Professional Education

  • MD/PhD, The University of Michigan, Medicine, Neuroscience (2019)

Contact

  • Academic
    University - Affiliate Department: Department Funds

Additional Info

All Publications

  • Preeclamptic iPSC-Derived Endothelial Cells Exhibit Global Dysfunction With Heterogeneous Defects In Nitric Oxide Signaling and Vascular Barrier Integrity Plummer, X., Wu, Y., Iyer, P., Sayed, N., Winn, V. SPRINGER HEIDELBERG. 2026

    View details for Web of Science ID 001737538601029

  • Perinatal use of non-alcoholic beverages that mirror alcohol. American journal of obstetrics and gynecology Bowdring, M. A., Sperling, M. M., Plummer, X. D., Prochaska, J. J. 2025

    View details for DOI 10.1016/j.ajog.2025.04.016

    View details for PubMedID 40228708

  • Preeclamptic and Normotensive iPSC-Derived Endothelial Cells Have Distinct Responses to Maternal Circulating Factors Plummer, X. D., Wu, Y., Iyer, P., Medina, P., Sayed, N., Winn, V. D. SPRINGER HEIDELBERG. 2025: 69A

    View details for Web of Science ID 001609923000066

  • What Accounts for the Increased Risk of HDP Seen with Donor and Autologous Egg IVF Pregnancies? Yang, R., Zhang, W. Y., Sherwin, E. B., Iyer, P. N., Sehgal, S., Plummer, X., Baker, V., Lathi, R., Winn, V. D. SPRINGER HEIDELBERG. 2025: 148A

    View details for Web of Science ID 001609923000297

  • Persistence of a Proteomic Signature After a Hypertensive Disorder of Pregnancy. Hypertension (Dallas, Tex. : 1979) Hlatky, M. A., Shu, C. H., Stevenson, D. K., Shaw, G. M., Stefanick, M. L., Boyd, H. A., Melbye, M., Plummer, X. D., Sedan, O., Wong, R. J., Aghaeepour, N., Winn, V. D. 2025

    Abstract

    A hypertensive disorder of pregnancy is associated with a higher risk of cardiovascular disease later in life, but the potential mechanistic links are unknown.We recruited 2 groups of women, 1 during pregnancy and another at least 2 years after delivery. Cases had a hypertensive disorder of pregnancy, and controls had a normotensive pregnancy. The pregnancy cohort had study visits antepartum and postpartum; the mid-life group made a single study visit. We assayed 7228 plasma proteins, applied machine learning to identify proteomics signatures at each time point, and performed enrichment analyses to identify relevant biological pathways.The pregnancy cohort (58 cases and 46 controls) had a mean age of 33.8 years, and the mid-life group (71 cases and 74 controls) had a mean age of 40.8 years. Protein levels differed significantly between cases and controls at each time point: 6233 antepartum, 189 postpartum, and 224 in mid-life. The postpartum protein signature discriminated well between cases and controls (c-index=0.78), and it also discriminated well in the independent mid-life samples (c-index=0.72). Pathway analyses identified differences in the complement and coagulation cascades that persisted across the antepartum, postpartum, and mid-life samples. The 28 proteins present in both the postpartum and mid-life signatures included 5 complement factors (3, B, H, H-related-1, and C1r-subcomponent-like) and coagulation factor IX.Differences in protein expression persist for years after a hypertensive disorder of pregnancy. The consistent differences in the complement and coagulation pathways may contribute to the increased risk of later life cardiovascular disease.

    View details for DOI 10.1161/HYPERTENSIONAHA.124.24490

    View details for PubMedID 39981573

https://orcid.org/0000-0003-1581-5053