Institute Affiliations

Professional Education

  • Doctor of Public Health, University of Alabama at Birmingham (2014)

Contact

  • Academic
    ahyuda@stanford.edu
    University - Staff Department: Pediatric Neurology Position: Population Health Science Research Data Professional

Additional Info

  • Mail Code: 5327

All Publications

  • Independent role of neonatal seizures in subsequent neurological outcomes: a population-based study DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY Oh, A., Thurman, D. J., Kim, H. 2019; 61 (6): 661-+

    View details for DOI 10.1111/dmcn.14174

    View details for Web of Science ID 000466814700016

  • Independent role of neonatal seizures in subsequent neurological outcomes: a population-based study. Developmental medicine and child neurology Oh, A., Thurman, D. J., Kim, H. 2019

    Abstract

    AIM: This population-based study aimed to estimate the impact of neonatal seizures on subsequent neurological outcomes, regardless of underlying etiology.METHOD: We performed a retrospective cohort study (1st January 2009-31st December 2014), using a USA nationwide claims database. Newborn infants enrolled in 2009 were followed for up to 6years. Neonatal seizures were identified by combining the International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code of 779.0 (convulsions in newborn), procedure codes of electroencephalogram and brain imaging, and antiepileptic drugs claims. Cox regression models were built to estimate the independent impact of neonatal seizures on developing epilepsy, intellectual disability, psychiatric/behavioral disorders, and headache.RESULTS: Out of 490071 newborn infants (251850 males [51.4%], 238221 females [48.6%]), 800 neonatal seizure cases were identified. After controlling for sex, birthweight, preterm birth status, and underlying etiology, neonates with seizures were more likely to have epilepsy (hazard ratio=32.7; 95% confidence interval [CI]=27.7-38.7; p<0.001), intellectual disability (hazard ratio=2.0; 95% CI=1.8-2.3; p<0.001), and headache (hazard ratio=1.6; 95% CI=1.1-2.2; p=0.013) than those without seizures.INTERPRETATION: Observed covariates being equal, seizures in neonates appeared to play a significant role in developing epilepsy, intellectual disability, and headache. The findings showed a detrimental impact of the event in the very early life on neurological outcomes in later life.WHAT THIS PAPER ADDS: Seizures had their own impact on the development of adverse neurological outcomes. The magnitude of impact was quite large in epilepsy.

    View details for PubMedID 30714130