Amir Norouzpour

All Publications

• <i>Fcirc</i> statistic for steady-state evoked potentials; a generalized version of<i> T2circ</i> statistic BIOMEDICAL SIGNAL PROCESSING AND CONTROL Norouzpour, A., Roberts, T. L. 2024; 87

  View details for DOI 10.1016/j.bspc.2023.105549

  View details for Web of Science ID 001092748300001

• A complementary note for the analytical method to estimate individual attention fluctuation using steady-state evoked potentials Biomedical Signal Processing and Control Norouzpour, A., Roberts, T. L., Klein, S. A. 2023

  View details for DOI 10.1016/j.bspc.2022.104406

• Long-term Visual and Refractive Outcomes of Argon Laser-treated Retinopathy of Prematurity. Journal of ophthalmic & vision research Farvardin, M., Kalantari, Z., Talebnejad, M., Alamolhoda, M., Norouzpour, A. 2022; 17 (3): 384-389

  Abstract

  In this case-control study, we measured visual acuity, objective refraction, ocular biometric parameters, and strabismus in premature cases classified according to the following categories: argon laser-treated retinopathy of prematurity (ROP), untreated spontaneously regressed ROP, no ROP, and full-term controls.Cases with a history of prematurity at six years of age were categorized into the following groups: patients with a history of treated type 1 ROP using argon laser (group I), untreated spontaneously regressed ROP (group II), and no history of ROP (group III). Group IV included age-matched healthy full-term controls. Funduscopy was performed for all the cases and the control group.In total, 24 eyes of 12 laser-treated ROP cases, 186 eyes of 93 spontaneously regressed ROP patients, 74 eyes of 37 premature cases with no history of ROP, and 286 eyes of 143 controls were included in the study. The mean spherical equivalent in the treated cases was not significantly different from that in the untreated cases and patients in group III. However, the average cylindrical power was significantly different among the groups (P < 0.004). Furthermore, anisometropia ( ≥ 1.5 diopters) was diagnosed with a higher rate in the treated cases (P = 0.03). The corneal curvature of the laser-treated eyes was significantly steeper and the axial length was significantly shorter than those in the other groups (P < 0.002 and P < 0.001, respectively, for multivariate analysis). Strabismus was found in three treated patients (25%). Additionally, there were three treated eyes (12.5%) diagnosed with macular dragging.Premature cases including those who had a history of argon laser-treated ROP and those with untreated spontaneously regressed ROP showed acceptable long-term visual and refractive outcomes along with a fairly low rate of ocular disorders.

  View details for DOI 10.18502/jovr.v17i3.11576

  View details for PubMedID 36160100

  View details for PubMedCentralID PMC9493422

• A novel analytical method to measure intra-individual variability of steady-state evoked potentials; new insights into attention deficit BIOMEDICAL SIGNAL PROCESSING AND CONTROL Norouzpour, A., Klein, S. A. 2022; 71

  View details for DOI 10.1016/j.bspc.2021.103109

  View details for Web of Science ID 000713282900005

• Central corneal thickness measurements in phakic, pseudophakic, and aphakic children with ultrasound pachymetry and different non-contact devices INTERNATIONAL OPHTHALMOLOGY Farvardin, M., Shamsi, A., Norouzpour, A., Jalalpour, M. 2022; 42 (1): 65-72

