Professional Education

  • Doctor of Philosophy, Peking Academy (2020)
  • Bachelor of Science, Peking Academy (2015)
  • PhD, Peking University, Chemical biology (2020)

Stanford Advisors

Contact

  • Academic
    daoyk@stanford.edu
    University - Scholar Department: Pediatrics Position: Postdoctoral Scholar

Additional Info

All Publications

  • Modulation of insulin receptor activation through controlled folding of peptide ligands. Organic & biomolecular chemistry Li, W., Dao, Y., Lin, T., Austin, M. J., Lin, N. P., Chou, D. H. 2025

    Abstract

    Insulin receptor (IR) activation requires coordinated engagement of two distinct insulin-binding sites, and recent structural insights have highlighted the role of a disulfide bond in IR agonist S597 in the S597-IR complex. In this study, we synthesized and evaluated analogs of S597 and the IR antagonist Ins-AC-S2, replacing their native disulfide bridges with alternative linkages. While these modifications had minimal impact on Ins-AC-S2's antagonistic activity, they significantly reduced the agonistic potency of S597, suggesting that conformational stability is critical for receptor activation. Our findings provide a structural basis for designing non-insulin ligands to selectively activate or inhibit the insulin receptor, with potential therapeutic implications.

    View details for DOI 10.1039/d5ob00363f

    View details for PubMedID 40277138

https://orcid.org/0009-0007-2349-1913