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  • Histologic Activity from Neoterminal Ileal Biopsies in Patients with Crohn's Disease in Endoscopic Remission is Associated with Postoperative Recurrence. The American journal of gastroenterology Shah, R. S., Hu, J. H., Bachour, S., Joseph, A., Syed, H., Yang, Q., Ali, A. H., Li, T., Contreras, S., Pothula, S., Vinaithirthan, V., Regueiro, M., Axelrad, J., Barnes, E. L., Cohen, B. L., Click, B. H. 2024

    Abstract

    Following ileocolic resection (ICR), the clinical importance and prognostic implications of histologic activity on biopsies in Crohn's disease (CD) patients with endoscopic remission are not well defined. This study aimed to determine if histologic activity in patients with endoscopic remission is associated with future risk of endoscopic and/or radiologic postoperative recurrence (POR).In this multicenter retrospective cohort study, adult patients with CD who underwent ICR between 2009-2020 with endoscopic biopsies of ileal mucosa from Rutgeerts' i0 on index colonoscopy were included. The composite rate of endoscopic (Rutgeerts' score≥i2b) and radiologic (active inflammation on imaging) recurrence was compared in patients with and without histologic activity using a Kaplan-Meier survival analysis. A multivariable Cox proportional hazard regression model including clinically relevant risk factors for POR, postoperative biologic prophylaxis, and histology activity was designed.A total of 113 patients with i0 disease on index colonoscopy after ICR were included. Of these, 42% had histologic activity. Time to POR was significantly earlier in the histologically active versus normal group (p=0.04). After adjusting for clinical risk factors for POR, histologic activity (HR 2.37, 95% CI 1.17-4.79; p=0.02) and active smoking (HR 2.54, 95% CI 1.02-6.33; p=0.05) were independently associated with subsequent composite POR risk.In patients with postoperative CD, histologic activity despite complete endoscopic remission is associated with composite, endoscopic and radiographic, recurrence. Further understanding of the role of histologic activity in patients with Rutgeerts' i0 disease may provide a novel target to reduce disease recurrence in this population.

    View details for DOI 10.14309/ajg.0000000000002963

    View details for PubMedID 39007494

  • OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL ESOPHAGEAL SQUAMOUS NEOPLASMS: A MULTICENTER NORTH AMERICAN EXPERIENCE Subrahmanyan, R., Almario, J., Aihara, H., Kumar, A., Schlachterman, A., Friedland, S., Hwang, J., Othman, M., Jawaid, S., Ferri, L., Teshima, C., Mosko, J., Bechara, R., Samarasena, J., Yang, D., Ujiki, M., Tomizawa, Y., Schiavone, G., Madaka, P., Joseph, A., Li, A., Khalaf, M., Qatomah, A., Al-Shamali, H., Dang, F., Tavangar, A., Rwigema, J., King, W., Northern, N., Draganov, P., Ngamruengphong, S. MOSBY-ELSEVIER. 2024: AB1068-AB1069

    View details for Web of Science ID 001278323004174

  • OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL ESOPHAGEAL SQUAMOUS NEOPLASMS: A MULTICENTER NORTH AMERICAN EXPERIENCE Subrahmanyan, R., Almario, J., Aihara, H., Kumar, A., Schlachterman, A., Friedland, S., Hwang, J., Othman, M., Jawaid, S., Ferri, L., Teshima, C., Mosko, J., Bechara, R., Samarasena, J., Yang, D., Ujiki, M., Tomizawa, Y., Schiavone, G., Madaka, P., Joseph, A., Li, A., Khalaf, M., Qatomah, A., Al-Shamali, H., Dang, F., Tavangar, A., Rwigema, J., King, W., Northern, N., Draganov, P., Ngamruengphong, S. MOSBY-ELSEVIER. 2024: AB992-AB993