  Abstract

  Evidence for choosing a satisfactory device for central corneal thickness (CCT) measurement in children particularly pseudophakic and aphakic ones is insufficient. The aim of this study is to compare four differently measured CCTs obtained using ultrasound pachymetry (UP), Pentacam, partial coherence interferometry (PCI), and specular microscopy (SM) in phakic, pseudophakic, and aphakic children and assess the agreement between the six pairs of the methods.Children with history of cataract surgery at age six or younger and phakic children were recruited into this study. CCT was measured using UP (Optikon 2000, Rome, Italy), Pentacam (Oculus Inc, Wetzlar, Germany), PCI (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany), and SM (Topcon SP-3000P; Topcon Corporation, Japan).One-hundred two eyes (53 phakic, 29 pseudophakic, and 20 aphakic eyes) were included. The mean ages (± SD) of phakic, pseudophakic, and aphakic cases were 9.75 (± 3.3), 9.9 (± 2.3), and 8.2 (± 2.8) years, respectively. The mean CCTs (± SE) for phakic children using Pentacam, PCI, UP, and SM were 549.7 (± 5.0), 546.5 (± 4.5), 565.9 (± 5.5), and 506.2 (± 4.4) μm, respectively, for pseudophakic cases were 570.1 (± 6.4), 565.0 (± 6.1), 571.9 (± 6.3), and 524.3 (± 6.3) μm, respectively, and for aphakic participants were 635.3 (± 14.2), 635.4 (± 14.5), 649.0 (± 13.5), and 589.1 (± 13.3) μm, respectively.Compared to Pentacam and PCI, SM underestimated CCT particularly in phakic and pseudophakic children, whereas UP slightly overestimated CCT especially in phakic and aphakic children. Furthermore, Pentacam and PCI had the closest agreement. By contrast, SM had the poorest agreement with the other three methods.

  View details for DOI 10.1007/s10792-021-02000-y

  View details for Web of Science ID 000683304000004

  View details for PubMedID 34370171

• Light exposure in acute central serous chorioretinopathy EYE Norouzpour, A. 2022; 36 (1): 243

  View details for DOI 10.1038/s41433-020-01388-8

  View details for Web of Science ID 000606372900001

  View details for PubMedID 33423042

  View details for PubMedCentralID PMC8727572

• Glaucomatous Optic Neuropathy: Associated With Cognitive Impairment? JOURNAL OF GLAUCOMA Norouzpour, A. 2021; 30 (1): E21

  View details for DOI 10.1097/IJG.0000000000001668

  View details for Web of Science ID 000610964500010

  View details for PubMedID 32925519

• Birjand longitudinal aging study (BLAS): the objectives, study protocol and design (wave I: baseline data gathering) JOURNAL OF DIABETES AND METABOLIC DISORDERS Moodi, M., Firoozabadi, M., Kazemi, T., Payab, M., Ghaemi, K., Miri, M., Sharifzadeh, G., Fakhrzadeh, H., Ebrahimpur, M., Arzaghi, S., Zarban, A., Mirimoghadam, E., Sharifi, A., Hosseini, M., Esmaeili, A., Mohammadifard, M., Ehsanbakhsh, A., Ahmadi, Z., Yaghoobi, G., Hosseinirad, S., Davari, M., Heydari, B., Nikandish, M., Norouzpour, A., Naseri, S., Khorashadizadeh, M., Mohtashami, S., Mehdizadeh, K., Ahmadi, G., Soltani, H., Khodbakhshi, H., Sharifi, F., Larijan, B. 2020; 19 (1): 551-559

  Abstract

  The pace of population aging is growing rapidly around the world. Aging is associated with the emergence of different health status including geriatric syndrome such as frailty, diabetes, cardiovascular diseases, and dementia. These conditions are the most prominent challenges for health care systems and also elderly people. Therefore, understanding these changes can help scientists to prevent and treat significant health issues and also improve the functional ability of older adults.This is a protocol of the first wave of Birjand Longitudinal Aging Study that is an ongoing community-based prospective cohort study with a following up at least 10 years. This study carries out on aged population ≥ 60 years which were residents in Birjand County (urban and rural older subjects). The selection of the participants of this study in urban areas is based on an age group weighted multistage stratified random sample while in the rural region the sample was selected from all ten rural regions of Birjand County by simple random sampling. The rural region sampling was based on the list of the aged population which were under the coverage of the rural health center. Sociodemographic, past medical history, lifestyle, sleep, activities of daily living, cognitive function, quality of life, and social capital were evaluated by interviewing with the participants and one of the informants. Anthropometric measures, electrocardiography, and interpretation of ophthalmologic examination were carried out by experts. Fasting Blood samples were collected and bio-banked in - 80 °C. then finally biochemical and hematologic markers were measured.This is the protocol of stage one baseline of Birjand Longitudinal Aging Study (BLAS). The BLAS is an enjoining study, the first phase of its baseline was carried out on a community- dwelling aged population sample ≥ 60 years who were residents in urban and rural regions of Birjand County. This is a community based prospective cohort study with at least 10 years follow up of participants. The data for 65% of older subjects (response rate = 65%) that lived in clusters were collected.This study can help scientists to recognize some risk factors related to the aging process and also aware policymakers about the necessity to create heath care services at regional and even national levels.

