Academic Appointments

All Publications

  • "Double-sided protector" Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects. Journal of nanobiotechnology Xu, L., Zhang, J., Luo, J., Cui, Y., Chen, J., Zeng, B., Deng, Z., Shao, L. 2025; 23 (1): 387

    Abstract

    Skin and mucous membranes serve as crucial barrier tissues within the human body. Defective wound healing not only inflicts pain but also heightens the risk of infection and impairs immune function. Janus hydrogels possess two-sided distinct asymmetric structures that endow them with diverse properties such as high water absorbency, flexibility, anti-adhesion ability etc. These hydrogels also exhibit great potential in biofluid transport, drug delivery and promoting tissue repair. Currently, research efforts predominantly concentrate on the preparation techniques, properties, and biomedical applications. This review summarized its structural characteristics and different forms of designations, and focused on the possible mechanisms, the existing problems and improvement strategies for the skin and mucous tissues wound, aiming to provide new design ideas for repairing complex skin and mucous membrane tissue defects.

    View details for DOI 10.1186/s12951-025-03438-3

    View details for PubMedID 40426120

    View details for PubMedCentralID PMC12117736

  • Layered double hydroxides for regenerative nanomedicine and tissue engineering: recent advances and future perspectives. Journal of nanobiotechnology Luo, J., Cui, Y., Xu, L., Zhang, J., Chen, J., Li, X., Zeng, B., Deng, Z., Shao, L. 2025; 23 (1): 370

    Abstract

    With the rapid development of nanotechnology, layered double hydroxides (LDHs) have attracted considerable attention in the biomedical field due to their highly tunable composition and structure, superior biocompatibility, multifunctional bioactivity, and exceptional drug delivery performance. However, a focused and comprehensive review addressing the role of LDHs specifically in tissue regeneration has been lacking. This review aims to fill that gap by providing a systematic and in-depth overview of recent advances in the application of LDHs across various regenerative domains, including bone repair, cartilage reconstruction, angiogenesis, wound healing, and nerve regeneration. Beyond presenting emerging applications, the review places particular emphasis on elucidating the underlying mechanisms through which LDHs exert their therapeutic effects. Although LDHs demonstrate considerable promise in regenerative medicine, their clinical translation remains in its infancy. To address this, we not only provided our insights into the personalized problems that arise in the application of various tissues, but also focused on discussing and prospecting the common challenges in the clinical translation of LDHs. These challenges include optimizing synthesis techniques, enhancing biosafety and stability, improving drug-loading efficiency, designing multifunctional composite materials, and establishing pathways that facilitate the transition from laboratory research to clinical practice.

    View details for DOI 10.1186/s12951-025-03448-1

    View details for PubMedID 40405242

    View details for PubMedCentralID 9694224