    View details for Web of Science ID 001278323004037

  • LONG TERM OUTCOMES OF NON-CURATIVE ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL LESIONS Almario, J., Hiroyuki, A., Kumar, A., Schlachterman, A., Maluf-Filho, F., Othman, M., Jawaid, S., Teshima, C., Mosko, J., Draganov, P., Bechara, R., Schiavone, G., Le, J., Madaka, P., Kawaguti, F., Moura, R., Khalaf, M., King, W., Northern, N., Al-Shamali, H., Dang, F., Samarasena, J., Joseph, A., Friedland, S., Hwang, J., Li, A., Tomizawa, Y., Lucaciu, L., Subramanian, R., Despott, E., Ngamruengphong, S. MOSBY-ELSEVIER. 2024: AB469-AB470

    View details for Web of Science ID 001278323001422

  • Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019 ECLINICALMEDICINE Wu, D., Jin, Y., Xing, Y., Abate, M., Abbasian, M., Abbasi-Kangevari, M., Abbasi-Kangevari, Z., Abd-Allah, F., Abdelmasseh, M., Abdollahifar, M., Abdulah, D., Abedi, A., Abedi, V., Abidi, H., Aboagye, R., Abolhassani, H., Abuabara, K., Abyadeh, M., Addo, I., Adeniji, K., Adepoju, A., Adesina, M., Adnani, Q., Afarideh, M., Aghamiri, S., Agodi, A., Agrawal, A., Aguilera Arriagada, C., Ahmad, A., Ahmad, D., Ahmad, S., Ahmad, S., Ahmadi, A., Ahmed, A., Ahmed, A., Aithala, J. P., Ajadi, A., Ajami, M., Akbarzadeh-Khiavi, M., Alahdab, F., AlBataineh, M. T., Alemi, S., Al-Gheethi, A., Ali, L., Alif, S., Almazan, J., Almustanyir, S., Alqahtani, J. S., Alqasmi, I., Altaf, I., Alvis-Guzman, N., Alvis-Zakzuk, N. J., Al-Worafi, Y., Aly, H., Amani, R., Amu, H., Amusa, G., Andrei, C., Ansar, A., Ansariniya, H., Anyasodor, A., Arabloo, J., Arefnezhad, R., Arulappan, J., Asghari-Jafarabadi, M., Ashraf, T., Atata, J., Athari, S., Atlaw, D., Atout, M., Aujayeb, A., Awan, A., Ayatollahi, H., Azadnajafabad, S., Azzam, A. Y., Badawi, A., Badiye, A. D., Bagherieh, S., Baig, A., Bantie, B., Barchitta, M., Bardhan, M., Barker-Collo, S., Barone-Adesi, F., Batra, K., Bayileyegn, N., Behnoush, A., Belgaumi, U., Bemanalizadeh, M., Bensenor, I. M., Beyene, K. A., Bhagavathula, A., Bhardwaj, P., Bhaskar, S., Bhat, A., Bitaraf, S., Bitra, V. R., Boloor, A., Bora, K., Botelho, J., Buchbinder, R., Calina, D., Alberto Camera, L., Carvalho, A. F., Chan, J., Chattu, V., Abebe, E., Chichagi, F., Choi, S., Chou, T., Chu, D., Coberly, K., Costa, V., Couto, R. S., Cruz-Martins, N., Dadras, O., Dai, X., Damiani, G., Dascalu, A., Dashti, M., Debela, S., Dellavalle, R., Demetriades, A. K., Demlash, A., Deng, X., Desai, H., Desai, R., Dewan, S., Dey, S., Dharmaratne, S., Diaz, D., Dibas, M., Dinis-Oliveira, R., Diress, M., Thanh Chi