  View details for DOI 10.1007/s40200-020-00504-5

  View details for Web of Science ID 000571450700062

  View details for PubMedID 32550207

  View details for PubMedCentralID PMC7271344

• Coronavirus disease 2019: Global Contamination and Global Cleanup GALEN MEDICAL JOURNAL Norouzpour, A., Nejabat, M., Mehdizadeh, A. 2020; 9: e1921

  View details for DOI 10.31661/gmj.v9i0.1921

  View details for Web of Science ID 000569900400001

  View details for PubMedID 34466613

  View details for PubMedCentralID PMC8344154

• Tuberculosis: A Cunning Disease Presenting with Endopericarditis-Associated Bilateral Uveitis TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY Yaghoubi, G., Abedi, F., Ziaee, M., Norouzpour, A. 2019; 49 (6): 361-363

  Abstract

  Mycobacterium tuberculosis can spread through the entire body but rarely involves the eye. We report a patient with endophthalmitis in one eye and simultaneous retinal vasculitis in the fellow eye. Systemic work-up suggested infective endopericarditis. Polymerase chain reaction analyses of the vitreous and pericardial fluid were positive for M. tuberculosis. We initiated a four-drug antituberculous treatment regimen (isoniazid, ethambutol, pyrazinamide, and rifampin). After two weeks, we discontinued all the medications due to drug-induced hepatitis. We restarted isoniazid and rifampin, but hepatitis recurred. Finally, we chose isoniazid/ethambutol combination for 18 months, and also administered short-term systemic corticosteroid. His vision improved considerably with no recurrence of hepatitis or tuberculosis for 3 years after completion of treatment. Ocular tuberculosis can masquerade as other causes of intraocular inflammation, and a medical team consisting of an ophthalmologist and an infectious disease specialist might be needed for the diagnosis and management.

  View details for DOI 10.4274/tjo.galenos.2019.55889

  View details for Web of Science ID 000505067800010

  View details for PubMedID 31893593

  View details for PubMedCentralID PMC6961073

• Hydrophilic Acrylic Intraocular Lens Opacification after Descemet Stripping Automated Endothelial Keratoplasty. Journal of ophthalmic & vision research Norouzpour, A., Zarei-Ghanavati, S. 2016; 11 (2): 225-7

  Abstract

  To report hydrophilic acylic intraocular lens (IOL) opacification after Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) in an eye with multiple prior intraocular surgeries and iatrogenic aniridia.A 34-year-old woman with history of penetrating keratoplasty (PKP) for advanced keratoconus and subsequent Urrets-Zavalia Syndrome (UZS) underwent phacoemulsification and hydrophilic acrylic IOL implantation for her cataract. In order to control post-PKP glaucoma, multiple glaucoma surgeries including two glaucoma drainage implants were performed. As the original corneal graft failed, the patient subsequently underwent re-PKP. Four years later, she underwent DSAEK for treatment of the second graft failure. Ten months after DSAEK, a double semi-circular pattern of IOL opacification was observed on the anterior surface of the IOL. The patient did not report any complaints and we decided not to exchange the IOL.In an eye with UZS and iatrogenic aniridia, IOL opacification may result from direct contact between the IOL surface and exogenous air. Aniridia can be a risk factor for development of IOL opacification after DSAEK. Further studies are required to confirm this hypothesis.

