Yunji Seo

All Publications

• Heparin Resistance During Iliocaval Thrombectomy in a Hypercoagulable Patient. Journal of vascular and interventional radiology : JVIR Seo, Y., Ahuja, T., Chen, M., Ranade, M. 2026: 109018

  View details for DOI 10.1016/j.jvir.2026.109018

  View details for PubMedID 42575464

• GPNMB confers risk for Parkinson's disease through interaction with alpha-synuclein SCIENCE Diaz-Ortiz, M. E., Seo, Y., Posavi, M., Cordon, M., Clark, E., Jain, N., Charan, R., Gallagher, M. D., Unger, T. L., Amari, N., Skrinak, R., Davila-Rivera, R., Brody, E. M., Han, N., Zack, R., Van Deerlin, V. M., Tropea, T. F., Luk, K. C., Lee, E. B., Weintraub, D., Chen-Plotkin, A. S. 2022; 377 (6608): 833-+

  Abstract

  Many risk loci for Parkinson's disease (PD) have been identified by genome-wide association studies (GWASs), but target genes and mechanisms remain largely unknown. We linked the GWAS-derived chromosome 7 locus (sentinel single-nucleotide polymorphism rs199347) to GPNMB through colocalization analyses of expression quantitative trait locus and PD risk signals, confirmed by allele-specific expression studies in the human brain. In cells, glycoprotein nonmetastatic melanoma protein B (GPNMB) coimmunoprecipitated and colocalized with α-synuclein (aSyn). In induced pluripotent stem cell-derived neurons, loss of GPNMB resulted in loss of ability to internalize aSyn fibrils and develop aSyn pathology. In 731 PD and 59 control biosamples, GPNMB was elevated in PD plasma, associating with disease severity. Thus, GPNMB represents a PD risk gene with potential for biomarker development and therapeutic targeting.

  View details for DOI 10.1126/science.abk0637

  View details for Web of Science ID 000843601300035

  View details for PubMedID 35981040

• Mechanical Thrombectomy in Septic Thrombophlebitis: Patterns of Use and Clinician Perspectives CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY Seo, Y., Chick, J. F. B., Laidlaw, G., Ranade, M. 2026

  View details for DOI 10.1007/s00270-026-04571-8

  View details for Web of Science ID 001863240100001

  View details for PubMedID 42669774

• Successful Lymphatic Embolization for Genital Lymphorrhea in the Setting of Chronic Venous Insufficiency. Journal of vascular and interventional radiology : JVIR Seo, Y., Loening, A. M., Hung, M. L. 2026: 108845

  View details for DOI 10.1016/j.jvir.2026.108845

  View details for PubMedID 42107702

• Whole-genome 3D architectural screen reveals modulators of brain DNA structure in vivo Venkatesh, A., Parasar, B., Sosnick, L., Moghadami, S., Seo, Y., Shi, J., Chan, L., Hadjipanayis, A., Tan, L. CELL PRESS. 2026

  View details for Web of Science ID 001717804800275

• GPNMB Biomarker Levels in GBA1 Carriers with Lewy Body Disorders. Movement disorders : official journal of the Movement Disorder Society Brody, E. M., Seo, Y., Suh, E., Amari, N., Hartstone, W. G., Skrinak, R. T., Zhang, H., Diaz-Ortiz, M. E., Weintraub, D., Tropea, T. F., Van Deerlin, V. M., Chen-Plotkin, A. S. 2024

  Abstract

  The GPNMB single-nucleotide polymorphism rs199347 and GBA1 variants both associate with Lewy body disorder (LBD) risk. GPNMB encodes glycoprotein nonmetastatic melanoma protein B (GPNMB), a biomarker for GBA1-associated Gaucher's disease.The aim of this study was to determine whether GPNMB levels (1) differ in LBD with and without GBA1 variants and (2) associate with rs199347 genotype.We quantified GPNMB levels in plasma and cerebrospinal fluid (CSF) from 124 individuals with LBD with one GBA1 variant (121 plasma, 14 CSF), 631 individuals with LBD without GBA1 variants (626 plasma, 41 CSF), 9 neurologically normal individuals with one GBA1 variant (plasma), and 2 individuals with two GBA1 variants (plasma). We tested for associations between GPNMB levels and rs199347 or GBA1 status.GPNMB levels associate with rs199347 genotype in plasma (P = 0.022) and CSF (P = 0.007), but not with GBA1 status.rs199347 is a protein quantitative trait locus for GPNMB. GPNMB levels are unaltered in individuals carrying one GBA1 variant. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

  View details for DOI 10.1002/mds.29773

  View details for PubMedID 38610104

• Lifelong restructuring of 3D genome architecture in cerebellar granule cells. Science (New York, N.Y.) Tan, L., Shi, J., Moghadami, S., Parasar, B., Wright, C. P., Seo, Y., Vallejo, K., Cobos, I., Duncan, L., Chen, R., Deisseroth, K. 2023; 381 (6662): 1112-1119

  Abstract

  The cerebellum contains most of the neurons in the human brain and exhibits distinctive modes of development and aging. In this work, by developing our single-cell three-dimensional (3D) genome assay-diploid chromosome conformation capture, or Dip-C-into population-scale (Pop-C) and virus-enriched (vDip-C) modes, we resolved the first 3D genome structures of single cerebellar cells, created life-spanning 3D genome atlases for both humans and mice, and jointly measured transcriptome and chromatin accessibility during development. We found that although the transcriptome and chromatin accessibility of cerebellar granule neurons mature in early postnatal life, 3D genome architecture gradually remodels throughout life, establishing ultra-long-range intrachromosomal contacts and specific interchromosomal contacts that are rarely seen in neurons. These results reveal unexpected evolutionarily conserved molecular processes that underlie distinctive features of neural development and aging across the mammalian life span.

  View details for DOI 10.1126/science.adh3253

  View details for PubMedID 37676945