Abel Joseph

All Publications

• Novel Modified Endoscopic Suction Overtube for Clearance of Gastric Blood Clots During Urgent Upper Endoscopy Joseph, A., Li, A., Friedland, S. LIPPINCOTT WILLIAMS & WILKINS. 2024: S2153

  View details for DOI 10.14309/01.ajg.0001042120.39605.12

  View details for Web of Science ID 001359318700041

• Esophageal Distensibility Changes as Measured by EndoFLIP in Different Esophageal Motility Disorders Joseph, A., Achalu, S., Triadafilopoulos, G., Clarke, J., Kamal, A. LIPPINCOTT WILLIAMS & WILKINS. 2024: S405-S406

  View details for DOI 10.14309/01.ajg.0001031716.26674.cc

  View details for Web of Science ID 001360324500041

• Timing of Index Ileocolic Resection is Associated With Radiographic Recurrence in Patients With Crohn's Disease Li, E. S., Li, T., Shah, R., Click, B., Ryan, D. R., Cohen, B. L., Barnes, E., Joseph, A., Bachour, S., Hu, J., Contreras, S., Axelrad, J. LIPPINCOTT WILLIAMS & WILKINS. 2024: S962-S963

  View details for DOI 10.14309/01.ajg.0001034752.01061.8f

  View details for Web of Science ID 001365068500038

• Efficacy and safety of covered self-expandable metal stent for malignant hilar biliary obstruction: A systematic review and meta-analysis. Gastrointestinal endoscopy Chung, K. H., Lee, K. J., Joseph, A. A., Huang, R. J., Li, A., Hwang, J. H., Yoon, S. B. 2024

  Abstract

  Covered self-expanding metal stents (C-SEMS) are used for malignant hilar biliary obstruction (MHBO) management. Despite increasing evidence, comprehensive evaluation of the efficacy and safety of C-SEMS in MHBO management is lacking.PubMed, EMBASE, and the Cochrane Library were screened up to March 31, 2024 for studies including MHBO treated by a C-SEMS. Studies meeting predefined inclusion criteria, including adult MHBO patients treated with C-SEMS placement, reporting technical success, clinical success, and adverse event rates, were selected. Data synthesis and statistical analysis were performed using the random effects model, with heterogeneity and publication bias assessment.From 401 articles, seven studies were included. Pooled technical and clinical success rate of C-SEMS was 96.7% (95% CI 92.6-98.6%, I2=0%) and 91.6% (95% CI 86.1-95.0%, I2=0%). Overall adverse events were reported in 16.6% (95% CI 11.2-23.9%, I2=24%) of cases which included cholangitis (7.4%), pancreatitis (5.9%), liver abscess (5.9%), and cholecystitis (2.8%). Stent migration and recurrent biliary obstruction were observed in 8.9% and 49.6% of cases, respectively, with a median time to recurrent biliary obstruction of 142 days. Reintervention was successful in 92.5% of cases (95% CI 83.1-96.9%, I2=0%) CONCLUSION: Our meta-analysis revealed high technical and clinical success rates of C-SEMS in MHBO. Adverse events, notably cholangitis, cholecystitis, and pancreatitis were <10%. RBO and stent migration was mitigated by C-SEMS removal and successful reintervention. Our findings highlight the efficacy and safety of C-SEMS in managing MHBO, warranting further research to optimize treatment strategies.

  View details for DOI 10.1016/j.gie.2024.09.037

  View details for PubMedID 39357660

• Esophageal Expert Development of a Preliminary Question Prompt List for Adults With Eosinophilic Esophagitis: A Modified Delphi Study. Journal of clinical gastroenterology Achalu, S., Berry, R., Joseph, A., Bhargava, M., Fernandez-Becker, N. Q., Bredenoord, A. J., Chang, J., Dellon, E., Falk, G., Hirano, I., Horsley-Silva, J., Leiman, D. A., Lynch, K. L., Peterson, K., Kamal, A. N. 2024

