All Publications

  • Aspirin for the primary prevention of cardiovascular disease in the elderly. BMJ evidence-based medicine O'Sullivan, J. W. 2019

    View details for PubMedID 30733220

  • Introducing the EBM Verdict: research evidence relevant to clinical practice. BMJ evidence-based medicine Heneghan, C., Brassey, J., Aronson, J., O'Sullivan, J. W. 2019

    View details for PubMedID 30700435

  • Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests. BMJ (Clinical research ed.) O'Sullivan, J. W., Stevens, S., Hobbs, F. D., Salisbury, C., Little, P., Goldacre, B., Bankhead, C., Aronson, J. K., Perera, R., Heneghan, C. 2018; 363: k4666


    OBJECTIVES: To assess the temporal change in test use in UK primary care and to identify tests with the greatest increase in use.DESIGN: Retrospective cohort study.SETTING: UK primary care.PARTICIPANTS: All patients registered to UK General Practices in the Clinical Practice Research Datalink, 2000/1 to 2015/16.MAIN OUTCOME MEASURES: Temporal trends in test use, and crude and age and sex standardised rates of total test use and of 44 specific tests.RESULTS: 262974099 tests were analysed over 71436331 person years. Age and sex adjusted use increased by 8.5% annually (95% confidence interval 7.6% to 9.4%); from 14869 tests per 10000 person years in 2000/1 to 49267 in 2015/16, a 3.3-fold increase. Patients in 2015/16 had on average five tests per year, compared with 1.5 in 2000/1. Test use also increased statistically significantly across all age groups, in both sexes, across all test types (laboratory, imaging, and miscellaneous), and 40 of the 44 tests that were studied specifically.CONCLUSION: Total test use has increased markedly over time, in both sexes, and across all age groups, test types (laboratory, imaging, and miscellaneous) and for 40 of 44 tests specifically studied. Of the patients who underwent at least one test annually, the proportion who had more than one test increased significantly over time.

    View details for PubMedID 30487169