Do, Doan, D., Dodangeh, M., Dodangeh, M., Dongarwar, D., Dube, J., Dziedzic, A., Ed-Dra, A., Edinur, H., Eissazade, N., Ekholuenetale, M., Ekundayo, T., Elemam, N., Elhadi, M., Elmehrath, A. O., Elmeligy, O., Emamverdi, M., Emeto, T. I., Esayas, H., Eshetu, H., Etaee, F., Fagbamigbe, A., Faghani, S., Fakhradiyev, I., Fatehizadeh, A., Fathi, M., Feizkhah, A., Fekadu, G., Fereidouni, M., Fereshtehnejad, S., Fernandes, J. C., Ferrara, P., Fetensa, G., Filip, I., Fischer, F., Foroutan, B., Foroutan, M., Fukumoto, T., Ganesan, B., Gemeda, B., Ghamari, S., Ghasemi, M., Gholamalizadeh, M., Gill, T. K., Gillum, R. F., Goldust, M., Golechha, M., Goleij, P., Golinelli, D., Goudarzi, H., Guan, S., Guo, Y., Gupta, B., Gupta, V., Gupta, V., Haddadi, R., Hadi, N. R., Halwani, R., Haque, S., Hasan, I., Hashempour, R., Hassan, A., Hassan, T. S., Hassanzadeh, S., Hassen, M., Haubold, J., Hayat, K., Heidari, G., Heidari, M., Heidari-Soureshjani, R., Herteliu, C., Hessami, K., Hezam, K., Hiraike, Y., Holla, R., Hosseini, M., Huynh, H., Hwang, B., Ibitoye, S., Ilic, I. M., Ilic, M. D., Iranmehr, A., Iravanpour, F., Ismail, N., Iwagami, M., Iwu, C. D., Jacob, L., Jafarinia, M., Jafarzadeh, A., Jahankhani, K., Jahrami, H., Jakovljevic, M., Jamshidi, E., Jani, C. T., Janodia, M., Jayapal, S., Jayaram, S., Jeganathan, J., Jonas, J. B., Joseph, A., Joseph, N., Joshua, C., Vaishali, K., Kaambwa, B., Kabir, A., Kabir, Z., Kadashetti, V., Kaliyadan, F., Kalroozi, F., Kamal, V., Kandel, A., Kandel, H., Kanungo, S., Karami, J., Karaye, I. M., Karimi, H., Kasraei, H., Kazemian, S., Kebede, S., Keikavoosi-Arani, L., Keykhaei, M., Khader, Y., Khajuria, H., Khamesipour, F., Khan, E., Khan, I. A., Khan, M., Khan, M., Ab Khan, M., Khan, M., Khatatbeh, H., Khatatbeh, M., Khateri, S., Kashani, H., Kim, M., Kisa, A., Kisa, S., Koh, H., Kolkhir, P., Korzh, O., Kotnis, A., Koul, P. A., Koyanagi, A., Krishan, K., Kuddus, M., Kulkarni, V., Kumar, N., Kundu, S., Kurmi, O. P., La Vecchia, C., Lahariya, C., Laksono, T., Lam, J., Latief, K., Lauriola, P., Lawal, B., Thao Thi Thu Le, Trang Thi Bich Le, Lee, M., Lee, S., Lee, W., Lee, Y., Lenzi, J., Levi, M., Li, W., Ligade, V. S., Lim, S. S., Liu, G., Liu, X., Llanaj, E., Lo, C., Machado, V., Maghazachi, A. A., Mahmoud, M., Mai, T. A., Majeed, A., Sanaye, P., Makram, O., Rad, E., Malhotra, K., Malik, A., Malik, I., Mallhi, T., Malta, D., Mansournia, M., Mantovani, L., Martorell, M., Masoudi, S., Masoumi, S., Mathangasinghe, Y., Mathews, E., Mathioudakis, A. G., Maugeri, A., Mayeli, M., Medina, J., Meles, G., Mendes, J., Menezes, R. G., Mestrovic, T., Michalek, I., Micheletti Gomide Nogueira de Sa, A., Mihretie, E., Minh, L., Mirfakhraie, R., Mirrakhimov, E. M., Misganaw, A., Mohamadkhani, A., Mohamed, N., Mohammadi, F., Mohammadi, S., Mohammed, S., Mohammed, S., Mohan, S., Mohseni, A., Mokdad, A. H., Momtazmanesh, S., Monasta, L., Moni, M., Moniruzzaman, M., Moradi, Y., Morovatdar, N., Mostafavi, E., Mousavi, P., Mukoro, G., Mulita, A., Mulu, G., Murillo-Zamora, E., Musaigwa, F., Mustafa, G., Muthu, S., Nainu, F., Nangia, V., Swamy, S., Natto, Z. S., Navaraj, P., Nayak, B., Nazri-Panjaki, A., Negash, H., Nematollahi, M., Nguyen, D. H., Hau Thi Hien Nguyen, Hien