  Abstract

  Question prompt lists (QPLs) are structured sets of disease-specific questions intended to encourage question-asking by patients and enhance patient-physician communication. To date, an EoE-specific QPL has not been developed for EoE patients.To develop a preliminary QPL specific to adults with EoE by incorporating input from international esophageal experts.Sixteen experts were invited to generate QPL content through a modified Delphi (RAND/University of California, Los Angeles, CA) method consisting of 2 rounds of independent ratings. In round 1, experts provided 5 answers to the prompts "what general questions should patients ask when being seen for EoE?" and "what questions do I not hear patients asking but given my experience, I believe they should be asking?" In round 2, experts rated each question on a 5-point Likert scale, and responses rated as "essential" or "important" (determined by an a priori median threshold of ≥ 4.0) were accepted for the EoE QPL.Ten esophageal experts participated in both rounds. Round 1 generated 100 questions. Questions were combined and modified to reduce redundancy, yielding 57 questions. After round 2, 51 questions (85%) were accepted for inclusion (median value ≥ 4.0) in the final QPL. Questions were then divided into 4 themes based on disease domains: (1) "What is EoE?," (2) "Treatment Options," (3) "Follow-up Surveillance and Long-term Risks," and (4) "Allergy and Genetic Testing." The largest number of questions covered was "What is EoE?" (16/51 or 31%). Questions with the highest agreement median (5.0) included examples such as "what should I do if I get a food impaction?" and "what are the treatment options?"This is the first preliminary EoE QPL developed in the field of medicine. We hope implementation enhances effective patient-physician communication by encouraging patients to ask relevant questions that experts prioritized. Future studies will aim to modify this communication tool by incorporating patient perspectives.

  View details for DOI 10.1097/MCG.0000000000002066

  View details for PubMedID 39312545

• What's Behind it all: A Retrospective Cohort Study of Retrogastric Pancreatic Necrosis Management. Annals of surgery Harrison, J. M., Day, H., Arnow, K., Ngongoni, R. F., Joseph, A., Aldridge, T., Wheeler, K. J., DeLong, J. C., Bergquist, J. R., Worth, P. J., Dua, M. M., Friedland, S., Park, W., Eldika, S., Hwang, J. H., Visser, B. C. 2024

  Abstract

  To compare outcomes of laparoscopic transgastric necrosectomy (LTN) and direct endoscopic necrosectomy (DEN) in the management of retrogastric walled-off necrosis.Surgical and endoscopic transgastric approaches are used to manage retrogastric pancreatic necrosis. Studies comparing these treatment modalities are lacking but would influence contemporary practice patterns.LTN or DEN treated patients at Stanford University Hospital between 2011 and 2023 were identified. Cohort data included demographics, core pancreatitis care benchmarks, and clinical outcomes (total debridement time, new-onset endocrine and exocrine pancreatic insufficiency) as well as re-intervention, 30-day readmission, complication, and mortality rates. Long-term follow-up was also compared between intervention arms. Multivariable linear regression was used to assess the interaction between admission APACHE-II score and intervention on length of stay (LOS).106 patients (62% LTN, 38% DEN) were identified. Demographic and core pancreatitis benchmark data were similar between cohorts. 30-day readmission, complication, and mortality rates for surgical and endoscopic approaches were also similar: 23% vs. 25% (P = 0.98), 42% vs. 40% (P = 0.97), and 3% vs. 3% (P > 0.99). Median LTN total debridement time (minutes) was 131 vs. 134 for DEN, however, complete debridement was achieved with only 1 LTN compared to 3 DENs (P<0.01). While not statistically significant, LOS and unplanned intervention rates were less for LTN (8 vs. 10 days, P = 0.41 and 6% vs. 15%, P = 0.24). Multivariable analysis revealed a significant interaction between APACHE-II scores and LOS for LTN compared to DEN, which translated into a length of stay reduction for higher APACHE-II scoring patients (P = 0.02).LTN is a safe and efficient treatment modality for walled-off necrosis, and compared to DEN, can reduce the LOS in high APACHE-II score patients. While additional comparative research between the two intervention types is needed, this study supports a role for a surgical approach in the management of retrogastric pancreatic necrosis.

