Ananya Goyal

All Publications

• PET-MRI: the promise of multi-tissue imaging of early disease mechanisms in osteoarthritis. Osteoarthritis and cartilage Kogan, F., Watkins, L. E., Goyal, A. 2024

  View details for DOI 10.1016/j.joca.2024.10.011

  View details for PubMedID 39489372

• CLUSTERING ANALYSIS OF [18F]SODIUM FLUORIDE PET-MRI ACUTE METABOLIC BONE RESPONSE TO STAIR CLIMBING IN KNEE, FEMORAL NECK AND LUMBAR SPINE Barbieri, M., Goyal, A., Gatti, A. A., Pedersen, R., Haddock, B., Kogan, F. ELSEVIER SCI LTD. 2024: S360

  View details for Web of Science ID 001280544200513

• Multimodal positron emission tomography (PET) imaging in non-oncologic musculoskeletal radiology. Skeletal radiology Kogan, F., Yoon, D., Teeter, M. G., Chaudhari, A. J., Hales, L., Barbieri, M., Gold, G. E., Vainberg, Y., Goyal, A., Watkins, L. 2024

  Abstract

  Musculoskeletal (MSK) disorders are associated with large impacts on patient's pain and quality of life. Conventional morphological imaging of tissue structure is limited in its ability to detect pain generators, early MSK disease, and rapidly assess treatment efficacy. Positron emission tomography (PET), which offers unique capabilities to evaluate molecular and metabolic processes, can provide novel information about early pathophysiologic changes that occur before structural or even microstructural changes can be detected. This sensitivity not only makes it a powerful tool for detection and characterization of disease, but also a tool able to rapidly assess the efficacy of therapies. These benefits have garnered more attention to PET imaging of MSK disorders in recent years. In this narrative review, we discuss several applications of multimodal PET imaging in non-oncologic MSK diseases including arthritis, osteoporosis, and sources of pain and inflammation. We also describe technical considerations and recent advancements in technology and radiotracers as well as areas of emerging interest for future applications of multimodal PET imaging of MSK conditions. Overall, we present evidence that the incorporation of PET through multimodal imaging offers an exciting addition to the field of MSK radiology and will likely prove valuable in the transition to an era of precision medicine.

  View details for DOI 10.1007/s00256-024-04640-4

  View details for PubMedID 38492029

  View details for PubMedCentralID 6899769

• Imaging of joint response to exercise with MRI and PET. Skeletal radiology Watkins, L. E., Goyal, A., Gatti, A. A., Kogan, F. 2023

  Abstract

  Imaging of the joint in response to loading stress may provide additional measures of joint structure and function beyond conventional, static imaging studies. Exercise such as running, stair climbing, and squatting allows evaluation of the joint response to larger loading forces than during weight bearing. Quantitative MRI (qMRI) may assess properties of cartilage and meniscus hydration and organization in vivo that have been investigated to assess the functional response of these tissues to physiological stress. [18F]sodium fluoride ([18F]NaF) interrogates areas of newly mineralizing bone and provides an opportunity to study bone physiology, including perfusion and mineralization rate, as a measure of joint loading stress. In this review article, methods utilizing quantitative MRI, PET, and hybrid PET-MRI systems for assessment of the joint response to loading from exercise in vivo are examined. Both methodology and results of various studies performed are outlined and discussed. Lastly, the technical considerations, challenges, and future opportunities for these approaches are addressed.

  View details for DOI 10.1007/s00256-022-04271-7

  View details for PubMedID 36646851

• Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee. Frontiers in nuclear medicine (Lausanne, Switzerland) Watkins, L. E., Haddock, B., Goyal, A., Kogan, F. 2023; 3: 1194961

  Abstract

  Introduction: Accurately estimating bone perfusion and metabolism using [18F]NaF kinetics from shorter scan times could help address concerns related to patient comfort, motion, and throughput for PET scans. We examined the impact of changing the PET scan duration on the accuracy of [18F]NaF kinetic parameters in the knee.Methods: Both knees of twenty participants with and without osteoarthritis were scanned using a hybrid PET-MRI system (53±13 years, BMI 25.9±4.2 kg/m2, 13 female). Seventeen participants were scanned for 54±2 min, and an additional three participants were scanned for 75 min. Patlak K i and Hawkins kinetic parameters (K i, K 1, extraction fraction) were assessed using 50- or 75-minutes of scan data as well as for scan durations that were retrospectively shortened. The error of the kinetic uptake parameters was calculated in bone regions throughout the knee.Results: The mean error of Patlak K i, Hawkins K i, K 1, and extraction fraction was less than 10% for scan durations exceeding 30 min and decreased with increasing scan duration.Conclusions: The length of dynamic data acquisition can be reduced to as short as 30 min while retaining accuracy within the limits of reproducibility of Hawkins kinetic uptake parameters.

  View details for DOI 10.3389/fnume.2023.1194961

  View details for PubMedID 39355034