Quang Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Niazi, R., Nikolouzakis, T., Nnyanzi, L., Noreen, M., Nzoputam, C., Nzoputam, O., Oancea, B., Oh, I., Okati-Aliabad, H., Okonji, O., Okwute, P., Olagunju, A. T., Olatubi, M., Olufadewa, I., Ordak, M., Otstavnov, N., Owolabi, M. O., Mahesh, P. A., Padubidri, J., Pak, A., Pakzad, R., Palladino, R., Pana, A., Pantazopoulos, I., Papadopoulou, P., Pardhan, S., Parthasarathi, A., Pashaei, A., Patel, J., Pathan, A., Patil, S., Paudel, U., Pawar, S., Pedersini, P., Pensato, U., Pereira, D. M., Pereira, J., Pereira, M., Pereira, R. B., Peres, M. P., Perianayagam, A., Perna, S., Petcu, I., Pezeshki, P., Hoang Tran Pham, Philip, A. K., Piradov, M. A., Podder, I., Podder, V., Poddighe, D., Prates, E., Qattea, I., Radfar, A., Raee, P., Rafiei, A., Raggi, A., Rahim, F., Rahimi, M., Rahimifard, M., Rahimi-Movaghar, V., Rahman, M., Rahman, M., Rahman, M., Rahman, M., Rahmani, A., Rahmani, M., Rahmani, S., Rahmanian, V., Ramasubramani, P., Rancic, N., Rao, I., Rashedi, S., Rashid, A., Ravikumar, N., Rawaf, S., Redwan, E., Rezaei, N., Rezaei, N., Rezaei, N., Rezaeian, M., Ribeiro, D., Rodrigues, M., Buendia Rodriguez, J., Roever, L., Romero-Rodriguez, E., Saad, A. A., Saddik, B., Sadeghian, S., Saeed, U., Safary, A., Safdarian, M., Safi, S., Saghazadeh, A., Sagoe, D., Sharif-Askari, F., Sharif-Askari, N., Sahebkar, A., Sahoo, H., Sahraian, M., Sajid, M., Sakhamuri, S., Sakshaug, J. W., Saleh, M. A., Salehi, L., Salehi, S., Farrokhi, A., Samadzadeh, S., Samargandy, S., Samieefar, N., Samy, A. M., Sanadgol, N., Sanjeev, R., Sawhney, M., Saya, G., Schuermans, A., Senthilkumaran, S., Sepanlou, S. G., Sethi, Y., Shafie, M., Shah, H., Shahid, I., Shahid, S., Shaikh, M., Sharfaei, S., Sharma, M., Shayan, M., Shehata, H., Sheikh, A., Shetty, J. K., Shin, J., Shirkoohi, R., Shitaye, N., Shivakumar, K. M., Shivarov, V., Shobeiri, P., Siabani, S., Sibhat, M., Siddig, E., Simpson, C. R., Sinaei, E., Singh, H., Singh, I., Singh, J. A., Singh, P., Singh, S., Siraj, M., Sohag, A., Solanki, R., Solikhah, S., Solomon, Y., Soltani-Zangbar, M., Sun, J., Szeto, M. D., Tabares-Seisdedos, R., Tabatabaei, S., Tabish, M., Taheri, E., Tahvildari, A., Talaat, I. M., Tamuzi, J., Tan, K., Tat, N. Y., Oliaee, R., Tavasol, A., Temsah, M., Thangaraju, P., Tharwat, S., Tibebu, N., Ticoalu, J., Tillawi, T., Tiruye, T., Tiyuri, A., Tovani-Palone, M., Tripathi, M., Tsegay, G., Tualeka, A., Ty, S., Ubah, C. S., Ullah, S., Ullah, S., Umair, M., Umakanthan, S., Upadhyay, E., Vahabi, S., Vaithinathan, A., Tahbaz, S., Valizadeh, R., Varthya, S., Vasankari, T., Venketasubramanian, N., Verras, G., Villafane, J., Vlassov, V., Danh Cao Vo, Waheed, Y., Waris, A., Welegebrial, B., Westerman, R., Wickramasinghe, D., Wickramasinghe, N., Willekens, B., Woldegeorgis, B., Woldemariam, M., Xiao, H., Yada, D. Y., Yahya, G., Yang, L., Yazdanpanah, F., Yon, D., Yonemoto, N., You, Y., Zahir, M., Zaidi, S., Zangiabadian, M., Zare, I., Zeineddine, M. A., Zemedikun, D. T., Zeru, N., Zhang, C., Zhao, H., Zhong, C., Zielinska, M., Zoladl, M., Zumla, A., Guo, C., Tam, L., GBD 2019 IMID Collaborators 2023; 64: 102193