  View details for DOI 10.1097/SLA.0000000000006521

  View details for PubMedID 39225420

• Rates of Recurrent Intestinal Metaplasia and Dysplasia After Successful Endoscopic Therapy of Barrett's Neoplasia by Endoscopic Mucosal Resection vs Endoscopic Submucosal Dissection and Ablation: A Large North American Multicenter Cohort AMERICAN JOURNAL OF GASTROENTEROLOGY Vantanasiri, K., Joseph, A., Sachdeva, K., Goyal, R., Garg, N., Adoor, D., Kamboj, A. K., Codipilly, D., Leggett, C., Wang, K. K., Harmsen, W., Hayat, U., Chak, A., Bhatt, A., Iyer, P. G. 2024; 119 (9): 1831-1840

  Abstract

  Endoscopic eradication therapy (EET) combining endoscopic resection (ER) with endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) followed by ablation is the standard of care for the treatment of dysplastic Barrett's esophagus (BE). We have previously shown comparable rates of complete remission of intestinal metaplasia (CRIM) with both approaches. However, data comparing recurrence after CRIM are lacking. We compared rates of recurrence after CRIM with both techniques in a multicenter cohort.Patients undergoing EET achieving CRIM at 3 academic institutions were included. Demographic and clinical data were abstracted. Outcomes included rates and predictors of any BE and dysplastic BE recurrence in the 2 groups. Cox-proportional hazards models and inverse probability treatment weighting (IPTW) analysis were used for analysis.A total of 621 patients (514 EMR and 107 ESD) achieving CRIM were included in the recurrence analysis. The incidence of any BE (15.7, 5.7 per 100 patient-years) and dysplastic BE recurrence (7.3, 5.3 per 100 patient-years) were comparable in the EMR and ESD groups, respectively. On multivariable analyses, the chances of BE recurrence were not influenced by ER technique (hazard ratio 0.87; 95% confidence interval 0.51-1.49; P = 0.62), which was also confirmed by IPTW analysis (ESD vs EMR: hazard ratio 0.98; 95% confidence interval 0.56-1.73; P = 0.94). BE length, lesion size, and history of cigarette smoking were independent predictors of BE recurrence.Patients with BE dysplasia/neoplasia achieving CRIM, initially treated with EMR/ablation, had comparable recurrence rates to ESD/ablation. Randomized trials are needed to confirm these outcomes between the 2 ER techniques.

  View details for DOI 10.14309/ajg.0000000000002798

  View details for Web of Science ID 001308355500029

  View details for PubMedID 38587280

• Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study 2021. The lancet. Gastroenterology & hepatology 2024

  Abstract

  Appendicitis is a common surgical emergency that poses a large clinical and economic burden. Understanding the global burden of appendicitis is crucial for evaluating unmet needs and implementing and scaling up intervention services to reduce adverse health outcomes. This study aims to provide a comprehensive assessment of the global, regional, and national burden of appendicitis, by age and sex, from 1990 to 2021.Vital registration and verbal autopsy data, the Cause of Death Ensemble model (CODEm), and demographic estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) were used to estimate cause-specific mortality rates (CSMRs) for appendicitis. Incidence data were extracted from insurance claims and inpatient discharge sources and analysed with disease modelling meta-regression, version 2.1 (DisMod-MR 2.1). Years of life lost (YLLs) were estimated by combining death counts with standard life expectancy at the age of death. Years lived with disability (YLDs) were estimated by multiplying incidence estimates by an average disease duration of 2 weeks and a disability weight for abdominal pain. YLLs and YLDs were summed to estimate disability-adjusted life-years (DALYs).In 2021, the global age-standardised mortality rate of appendicitis was 0·358 (95% uncertainty interval [UI] 0·311-0·414) per 100 000. Mortality rates ranged from 1·01 (0·895-1·13) per 100 000 in central Latin America to 0·054 (0·0464-0·0617) per 100 000 in high-income Asia Pacific. The global age-standardised incidence rate of appendicitis in 2021 was 214 (174-274) per 100 000, corresponding to 17 million (13·8-21·6) new cases. The incidence rate was the highest in high-income Asia Pacific, at 364 (286-475) per 100 000 and the lowest in western sub-Saharan Africa, at 81·4 (63·9-109) per 100 000. The global age-standardised rates of mortality, incidence, YLLs, YLDs, and DALYs due to appendicitis decreased steadily between 1990 and 2021, with the largest reduction in mortality and YLL rates. The global annualised rate of decline in the DALY rate was greatest in children younger than the age of 10 years. Although mortality rates due to appendicitis decreased in all regions, there were large regional variations in the temporal trend in incidence. Although the global age-standardised incidence rate of appendicitis has steadily decreased between 1990 and 2021, almost half of GBD regions saw an increase of greater than 10% in their age-standardised incidence rates.Slow but promising progress has been observed in reducing the overall burden of appendicitis in all regions. However, there are important geographical variations in appendicitis incidence and mortality, and the relationship between these measures suggests that many people still do not have access to quality health care. As the incidence of appendicitis is rising in many parts of the world, countries should prepare their health-care infrastructure for timely, high-quality diagnosis and treatment. Given the risk that improved diagnosis may counterintuitively drive apparent rising trends in incidence, these efforts should be coupled with improved data collection, which will also be crucial for understanding trends and developing targeted interventions.Bill and Melinda Gates Foundation.

