Zinan Hu

All Publications

• Cardiovascular fluid dynamics: a journey through our circulation FLOW Menon, K., Hu, Z., Marsden, A. L. 2024; 4

  View details for DOI 10.1017/flo.2024.5

  View details for Web of Science ID 001221235200001

• IMPACT OF CARDIAC FIBER ORIENTATION ON ELECTRICAL DYSSYNCHRONY IN VENTRICULAR ECTOPY Perkins, S. J., Salvador, M., Hu, Z., Tikenogullari, O., Kong, F., Narayan, S. M., Marsden, A. ELSEVIER SCIENCE INC. 2024: 88

  View details for Web of Science ID 001291434300089

• A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics. Computer methods in applied mechanics and engineering Brown, A. L., Salvador, M., Shi, L., Pfaller, M. R., Hu, Z., Harold, K. E., Hsiai, T., Vedula, V., Marsden, A. L. 2024; 421

  Abstract

  In numerical simulations of cardiac mechanics, coupling the heart to a model of the circulatory system is essential for capturing physiological cardiac behavior. A popular and efficient technique is to use an electrical circuit analogy, known as a lumped parameter network or zero-dimensional (0D) fluid model, to represent blood flow throughout the cardiovascular system. Due to the strong physical interaction between the heart and the blood circulation, developing accurate and efficient numerical coupling methods remains an active area of research. In this work, we present a modular framework for implicitly coupling three-dimensional (3D) finite element simulations of cardiac mechanics to 0D models of blood circulation. The framework is modular in that the circulation model can be modified independently of the 3D finite element solver, and vice versa. The numerical scheme builds upon a previous work that combines 3D blood flow models with 0D circulation models (3D fluid - 0D fluid). Here, we extend it to couple 3D cardiac tissue mechanics models with 0D circulation models (3D structure - 0D fluid), showing that both mathematical problems can be solved within a unified coupling scheme. The effectiveness, temporal convergence, and computational cost of the algorithm are assessed through multiple examples relevant to the cardiovascular modeling community. Importantly, in an idealized left ventricle example, we show that the coupled model yields physiological pressure-volume loops and naturally recapitulates the isovolumic contraction and relaxation phases of the cardiac cycle without any additional numerical techniques. Furthermore, we provide a new derivation of the scheme inspired by the Approximate Newton Method of Chan (1985), explaining how the proposed numerical scheme combines the stability of monolithic approaches with the modularity and flexibility of partitioned approaches.

  View details for DOI 10.1016/j.cma.2024.116764

  View details for PubMedID 38523716

  View details for PubMedCentralID PMC10956732

• Computational approaches for mechanobiology in cardiovascular development and diseases. Current topics in developmental biology Brown, A. L., Sexton, Z. A., Hu, Z., Yang, W., Marsden, A. L. 2024; 156: 19-50

  Abstract

  The cardiovascular development in vertebrates evolves in response to genetic and mechanical cues. The dynamic interplay among mechanics, cell biology, and anatomy continually shapes the hydraulic networks, characterized by complex, non-linear changes in anatomical structure and blood flow dynamics. To better understand this interplay, a diverse set of molecular and computational tools has been used to comprehensively study cardiovascular mechanobiology. With the continual advancement of computational capacity and numerical techniques, cardiovascular simulation is increasingly vital in both basic science research for understanding developmental mechanisms and disease etiologies, as well as in clinical studies aimed at enhancing treatment outcomes. This review provides an overview of computational cardiovascular modeling. Beginning with the fundamental concepts of computational cardiovascular modeling, it navigates through the applications of computational modeling in investigating mechanobiology during cardiac development. Second, the article illustrates the utility of computational hemodynamic modeling in the context of treatment planning for congenital heart diseases. It then delves into the predictive potential of computational models for elucidating tissue growth and remodeling processes. In closing, we outline prevailing challenges and future prospects, underscoring the transformative impact of computational cardiovascular modeling in reshaping cardiovascular science and clinical practice.

  View details for DOI 10.1016/bs.ctdb.2024.01.006

  View details for PubMedID 38556423

• A modular framework for implicit 3D-0D coupling in cardiac mechanics COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING Brown, A. L., Salvador, M., Shi, L., Pfaller, M. R., Hu, Z., Harold, K. E., Hsiai, T., Vedula, V., Marsden, A. L. 2024; 421

  View details for DOI 10.1016/j.cma.2024.116764

  View details for Web of Science ID 001170690900001