    Abstract

    The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019.We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends.In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of -0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = -0.41), inflammatory bowel disease (AAPC = -0.72), multiple sclerosis (AAPC = -0.26), psoriasis (AAPC = -0.77), and atopic dermatitis (AAPC = -0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR.The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively.The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38).

    View details for DOI 10.1016/j.eclinm.2023.102193

    View details for Web of Science ID 001084747100001

    View details for PubMedID 37731935

    View details for PubMedCentralID PMC10507198

  • Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 LANCET Ong, K., Stafford, L. K., Mclaughlin, S. A., Boyko, E. J., Vollset, S., Smith, A. E., Dalton, B. E., Duprey, J., Cruz, J. A., Hagins, H., Lindstedt, P. A., Aali, A., Abate, Y., Abate, M., Abbasian, M., Abbasi-Kangevari, Z., Abbasi-Kangevari, M., Abd ElHafeez, S., Abd-Rabu, R., Abdulah, D., Abdullah, A., Abedi, V., Abidi, H., Aboagye, R., Abolhassani, H., Abu-Gharbieh, E., Abu-Zaid, A., Adane, T., Adane, D., Addo, I., Adegboye, O. A., Adekanmbi, V., Adepoju, A., Adnani, Q., Afolabi, R., Agarwal, G., Aghdam, Z., Agudelo-Botero, M., Arriagada, C., Agyemang-Duah, W., Ahinkorah, B., Ahmad, D., Ahmad, R., Ahmad, S., Ahmad, A., Ahmadi, A., Ahmadi, K., Ahmed, A., Ahmed, A., Ahmed, L. A., Ahmed, S., Ajami, M., Akinyemi, R., Al Hamad, H., Hasan, S., AL-Ahdal, T., Alalwan, T. A., Al-Aly, Z., Albataineh, M., Alcalde-Rabanal, J., Alemi, S., Ali, H., Alinia, T., Aljunid, S., Almustanyir, S., Al-Raddadi, R. M., Alvis-Guzman, N., Amare, F., Ameyaw, E., Amiri, S., Amusa, G., Andrei, C., Anjana, R., Ansar, A., Ansari, G., Ansari-Moghaddam, A., Anyasodor, A., Arabloo, J., Aravkin, A. Y., Areda, D., Arifin, H., Arkew, M., Armocida, B., Aernloev, J., Artamonov, A. A., Arulappan, J., Aruleba, R., Arumugam, A., Aryan, Z., Asemu, M., Asghari-Jafarabadi, M., Askari, E., Asmelash, D., Astell-Burt, T., Athar, M., Athari, S., Atout, M., Avila-Burgos, L., Awaisu, A., Azadnajafabad, S., Babamohamadi, H., Badar, M., Badawi, A., Badiye, A., Baghcheghi, N., Bagheri, N., Bagherieh, S., Bah, S., Bahadory, S., Bai, R., Baig, A., Baltatu, O., Baradaran, H., Barchitta, M., Bardhan, M., Barengo, N. C., Baernighausen, T., Barone, M., Barone-Adesi, F., Barrow, A., Bashiri, H., Basiru, A., Basu, S., Basu, S., Batiha, A., Batra, K., Bayih, M., Bayileyegn, N., Behnoush, A., Bekele, A., Belete, M., Belgaumi, U., Belo, L., Bennett, D. A., Bensenor, I. M., Berhe, K., Berhie, A., Bhaskar, S., Bhat, A., Bhatti, J., Bikbov, B., Bilal, F., Bintoro, B., Bitaraf, S., Bitra, V. R., Bjegovic-Mikanovic, V., Bodolica, V., Boloor, A., Brauer, M., Brazo-Sayavera, J., Brenner, H., Butt, Z. A., Calina, D., Campos, L., Campos-Nonato, I. R., Cao, Y., Cao, C., Car, J., Carvalho, M., Castaneda-Orjuela, C. A., Catala-Lopez, F., Cerin, E., Chadwick, J., Chandrasekar, E. K., Chanie, G., Charan, J., Chattu, V., Chauhan, K., Cheema, H., Abebe, E., Chen, S., Cherbuin, N., Chichagi, F., Chidambaram, S., Cho, W. S., Choudhari, S., Chowdhury, R., Chowdhury, E., Chu, D., Chukwu, I., Chung, S., Coberly, K., Columbus, A., Contreras, D., Cousin, E., Criqui, M. H., Cruz-Martins, N., Cuschieri, S., Dabo, B., Dadras, O., Dai, X., Damasceno, A., Dandona, R., Dandona, L., Das, S., Dascalu, A., Dash, N., Dashti, M., Davila-Cervantes, C., Cruz-Gongora, V., Debele, G., Delpasand, K., Demisse, F., Demissie, G., Deng, X., Denova-Gutierrez, E., Deo, S., Dervisevic, E., Desai, H., Desale, A., Dessie, A., Desta, F., Dewan, S., Dey, S., Dhama, K., Dhimal, M., Diao, N., Diaz, D., Dinu, M., Diress, M., Djalalinia, S., Doan, L., Dongarwar, D., Figueiredo, F., Duncan, B. B., Dutta, S., Dziedzic, A., Edinur, H., Ekholuenetale, M., Ekundayo, T., Elgendy, I. Y., Elhadi, M., El-Huneidi, W., Elmeligy, O., Elmonem, M. A., Endeshaw, D., Esayas, H., Eshetu, H., Etaee, F., Fadhil, I., Fagbamigbe, A., Fahim, A., Falahi, S., Faris, M., Farrokhpour, H., Farzadfar, F., Fatehizadeh, A., Fazli, G., Feng, X., Ferede, T. Y., Fischer, F., Flood, D., Forouhari, A., Foroumadi, R., Koudehi, M., Gaidhane, A., Gaihre, S., Gaipov, A., Galali, Y., Ganesan, B., Garcia-Gordillo, M. A., Gautam, R. K., Gebrehiwot, M., Gebrekidan, K., Gebremeskel, T., Getacher, L., Ghadirian, F., Ghamari, S., Nour, M., Ghassemi, F., Golechha, M., Goleij, P., Golinelli, D., Gopalani, S., Guadie, H., Guan, S., Gudayu, T., Guimaraes, R., Guled, R., Gupta, R., Gupta, K., Gupta, V., Gupta, V., Gyawali, B., Haddadi, R., Hadi, N. R., Haile, T., Hajibeygi, R., Haj-Mirzaian, A., Halwani, R., Hamidi, S., Hankey, G. J., Hannan, M., Haque, S., Harandi, H., Harlianto, N., Hasan, S., Hasan, S., Hasani, H., Hassanipour, S., Hassen, M., Haubold, J., Hayat, K., Heidari, G., Heidari, M., Hessami, K., Hiraike, Y., Holla, R., Hossain, S., Hossain, M., Hosseini, M., Hosseinzadeh, M., Hosseinzadeh, H., Huang, J., Huda, N., Hussain, S., Huynh, H., Hwang, B., Ibitoye, S., Ikeda, N., Ilic, I. M., Ilic, M., Inbaraj, L., Iqbal, A., Islam, S., Islam, R. M., Ismail, N., Iso, H., Isola, G., Itumalla, R., Iwagami, M., Iwu, C. D., Iyamu, I., Iyasu, A. 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I., Vos, T., GBD 2021 Diabet Collaborators 2023; 402 (10397): 203-234

    Abstract

    Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050.Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively.In 2021, there were 529 million (95% uncertainty interval [UI] 500-564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8-6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7-9·9]) and, at the regional level, in Oceania (12·3% [11·5-13·0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1-79·5) in individuals aged 75-79 years. Total diabetes prevalence-especially among older adults-primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1-96·8) of diabetes cases and 95·4% (94·9-95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5-71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5-30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22-1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1-17·6) in north Africa and the Middle East and 11·3% (10·8-11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%.Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers.Bill & Melinda Gates Foundation.