  View details for DOI 10.1016/S2468-1253(24)00157-2

  View details for PubMedID 39032499

• Histologic Activity from Neoterminal Ileal Biopsies in Patients with Crohn's Disease in Endoscopic Remission is Associated with Postoperative Recurrence. The American journal of gastroenterology Shah, R. S., Hu, J. H., Bachour, S., Joseph, A., Syed, H., Yang, Q., Ali, A. H., Li, T., Contreras, S., Pothula, S., Vinaithirthan, V., Regueiro, M., Axelrad, J., Barnes, E. L., Cohen, B. L., Click, B. H. 2024

  Abstract

  Following ileocolic resection (ICR), the clinical importance and prognostic implications of histologic activity on biopsies in Crohn's disease (CD) patients with endoscopic remission are not well defined. This study aimed to determine if histologic activity in patients with endoscopic remission is associated with future risk of endoscopic and/or radiologic postoperative recurrence (POR).In this multicenter retrospective cohort study, adult patients with CD who underwent ICR between 2009-2020 with endoscopic biopsies of ileal mucosa from Rutgeerts' i0 on index colonoscopy were included. The composite rate of endoscopic (Rutgeerts' score≥i2b) and radiologic (active inflammation on imaging) recurrence was compared in patients with and without histologic activity using a Kaplan-Meier survival analysis. A multivariable Cox proportional hazard regression model including clinically relevant risk factors for POR, postoperative biologic prophylaxis, and histology activity was designed.A total of 113 patients with i0 disease on index colonoscopy after ICR were included. Of these, 42% had histologic activity. Time to POR was significantly earlier in the histologically active versus normal group (p=0.04). After adjusting for clinical risk factors for POR, histologic activity (HR 2.37, 95% CI 1.17-4.79; p=0.02) and active smoking (HR 2.54, 95% CI 1.02-6.33; p=0.05) were independently associated with subsequent composite POR risk.In patients with postoperative CD, histologic activity despite complete endoscopic remission is associated with composite, endoscopic and radiographic, recurrence. Further understanding of the role of histologic activity in patients with Rutgeerts' i0 disease may provide a novel target to reduce disease recurrence in this population.

  View details for DOI 10.14309/ajg.0000000000002963

  View details for PubMedID 39007494

• OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL ESOPHAGEAL SQUAMOUS NEOPLASMS: A MULTICENTER NORTH AMERICAN EXPERIENCE Subrahmanyan, R., Almario, J., Aihara, H., Kumar, A., Schlachterman, A., Friedland, S., Hwang, J., Othman, M., Jawaid, S., Ferri, L., Teshima, C., Mosko, J., Bechara, R., Samarasena, J., Yang, D., Ujiki, M., Tomizawa, Y., Schiavone, G., Madaka, P., Joseph, A., Li, A., Khalaf, M., Qatomah, A., Al-Shamali, H., Dang, F., Tavangar, A., Rwigema, J., King, W., Northern, N., Draganov, P., Ngamruengphong, S. MOSBY-ELSEVIER. 2024: AB1068-AB1069

  View details for Web of Science ID 001278323004174

• LONG TERM OUTCOMES OF NON-CURATIVE ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL LESIONS Almario, J., Hiroyuki, A., Kumar, A., Schlachterman, A., Maluf-Filho, F., Othman, M., Jawaid, S., Teshima, C., Mosko, J., Draganov, P., Bechara, R., Schiavone, G., Le, J., Madaka, P., Kawaguti, F., Moura, R., Khalaf, M., King, W., Northern, N., Al-Shamali, H., Dang, F., Samarasena, J., Joseph, A., Friedland, S., Hwang, J., Li, A., Tomizawa, Y., Lucaciu, L., Subramanian, R., Despott, E., Ngamruengphong, S. MOSBY-ELSEVIER. 2024: AB469-AB470

