Matthew Ricks
Ph.D. Student in Biomedical Physics, admitted Autumn 2023
All Publications
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Effect of pressure cycling and compression rate on the bcc-hcp transition in an FeNi alloy
APPLIED PHYSICS LETTERS
2025; 127 (26)
View details for DOI 10.1063/5.0300182
View details for Web of Science ID 001650517000007
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Ultrasensitive and multiplexed tracking of single cells using whole-body PET/CT.
Science advances
2024; 10 (24): eadk5747
Abstract
In vivo molecular imaging tools are crucially important for elucidating how cells move through complex biological systems; however, achieving single-cell sensitivity over the entire body remains challenging. Here, we report a highly sensitive and multiplexed approach for tracking upward of 20 single cells simultaneously in the same subject using positron emission tomography (PET). The method relies on a statistical tracking algorithm (PEPT-EM) to achieve a sensitivity of 4 becquerel per cell and a streamlined workflow to reliably label single cells with over 50 becquerel per cell of 18F-fluorodeoxyglucose (FDG). To demonstrate the potential of the method, we tracked the fate of more than 70 melanoma cells after intracardiac injection and found they primarily arrested in the small capillaries of the pulmonary, musculoskeletal, and digestive organ systems. This study bolsters the evolving potential of PET in offering unmatched insights into the earliest phases of cell trafficking in physiological and pathological processes and in cell-based therapies.
View details for DOI 10.1126/sciadv.adk5747
View details for PubMedID 38875333
View details for PubMedCentralID PMC11177933
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Phase transition kinetics revealed by in situ x-ray diffraction in laser-heated dynamic diamond anvil cells
PHYSICAL REVIEW RESEARCH
2024; 6 (1)
View details for DOI 10.1103/PhysRevResearch.6.013316
View details for Web of Science ID 001195482400003