    View details for DOI 10.1016/S0140-6736(23)01301-6

    View details for Web of Science ID 001084390700001

    View details for PubMedID 37356446

    View details for PubMedCentralID PMC10364581

  • ENDOSCOPIC SUBMUCOSAL DISSECTION OF ESOPHAGEAL ADENOCARCINOMA DEEMED PATHOLOGICALLY CURATIVE RESULTS IN FEW RECURRENCES AT LONG-TERM SURVEILLANCE: A NORTH AMERICAN STUDY Schenck, R., Bhatt, A., Ngamruengphong, S., Friedland, S., Aihara, H., Dewitt, J., Patrie, J., Foster, S., Joseph, A., Arayakarnkul, S., Mercado, M., Northern, N., Aadam, A., Othman, M., Sethi, A., Sharaiha, R., Nishimura, M., Fukami, N., Hwang, J., Yang, D., Draganov, P., Wang, A. MOSBY-ELSEVIER. 2023: AB1105-AB1106

    View details for Web of Science ID 001038022802459

  • OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR PREVIOUSLY ATTEMPTED COLORECTAL LESIONS: AN INTERNATIONAL MULTICENTER EXPERIENCE Arayakarnkul, S., Aihara, H., Repici, A., Da Rio, L., Maselli, R., Capogreco, A., Kawaguti, F., Maluf-Filho, F., Friedland, S., Bechara, R., Mohapatra, S., Fukami, N., Joseph, A., Bhatt, A., Schlachterman, A., Kumar, A., Wang, A., Buerlein, R., Song, L., Deepali, F., Hasan, M., Yang, D., Kumta, N., Diehl, D., Rimondi, A., Lucaciu, L., Despott, E., Sharaiha, R., Mahadev, S., Hassan, K., Abu-Hammour, M., Kumbhari, V., Park, J., Robles-Medranda, C., Arevalo-Mora, M., Alcivar-Vasquez, J., Jawaid, S., Khalaf, M., Al Ghamdi, S., Othman, M., Ngamruengphong, S. MOSBY-ELSEVIER. 2023: AB430-AB431

    View details for Web of Science ID 001038022801059

  • ENDOSCOPIC SUBMUCOSAL DISSECTION OF ESOPHAGEAL ADENOCARCINOMA DEEMED PATHOLOGICALLY CURATIVE RESULTS IN FEW RECURRENCES AT LONG-TERM SURVEILLANCE: A NORTH AMERICAN STUDY Schenck, R., Bhatt, A., Ngamruengphong, S., Friedland, S., Aihara, H., Dewitt, J., Patrie, J., Foster, S., Joseph, A., Arayakarnkul, S., Mercado, M., Northern, N., Aadam, A., Othman, M., Sethi, A., Sharaiha, R., Nishimura, M., Fukami, N., Hwang, J., Yang, D., Draganov, P., Wang, A. MOSBY-ELSEVIER. 2023: AB1018-AB1019

    View details for Web of Science ID 001038022802336

  • Initial Multicenter Experience of Traction Wire Endoscopic Submucosal Dissection TECHNIQUES AND INNOVATIONS IN GASTROINTESTINAL ENDOSCOPY Joseph, A., Kahaleh, M., Li, A. A., Haber, G. B., Kedia, P., Makiguchi, M., Sharma, N. R., Ha Hwang, J., Chak, A., Al-Taee, A. M., Braun, D., Mok, S., Mehta, N. A., Gorgun, E., Vargo, J., Abe, S., Saito, Y., Stevens, T., Bhatt, A. 2023; 25 (1): 21-29

    View details for DOI 10.1016/j.tige.2022.10.002

    View details for Web of Science ID 001035713900001