  View details for Web of Science ID 001278323001422

• OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL ESOPHAGEAL SQUAMOUS NEOPLASMS: A MULTICENTER NORTH AMERICAN EXPERIENCE Subrahmanyan, R., Almario, J., Aihara, H., Kumar, A., Schlachterman, A., Friedland, S., Hwang, J., Othman, M., Jawaid, S., Ferri, L., Teshima, C., Mosko, J., Bechara, R., Samarasena, J., Yang, D., Ujiki, M., Tomizawa, Y., Schiavone, G., Madaka, P., Joseph, A., Li, A., Khalaf, M., Qatomah, A., Al-Shamali, H., Dang, F., Tavangar, A., Rwigema, J., King, W., Northern, N., Draganov, P., Ngamruengphong, S. MOSBY-ELSEVIER. 2024: AB992-AB993

  View details for Web of Science ID 001278323004037

• Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 LANCET NEUROLOGY Steinmetz, J. D., Seeher, K., Schiess, N., Nichols, E., Cao, B., Servili, C., Cavallera, V., Cousin, E., Hagins, H., Moberg, M. E., Mehlman, M. L., Abate, Y., Abbas, J., Abbasi, M., Abbasian, M., Abbastabar, H., Abdelmasseh, M., Abdollahi, M., Abdollahi, M., Abdollahifar, M., Abd-Rabu, R., Abdulah, D., Abdullahi, A., Abedi, A., Abedi, V., Zuniga, R., Abidi, H., Abiodun, O., Aboagye, R., Abolhassani, H., Aboyans, V., Abrha, W., Abualhasan, A., Abu-Gharbieh, E., Aburuz, S., Adamu, L., Addo, I., Adebayo, O. M., Adekanmbi, V., Adekiya, T., Adikusuma, W., Adnani, Q., Adra, S., Afework, T., Afolabi, A., Afraz, A., Afzal, S., Aghamiri, S., Agodi, A., Agyemang-Duah, W., Ahinkorah, B., Ahmad, A., Ahmad, D., Ahmad, S., Ahmadzade, A., Ahmed, A., Ahmed, A., Ahmed, H., Ahmed, J., Ahmed, L. A., Ahmed, M., Ahmed, S., Ajami, M., Aji, B., Ajumobi, O., Akade, S., Akbari, M., Akbarialiabad, H., Akhlaghi, S., Akinosoglou, K., Akinyemi, R., Akonde, M., Al Hasan, S., Alahdab, F., Al-Ahdal, T., Al-Amer, R., Albashtawy, M., AlBataineh, M. T., Aldawsari, K. A., Alemi, H., Alemi, S., Algammal, A. M., Al-Gheethi, A., Alhalaiqa, F., Alhassan, R., Ali, A., Ali, E., Ali, L., Ali, M., Ali, M., Ali, R., Ali, S., Ali, S., Ali, Z., Alif, S., Alimohamadi, Y., Aliyi, A., Aljofan, M., Aljunid, S., Alladi, S., Almazan, J., Almustanyir, S., Al-Omari, B., Alqahtani, J. S., Alqasmi, I., Alqutaibi, A., Salman, R., Altaany, Z., Al-Tawfiq, J. A., Altirkawi, K. A., Alvis-Guzman, N., Al-Worafi, Y., Aly, H., Aly, S., Alzoubi, K. H., Amani, R., Amindarolzarbi, A., Amiri, S., Amirzade-Iranaq, M., Amu, H., Amugsi, D. A., Amusa, G., Amzat, J., Ancuceanu, R., Anderlini, D., Anderson, D. B., Andrei, C., Androudi, S., Angappan, D., Angesom, T. W., Anil, A., Ansari-Moghaddam, A., Anwer, R., Arafat, M., Aravkin, A. Y., Areda, D., Ariffin, H., Arifin, H., Arkew, M., Arnlov, J., Arooj, M., Artamonov, A. A., Artanti, K., Aruleba, R., Asadi-Pooya, A. A., Asena, T., Asghari-Jafarabadi, M., Ashraf, M., Ashraf, T., Atalell, K., Athari, S., Atinafu, B., Atorkey, P., Atout, M., Atreya, A., Aujayeb, A., Avan, A., Quintanilla, B., Ayatollahi, H., Ayinde, O. O., Ayyoubzadeh, S., Azadnajafabad, S., Azizi, Z., Azizian, K., Azzam, A. Y., Babaei, M., Badar, M., Badiye, A. D., Baghdadi, S., Bagherieh, S., Bai, R., Baig, A., Balakrishnan, S., Balalla, S., Baltatu, O., Banach, M., Bandyopadhyay, S., Banerjee, I., Baran, M., Barboza, M. A., Barchitta, M., Bardhan, M., Barker-Collo, S., Barnighausen, T., Barrow, A., Bashash, D., Bashiri, H., Bashiru, H., Basiru, A., Basso, J., Basu, S., Batiha, A., Batra, K., Baune, B. T., Bedi, N., Begde, A., Begum, T., Behnam, B., Behnoush, A., Beiranvand, M., Bejot, Y., Bekele, A., Belete, M., Belgaumi, U., Bemanalizadeh, M., Bender, R. G., Benfor, B., Bennett, D. A., Bensenor, I. M., Berice, B., Bettencourt, P. G., Beyene, K. A., Bhadra, A., Bhagat, D. S., Bhangdia, K., Bhardwaj, N., Bhardwaj, P., Bhargava, A., Bhaskar, S., Bhat, A., Bhat, V., Bhatti, G., Bhatti, J., Bhatti, R., Bijani, A., Bikbov, B., Bilalaga, M., Biswas, A., Bitaraf, S., Bitra, V. R., Bjorge, T., Bodolica, V., Bodunrin, A., Boloor, A., Braithwaite, D., Brayne, C., Brenner, H., Briko, A., Vega, M., Brown, J., Budke, C. M., Buonsenso, D., Burkart, K., Burns, R. A., Bustanji, Y., Butt, M., Butt, N., Butt, Z. A., Cabral, L., dos