  View details for DOI 10.4103/2008-322X.158897

  View details for PubMedID 27413506

  View details for PubMedCentralID PMC4926573

• Central serous chorioretinopathy: from glucocorticoids to light intensity INTERNATIONAL JOURNAL OF OPHTHALMOLOGY Norouzpour, A., Abrishami, M. 2016; 9 (2): 312-314

  Abstract

  Central serous chorioretinopathy (CSC) is characterized by a localized accumulation of subretinal fluid and an idiopathic focal leakage from choroidal vessels. The exact pathogenesis of CSC, however, still remains obscure. In this paper, we hypothesized that CSC may result from a response of choroidal vessels to an acute increase in the environmental light intensity leading to a focal leakage from the choroidal vessels. High levels of glucocorticoids, in our proposed model, may cause persistence rather than initiation of the focal leakage, probably by suppressing the synthesis of collagen and extracellular matrix components and inhibiting fibroblastic activity.

  View details for Web of Science ID 000369551700025

  View details for PubMedID 26949657

  View details for PubMedCentralID PMC4761749

• Treatment of Chronic Central Serous Chorioretinopathy with Oral Methotrexate JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS Abrishami, M., Mousavi, M., Hosseini, S., Norouzpour, A. 2015; 31 (8): 468-475

  Abstract

  To evaluate the effects of oral methotrexate (MTX) in patients with chronic central serous chorioretinopathy (CSC).This is an interventional, prospective uncontrolled clinical trial, which included 23 eyes of 23 consecutive patients presenting with chronic symptomatic CSC and persistent subretinal fluid (SRF) for longer than 3 months. All patients were treated with 7.5 mg/week of oral MTX for 12 weeks. The best corrected visual acuity (BCVA), central macular thickness (CMT), SRF, and total macular volume recorded by monthly optical coherence tomography were analyzed. Complete blood count and serum liver enzymes level were monitored.Mean duration of CSC was 13 months (3-36 months). Mean BCVA improved from 20/40 at baseline to 20/30 at the third month and 20/28 at the sixth month (P=0.002 and 0.003, respectively). Mean CMT decreased from 375 μm at baseline to 278 μm and 265 μm at the third and sixth month (P=0.002 and 0.007, respectively). Mean total macular volume decreased from 9.33 mm(3) at baseline to 8.48 and 8.31 mm(3) at the third and sixth month (P=0.001 and 0.001, respectively). Thirteen (62%) eyes achieved complete resolution of SRF. No MTX-associated toxicity was detected.Low-dose oral MTX may be an alternative therapeutic option for the treatment of chronic CSC. This study paves the way for a randomized clinical trial comparing the effects of MTX treatment with photodynamic therapy or observation.

  View details for DOI 10.1089/jop.2014.0173

  View details for Web of Science ID 000362270600005

  View details for PubMedID 26172430

• Retinal vascular fractals in Behcet's Disease: A screening method? SAUDI JOURNAL OF OPHTHALMOLOGY Norouzpour, A., Mehdizadeh, A. 2015; 29 (3): 210-211

  Abstract

  The branching pattern of retinal vessels may be affected in Behçet's Disease (BD). Fractal analysis can be used as a new method to quantify the changes of the vascular branching pattern. In this study, we examined, for the first time, the relationship between retinal fractal dimension (D f) and retinal vascular changes seen in patients with BD.We conducted a retrospective study of 10 new cases of BD with clinically ocular involvement. Color fundus images taken from both eyes of the participants have been analyzed, and D f of the whole retinal vasculature was quantified using a novel computer-based program. The resultant D f was compared with that of healthy individuals.The mean D f, calculated from 20 fundus images of cases with BD, was 1.59 ± 0.064. It was lower than that of healthy participants (1.65 ± 0.060) significantly (P = 0.013).Retinal fractal analysis of cases with BD has been performed for the first time, and the results showed that early retinal vascular changes seen in new cases of BD are associated with lower retinal D f. Retinal fractal analysis in BD can be practically utilized as a potential tool for screening of retinal involvement, evaluating the prognosis and the response to treatment.

