Andrew Perley

All Publications

• A Mutual Information Measure of Phase-Amplitude Coupling using High Dimensional Sparse Models. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Perley, A., Coleman, T. P. 2022; 2022: 21-24

  Abstract

  Cross frequency coupling (CFC) between electrophysiological signals in the brain has been observed and it's abnormalities have been observed in conditions such as Parkinson's disease and epilepsy. More recently, CFC has been observed in stomach-brain electrophysiologic studies and thus becomes an enticing possible target for diseases involving aberrations of the gut-brain axis. However, current methods of detecting coupling do not attempt to capture the underlying statistical relationships that give rise to this coupling. In this paper, we demonstrate a new method of calculating phase amplitude coupling by estimating the mutual information between phase and amplitude, using a flexible parametric modeling approach. Specifically, we develop an exponential generalized linear model (GLM) to model amplitude given phase, using a high dimensional basis of von-Mises function regressors and l1 regularized model selection. Using synthetically generated gut-brain coupled signals, we demonstrate that our method outperforms the existing gold-standard methods for detectable low-levels of phase amplitude coupling through receiver operating characteristic (ROC) curve analysis.

  View details for DOI 10.1109/EMBC48229.2022.9871816

  View details for PubMedID 36086427

• Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography. Bioelectronic medicine Perley, A., Roustaei, M., Aguilar-Rivera, M., Kunkel, D. C., Hsiai, T. K., Coleman, T. P., Abiri, P. 2021; 7 (1): 12

  Abstract

  BACKGROUND: Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical complications and an incomplete understanding of the mechanism by which electrical stimulation affects physiology.METHODS: A leadless inductively-powered pacemaker was implanted on the gastric serosa in an anesthetized pig. Wireless pacing was performed at transmitter-to-receiver distances up to 20mm, frequency of 0.05Hz, and pulse width of 400ms. Electrogastrogram (EGG) recordings using cutaneous and serosal electrode arrays were analyzed to compute spectral and spatial statistical parameters associated with the slow wave.RESULTS: Our data demonstrated evident change in EGG signal patterns upon initiation of pacing. A buffer period was noted before a pattern of entrainment appeared with consistent and low variability in slow wave direction. A spectral power increase in the EGG frequency band during entrainment also suggested that pacing increased strength of the slow wave.CONCLUSION: Our preliminary in vivo study using wireless pacing and concurrent EGG recording established the foundations for a minimally invasive approach to understand and optimize the effect of pacing on gastric motor activity as a means to treat conditions of gastric dysmotility.

  View details for DOI 10.1186/s42234-021-00074-8

  View details for PubMedID 34425917