Santos, F., Calina, D., Campos-Nonato, I. R., Cao, C., Carabin, H., Cardenas, R., Carreras, G., Carvalho, A. F., Castaneda-Orjuela, C. A., Casulli, A., Catala-Lopez, F., Catapano, A. L., Caye, A., Cegolon, L., Cenderadewi, M., Cerin, E., Chacon-Uscamaita, P., Chan, J., Chanie, G., Charan, J., Chattu, V., Abebe, E., Chen, H., Chen, J., Chi, G., Chichagi, F., Chidambaram, S., Chimoriya, R., Ching, P. R., Chitheer, A., Chong, Y., Chopra, H., Choudhari, S., Chowdhury, E., Chowdhury, R., Christensen, H., Chu, D., Chukwu, I., Chung, E., Coberly, K., Columbus, A., Comachio, J., Conde, J., Cortesi, P., Costa, V., Couto, R. S., Criqui, M. H., Cruz-Martins, N., Ohadi, M., Dadana, S., Dadras, O., Dai, X., Dai, Z., D'Amico, E., Danawi, H. A., Dandona, L., Dandona, R., Darwish, A., Das, S., Das, S., Dascalu, A., Dash, N., Dashti, M., De la Hoz, F., de la Torre-Luque, A., De Leo, D., Dean, F. E., Dehghan, A., Dehghan, A., Dejene, H., Demant, D., Demetriades, A. K., Demissie, S., Deng, X., Desai, H., Devanbu, V., Dhama, K., Dharmaratne, S., Dhimal, M., da Silva, D., Diaz, D., Dibas, M., Ding, D. D., Dinu, M., Dirac, M., Diress, M., Thanh Chi Do, Thao Huynh Phuong Do, Khanh Duy Khanh Doan, Dodangeh, M., Doheim, M., Dokova, K., Dongarwar, D., Dsouza, H., Dube, J., Duraisamy, S., Durojaiye, O., Dutta, S., Dziedzic, A., Edinur, H., Eissazade, N., Ekholuenetale, M., Ekundayo, T., El Nahas, N., El Sayed, I., Najafi, M., Elbarazi, I., Elemam, N., Elgar, F. J., Elgendy, I. Y., Elhabashy, H., Elhadi, M., Elilo, L., Ellenbogen, R. G., Elmeligy, O., Elmonem, M. A., Elshaer, M., Elsohaby, I., Emamverdi, M., Emeto, T. I., Endres, M., Esezobor, C., Eskandarieh, S., Fadaei, A., Fagbamigbe, A., Fahim, A., Faramarzi, A., Fares, J., Kouhanjani, M., Faro, A., Farzadfar, F., Fatehizadeh, A., Fathi, M., Fathi, S., Fatima, S., Feizkhah, A., Fereshtehnejad, S., Ferrari, A. J., Ferreira, N., Fetensa, G., Firouraghi, N., Fischer, F., Fonseca, A., Force, L. M., Fornari, A., Foroutan, B., Fukumoto, T., Gadanya, M. A., Gaidhane, A., Galali, Y., Galehdar, N., Gan, Q., Gandhi, A. P., Ganesan, B., Gardner, W. M., Garg, N., Gau, S., Gautam, R. K., Gebre, T., Gebrehiwot, M., Gebremeskel, G., Gebreslassie, H., Getacher, L., Yazdi, B., Ghadirian, F., Ghaffarpasand, F., Ghanbari, R., Ghasemi, M., Ghazy, R., Ghimire, S., Gholami, A., Gholamrezanezhad, A., Ghotbi, E., Ghozy, S., Gialluisi, A., Gill, P., Glasstetter, L. M., Gnedovskaya, E. V., Golchin, A., Golechha, M., Goleij, P., Golinelli, D., Gomes-Neto, M., Goulart, A. C., Goyal, A., Gray, R. J., Grivna, M., Guadie, H., Guan, B., Guarducci, G., Guicciardi, S., Gunawardane, D., Guo, H., Gupta, B., Gupta, R., Gupta, S., Gupta, V., Gupta, V., Gutierrez, R., Habibzadeh, F., Hachinski, V., Haddadi, R., Hadei, M., Hadi, N. R., Haep, N., Haile, T., Haj-Mirzaian, A., Hall, B. J., Halwani, R., Hameed, S., Hamiduzzaman, M., Hammoud, A., Han, H., Hanifi, N., Hankey, G. J., Hannan, M., Hao, J., Harapan, H., Hareru, H., Hargono, A., Harlianto, N. I., Haro, J., Hartman, N., Hasaballah, A. 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  Abstract

  Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.We estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378-521), affecting 3·40 billion (3·20-3·62) individuals (43·1%, 40·5-45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7-26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6-38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5-32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7-2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed.Bill & Melinda Gates Foundation.

  View details for DOI 10.1016/S1474-4422(24)00038-3

  View details for Web of Science ID 001270049900001

  View details for PubMedID 38493795

  View details for PubMedCentralID PMC10949203

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M., Tamuzi, J., Tan, K., Tat, N. Y., Oliaee, R., Tavasol, A., Temsah, M., Thangaraju, P., Tharwat, S., Tibebu, N., Ticoalu, J., Tillawi, T., Tiruye, T., Tiyuri, A., Tovani-Palone, M., Tripathi, M., Tsegay, G., Tualeka, A., Ty, S., Ubah, C. S., Ullah, S., Ullah, S., Umair, M., Umakanthan, S., Upadhyay, E., Vahabi, S., Vaithinathan, A., Tahbaz, S., Valizadeh, R., Varthya, S., Vasankari, T., Venketasubramanian, N., Verras, G., Villafane, J., Vlassov, V., Danh Cao Vo, Waheed, Y., Waris, A., Welegebrial, B., Westerman, R., Wickramasinghe, D., Wickramasinghe, N., Willekens, B., Woldegeorgis, B., Woldemariam, M., Xiao, H., Yada, D. Y., Yahya, G., Yang, L., Yazdanpanah, F., Yon, D., Yonemoto, N., You, Y., Zahir, M., Zaidi, S., Zangiabadian, M., Zare, I., Zeineddine, M. A., Zemedikun, D. T., Zeru, N., Zhang, C., Zhao, H., Zhong, C., Zielinska, M., Zoladl, M., Zumla, A., Guo, C., Tam, L., GBD 2019 IMID Collaborators 2023; 64: 102193

  Abstract

  The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019.We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends.In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of -0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = -0.41), inflammatory bowel disease (AAPC = -0.72), multiple sclerosis (AAPC = -0.26), psoriasis (AAPC = -0.77), and atopic dermatitis (AAPC = -0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR.The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively.The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38).