  View details for DOI 10.1016/j.sjopt.2015.01.003

  View details for Web of Science ID 000217146200008

  View details for PubMedID 26155081

  View details for PubMedCentralID PMC4487937

• Central serous chorioretinopathy and bright light ACTA OPHTHALMOLOGICA Norouzpour, A. 2014; 92 (8): e688-e689

  View details for DOI 10.1111/aos.12484

  View details for Web of Science ID 000345342600017

  View details for PubMedID 25042604

• New insights into blindness; mechanical fatigue of optic nerve head in glaucomatous optic neuropathy. Journal of medical engineering & technology Norouzpour, A., Mehdizadeh, A. 2014; 38 (7): 367-71

  Abstract

  A common cause of blindness worldwide is glaucoma. It is characterized by visual field loss which is caused by optic nerve damage leading to glaucomatous optic neuropathy (GON). Modelling of GON development may be helpful for designing strategies to decelerate the rate of GON progression and prevent GON development at early stages. Attempts to complete the modelling of GON development continue. In this paper, it was speculated that the modelling could be more completed through a biomechanical point of view. GON may result from the mechanical fatigue effects of radial tensile stress (TS), caused by intra-ocular pressure (IOP), on the optic nerve head (ONH). The mechanical fatigue rate is influenced by patient's age, the maximum and minimum magnitude of IOP, the amplitude of IOP and TS fluctuations, the ONH geometry, scleral thickness and biomechanical properties of the sclera, particularly the peripapillary part, and the axial length of the globe. Based on this model, more efficient strategies can be developed to augment the ONH and decelerate the progression of glaucomatous optic nerve damage, and even screen high-risk individuals at early stages.

  View details for DOI 10.3109/03091902.2014.950435

  View details for PubMedID 25188359

• Letter to the Editor: Bright Light Induces Choroidal Thickening in Chickens OPTOMETRY AND VISION SCIENCE Norouzpour, A., Mehdizadeh, A. 2014; 91 (4): E94

  View details for DOI 10.1097/OPX.0000000000000207

  View details for Web of Science ID 000333756600001

  View details for PubMedID 24561963

• Prehospital Management of Gunshot Patients at Major Trauma Care Centers: Exploring the Gaps in Patient Care TRAUMA MONTHLY Norouzpour, A., Khoshdel, A., Modaghegh, M., Kazemzadeh, G. 2013; 18 (2): 62-66

  Abstract

  Prehospital management of gunshot-wounded (GW) patients influences injury-induced morbidity and mortality.To evaluate prehospital management to GW patients emphasizing the protocol of patient transfer to appropriate centers.This prospective study, included all GW patients referred to four major, level-I hospitals in Mashhad, Iran. We evaluated demographic data, triage, transport vehicles of patients, hospitalization time and the outcome.There were 66 GW patients. The most affected body parts were extremities (60.6%, n = 40); 59% of cases (n = 39) were transferred to the hospitals with vehicles other than an ambulance. Furthermore, 77.3% of patients came to the hospitals directly from the site of event, and 22.7% of patients were referred from other medical centers. EMS action intervals from dispatchers to scene departure was not significantly different from established standards; however, arrival to hospital took longer than optimal standards. Additionally, time spent at emergency wards to stabilize vital signs was significantly less in patients who were transported by EMS ambulances (P = 0.01), but not with private ambulances (P = 0.47). However, ambulance pre-hospital care was not associated with a shorter hospital stay. Injury Severity was the only determinant of hospital stay duration (β = 0.36, P = 0.01) in multivariate analysis.GW was more frequent in extremities and the most patients were directly transferred from the accident site. EMS (but not private) ambulance transport improved patients' emergency care and standard time intervals were achieved by EMS; however more than a half of the cases were transferred by vehicles other than an ambulance. Nevertheless, ambulance transportation (either by EMS or by private ambulance) was not associated with a shorter hospital stay. This showed that upgrade of ambulance equipment and training of private ambulance personnel may be needed.

