Education & Certifications

  • MS, University of California - San Diego, Bioengineering (2021)
  • BS, University of California - Los Angeles, Bioengineering (2019)

Contact

  • Academic
    aperley@stanford.edu
    University - Student Department: Bioengineering Position: Graduate

Additional Info

  • Mail Code: 4245

All Publications

  • Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography. Bioelectronic medicine Perley, A., Roustaei, M., Aguilar-Rivera, M., Kunkel, D. C., Hsiai, T. K., Coleman, T. P., Abiri, P. 2021; 7 (1): 12

    Abstract

    BACKGROUND: Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which electrical stimulation affects physiology.METHODS: A leadless inductively-powered pacemaker was implanted on the gastric serosa in an anesthetized pig. Wireless pacing was performed at transmitter-to-receiver distances up to 20mm, frequency of 0.05Hz, and pulse width of 400ms. Electrogastrogram (EGG) recordings using cutaneous and serosal electrode arrays were analyzed to compute spectral and spatial statistical parameters associated with the slow wave.RESULTS: Our data demonstrated evident change in EGG signal patterns upon initiation of pacing. A buffer period was noted before a pattern of entrainment appeared with consistent and low variability in slow wave direction. A spectral power increase in the EGG frequency band during entrainment also suggested that pacing increased strength of the slow wave.CONCLUSION: Our preliminary in vivo study using wireless pacing and concurrent EGG recording established the foundations for a minimally invasive approach to understand and optimize the effect of pacing on gastric motor activity as a means to treat conditions of gastric dysmotility.

    View details for DOI 10.1186/s42234-021-00074-8

    View details for PubMedID 34425917