  View details for DOI 10.1016/j.eclinm.2023.102193

  View details for Web of Science ID 001084747100001

  View details for PubMedID 37731935

  View details for PubMedCentralID PMC10507198

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  Abstract

  Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050.Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively.In 2021, there were 529 million (95% uncertainty interval [UI] 500-564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8-6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7-9·9]) and, at the regional level, in Oceania (12·3% [11·5-13·0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1-79·5) in individuals aged 75-79 years. Total diabetes prevalence-especially among older adults-primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1-96·8) of diabetes cases and 95·4% (94·9-95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5-71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5-30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22-1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1-17·6) in north Africa and the Middle East and 11·3% (10·8-11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%.Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers.Bill & Melinda Gates Foundation.

  View details for DOI 10.1016/S0140-6736(23)01301-6

  View details for Web of Science ID 001084390700001

  View details for PubMedID 37356446

  View details for PubMedCentralID PMC10364581

• ENDOSCOPIC SUBMUCOSAL DISSECTION OF ESOPHAGEAL ADENOCARCINOMA DEEMED PATHOLOGICALLY CURATIVE RESULTS IN FEW RECURRENCES AT LONG-TERM SURVEILLANCE: A NORTH AMERICAN STUDY Schenck, R., Bhatt, A., Ngamruengphong, S., Friedland, S., Aihara, H., Dewitt, J., Patrie, J., Foster, S., Joseph, A., Arayakarnkul, S., Mercado, M., Northern, N., Aadam, A., Othman, M., Sethi, A., Sharaiha, R., Nishimura, M., Fukami, N., Hwang, J., Yang, D., Draganov, P., Wang, A. MOSBY-ELSEVIER. 2023: AB1105-AB1106

  View details for Web of Science ID 001038022802459

• ENDOSCOPIC SUBMUCOSAL DISSECTION OF ESOPHAGEAL ADENOCARCINOMA DEEMED PATHOLOGICALLY CURATIVE RESULTS IN FEW RECURRENCES AT LONG-TERM SURVEILLANCE: A NORTH AMERICAN STUDY Schenck, R., Bhatt, A., Ngamruengphong, S., Friedland, S., Aihara, H., Dewitt, J., Patrie, J., Foster, S., Joseph, A., Arayakarnkul, S., Mercado, M., Northern, N., Aadam, A., Othman, M., Sethi, A., Sharaiha, R., Nishimura, M., Fukami, N., Hwang, J., Yang, D., Draganov, P., Wang, A. MOSBY-ELSEVIER. 2023: AB1018-AB1019

  View details for Web of Science ID 001038022802336

• OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR PREVIOUSLY ATTEMPTED COLORECTAL LESIONS: AN INTERNATIONAL MULTICENTER EXPERIENCE Arayakarnkul, S., Aihara, H., Repici, A., Da Rio, L., Maselli, R., Capogreco, A., Kawaguti, F., Maluf-Filho, F., Friedland, S., Bechara, R., Mohapatra, S., Fukami, N., Joseph, A., Bhatt, A., Schlachterman, A., Kumar, A., Wang, A., Buerlein, R., Song, L., Deepali, F., Hasan, M., Yang, D., Kumta, N., Diehl, D., Rimondi, A., Lucaciu, L., Despott, E., Sharaiha, R., Mahadev, S., Hassan, K., Abu-Hammour, M., Kumbhari, V., Park, J., Robles-Medranda, C., Arevalo-Mora, M., Alcivar-Vasquez, J., Jawaid, S., Khalaf, M., Al Ghamdi, S., Othman, M., Ngamruengphong, S. MOSBY-ELSEVIER. 2023: AB430-AB431

  View details for Web of Science ID 001038022801059

• Initial Multicenter Experience of Traction Wire Endoscopic Submucosal Dissection TECHNIQUES AND INNOVATIONS IN GASTROINTESTINAL ENDOSCOPY Joseph, A., Kahaleh, M., Li, A. A., Haber, G. B., Kedia, P., Makiguchi, M., Sharma, N. R., Ha Hwang, J., Chak, A., Al-Taee, A. M., Braun, D., Mok, S., Mehta, N. A., Gorgun, E., Vargo, J., Abe, S., Saito, Y., Stevens, T., Bhatt, A. 2023; 25 (1): 21-29

  View details for DOI 10.1016/j.tige.2022.10.002

  View details for Web of Science ID 001035713900001