  View details for DOI 10.5812/traumamon.10438

  View details for Web of Science ID 000218902400006

  View details for PubMedID 24350154

  View details for PubMedCentralID PMC3860682

• Autoregulation of blood flow: Vessel diameter changes in response to different temperatures. Journal of biomedical physics & engineering Norouzpour, A., Hooshyar, Z., Mehdizadeh, A. 2013; 3 (2): 63-6

  Abstract

  Autoregulation of blood flow is a marvelous phenomenon balancing blood supply and tissue demand. Although many chemically-based explanations for this phenomenon have been proposed and some of them are commonly used today, biomechanical aspects of this phenomenon was neglected. The biomechanical aspect provides insights to us to model vessel diameter changes more precisely and comprehensively. One important aspect of autoregulation phenomenon is temperature changes of the tissue resulted from tissue metabolism. We hypothesize that temperature changes can affect the mechanical properties of the vessel wall leading to vessel diameter changes during autoregulation. Mechanical modeling of vessel diameter changes can also be useful to explain other phenomena in which the vessel diameter changes in response to temperature alterations. Through the mechanical modeling of any vessel, the analysis of temperature-induced changes in vessel diameter can be done more precisely.

  View details for PubMedID 25505749

  View details for PubMedCentralID PMC4204495

• A novel insight into keratoconus: mechanical fatigue of the cornea. Medical hypothesis, discovery & innovation ophthalmology journal Norouzpour, A., Mehdizadeh, A. 2012; 1 (1): 14-7

  Abstract

  An integrated model for keratectasia risk assessment has received much attention over many years. The objective of this article is to propose a more complete, conceptual model by which high risk individuals can be screened, even with no topographic irregularity or corneal thinning. In this model, corneal ectasia results from the fatigue effect of cyclic shear stress and tensile stress, caused by eye rubbing and fluctuating intraocular pressure (IOP), respectively, on corneal microstructures. The model clarifies the importance of the magnitude of shearing force applied by eye rubbing, the amplitude of IOP fluctuations, the frequency of eye rubbing and IOP fluctuations, the geometry of the cornea, the temperature of the cornea, and the effects of oxidative stress on the cornea in keratectasia development. Therefore, preoperative screening strategies based on these concepts can be designed to assess the risk of keratectasia at an early stage, and select the best candidates who can benefit from keratorefractive surgeries.

  View details for PubMedID 24600612

  View details for PubMedCentralID PMC3939737

• Designing strategies to control coronary atherosclerosis using a new model INTERNATIONAL JOURNAL OF CARDIOLOGY Mehdizadeh, A., Norouzpour, A. 2010; 143 (3): 440-441

  View details for DOI 10.1016/j.ijcard.2008.12.004

  View details for Web of Science ID 000281874500038

  View details for PubMedID 19117627

• New insights in atherosclerosis: Endothelial shear stress as promoter rather than initiator MEDICAL HYPOTHESES Mehdizadeh, A., Norouzpour, A. 2009; 73 (6): 989-993

  Abstract

  The etiology of focal distribution of atherosclerotic lesions has received much attention for many years. Current theories focus on mechanical factors such as low endothelial shear stress as an initiating factor for atherosclerosis formation. However, some evidences revealed that it could not be initiator of endothelial damage. We hypothesize that endothelial damage results from the fatigue effect of pulse pressure on endothelial layer. In our model, heart rate, magnitude of pulse pressure, geometry and chemical environment of endothelial layer determine the rate of endothelial damage accumulation, and low endothelial shear stress acts as promoter of atherosclerosis rather than initiator. If this model is correct, it can provide a framework for speculating about the risk of endothelial stress rupture in the population as a whole and in patients undergone arterial grafting procedures, and how this might be reduced.

  View details for DOI 10.1016/j.mehy.2008.11.049

  View details for Web of Science ID 000272923000030

  View details for PubMedID 19577380