years diagnosed with HCC. Annual percentage changes (APC) in HCC incidence were estimated using Joinpoint regression.A total of 223,571 incident HCC cases were analyzed. The number of incident HCC cases increased from 4,758 in 2000 to a peak of 13,109 cases in 2019, followed by a decline to 11,853 cases in 2022, representing a 150% increase compared with 2000. Age-adjusted HCC incidence rates (AAIR) increased from 6.8 to a plateau of 12.4/100,000 in 2014 (APC2000-2007 = 5.6, APC2007-2014 = 3.2; p <0.05), before declining after 2019 to 10.5/100,000 by 2022 (APC2019-2022 = -3.9, p <0.05), remaining 54% higher than in 2000. NH API with the highest AAIR in 2000 (18.9/100,000), showed the earliest decline beginning in 2007 (APC2007-2015 = -1.8, APC2015-2022 = -4.8; p <0.05), nearly a decade before the other groups. AAIR began declining in NH Black and NH American Indian/Alaska Native populations in 2016, decreasing by 5.7% and 5.0% annually, respectively (p <0.05), and in 2019 in Hispanic and NH White, decreasing by 4.4% and 3.6% annually, respectively (p <0.05).HCC incidence trends varied by race/ethnicity. Declines may be partly associated with national hepatitis screening and treatment initiatives and professional guidelines, emphasizing continued efforts to address both viral and non-viral causes.Early declines among non-Hispanic Asians/Pacific Islanders likely reflect increased treatment for chronic hepatitis B, while later declines among the whole population were likely the result of national initiatives to scale up curative hepatitis C treatment. The high incidence of hepatocellular carcinoma (HCC) in Hispanic individuals warrants further studies and targeted interventions, including efforts to increase hepatitis C treatment access and reduce metabolic dysfunction-associated steatotic liver disease. These findings are important for clinicians and policymakers addressing HCC disparities and show that increased national initiatives to improve the diagnosis and treatment of chronic viral hepatitis are associated with a declining trend in HCC incidence at the population level.

  View details for DOI 10.1016/j.jhepr.2026.101754

  View details for PubMedID 41830878